Abstract
Objectives: Coronavirus disease 2019 (COVID-19) is an ongoing major health emergency, but its occurrence and clinical impact on patients withliver cirrhosis is unknown. Therefore, we conducted a population-based study of 2.6 million Danish citizens investigating the occurrence and impact of COVID-19 in patients with liver cirrhosis. Materials and methods: A prospective population-based cohort study was conducted in the Capital Region of Denmark and Region Zealand in the study period between 1 March 2020 up until 31 May 2020, with the only eligibility criteria being a reverse-transcriptase polymerase chain reaction for presence of viral genomic material confirming COVID-19. The patients were subsequently stratified according to presence of pre-existing liver cirrhosis. Results: Among 575,935 individuals tested, 1713 patients had a diagnosis of cirrhosis. COVID-19 occurredsignificantly lessamongpatients with cirrhosis (n = 15; 0.9%, p <.01) compared with the population without cirrhosis (n = 10,593; 1.8%). However, a large proportion (n = 6;40.0%) required a COVID-19 related hospitalization which was correlated with higher values of alanine aminotransferase (p <.01) and lactate dehydrogenase (p =.04). In addition, one-in-three (n = 2; 13.3%) required intensive therapy. Four patients died (26.7%) and mortality was associated with higher MELD scores, co-existing type 2 diabetes, and bacterial superinfections. Conclusion: In conclusion, patientswith cirrhosis may have a lower risk of COVID-19; but a higher risk of complications hereto and mortality.
Original language | English |
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Article number | 1881814 |
Journal | Scandinavian Journal of Gastroenterology |
Volume | 56 |
Issue number | 4 |
Pages (from-to) | 453-457 |
Number of pages | 5 |
ISSN | 0036-5521 |
DOIs | |
Publication status | Published - Apr 2021 |
Keywords
- COVID-19
- acute-on-chronic liver failure
- coronavirus disease 2019
- disease course
- epidemiology
- infectious diseases
- liver cirrhosis
- mortality
- population-based
- superinfections