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A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process

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DOI

  1. Inter-rater agreement and reliability of outcome measurement instruments and staging systems used in hidradenitis suppurativa

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Glucose metabolism in patients with psoriasis

    Research output: Contribution to journalReviewResearchpeer-review

  3. Cause-specific mortality in patients with psoriasis and psoriatic arthritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Prevalence of patients with self-reported hidradenitis suppurativa in a cohort of Danish blood donors: a cross-sectional study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. OMERACT Development of a Core Domain Set of Outcomes for Shared Decision-making Interventions

    Research output: Contribution to journalJournal articleResearchpeer-review

  • HIdradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC)
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BACKGROUND: There is no consensus on core outcome domains for hidradenitis suppurativa (HS). Heterogeneous outcome measure instruments in clinical trials likely leads to outcome-reporting bias and limits the ability to synthesize evidence.

OBJECTIVES: To achieve global multistakeholder consensus on a core outcome set (COS) of domains regarding what to measure in clinical trials for HS.

METHODS: Six stakeholder groups participated in a Delphi process that included five anonymous e-Delphi rounds and four face-to-face consensus meetings to reach consensus on the final COS. The aim was for a 1 : 1 ratio of patients to healthcare professionals (HCPs).

RESULTS: A total of 41 patients and 52 HCPs from 19 countries in four continents participated in the consensus process, which yielded a final COS that included five domains: pain, physical signs, HS-specific quality of life, global assessment and progression of course. A sixth domain, symptoms, was highly supported by patients and not by HCPs but is recommended for the core domain set.

CONCLUSIONS: Routine adoption of the COS in future HS trials should ensure that core outcomes of importance to both patients and HCPs are collected.

Original languageEnglish
JournalBritish Journal of Dermatology
Volume179
Issue number3
Pages (from-to)642-650
Number of pages9
ISSN0007-0963
DOIs
Publication statusPublished - Sep 2018

ID: 56061941