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A Contemporary Systematic Review on Repartition of HPV-Positivity in Oropharyngeal Cancer Worldwide

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@article{8142fc81dd2e4ef58f3662556d1279ab,
title = "A Contemporary Systematic Review on Repartition of HPV-Positivity in Oropharyngeal Cancer Worldwide",
abstract = "Significant variation in human papillomavirus (HPV) prevalence in oropharyngeal squamous cell carcinoma (OPSCC) across countries ranging from 11% in Brazil to 74% in New Zealand has been reported earlier. The aim of this study was to systematically review the most recently published studies on the occurrence of HPV in OPSCC globally. PubMed and Embase were systematically searched for articles assessing the occurrence of HPV+ OPSCC published between January 2016 and May 2021. Studies with a study period including 2015 and the following years were included. Both HPV DNA and/or p16 were accepted as indicators of HPV+ OPSCC. 31 studies were enrolled comprising 49,564 patients with OPSCC (range 12-42,024 patients per study) from 26 different countries covering all continents. The lowest occurrences of HPV+ OPSCC were observed in India (0%) and Spain (10%) and the highest occurrences were observed in Lebanon (85%) and Sweden (70%). We observed great variation in HPV prevalence in OPSCC worldwide varying from 0% to 85%. The highest occurrences of HPV+ OPSCC were found in general in Northern European countries, USA, Lebanon, China, and South Korea. We observed a trend of increase in HPV-positivity, indicating a mounting burden of HPV+ OPSCC.",
keywords = "Alphapapillomavirus/genetics, Global Health/trends, Humans, Oropharyngeal Neoplasms/epidemiology, Papillomavirus Infections/virology, Prevalence, Prognosis, Squamous Cell Carcinoma of Head and Neck/epidemiology, Oropharyngeal squamous cell carcinoma, Worldwide, Global, Human papillomavirus, HPV genotype, Oropharyngeal cancer, Head and neck cancer",
author = "Carlander, {Amanda F} and Jakobsen, {Kathrine K} and Bendtsen, {Simone K} and Martin Garset-Zamani and Lynggaard, {Charlotte D} and Jensen, {Jakob Schmidt} and Christian Gr{\o}nh{\o}j and Buchwald, {Christian von}",
year = "2021",
month = jul,
day = "9",
doi = "10.3390/v13071326",
language = "English",
volume = "13",
journal = "Viruses-Basel",
issn = "1999-4915",
publisher = "M D P I AG",
number = "7",

}

RIS

TY - JOUR

T1 - A Contemporary Systematic Review on Repartition of HPV-Positivity in Oropharyngeal Cancer Worldwide

AU - Carlander, Amanda F

AU - Jakobsen, Kathrine K

AU - Bendtsen, Simone K

AU - Garset-Zamani, Martin

AU - Lynggaard, Charlotte D

AU - Jensen, Jakob Schmidt

AU - Grønhøj, Christian

AU - Buchwald, Christian von

PY - 2021/7/9

Y1 - 2021/7/9

N2 - Significant variation in human papillomavirus (HPV) prevalence in oropharyngeal squamous cell carcinoma (OPSCC) across countries ranging from 11% in Brazil to 74% in New Zealand has been reported earlier. The aim of this study was to systematically review the most recently published studies on the occurrence of HPV in OPSCC globally. PubMed and Embase were systematically searched for articles assessing the occurrence of HPV+ OPSCC published between January 2016 and May 2021. Studies with a study period including 2015 and the following years were included. Both HPV DNA and/or p16 were accepted as indicators of HPV+ OPSCC. 31 studies were enrolled comprising 49,564 patients with OPSCC (range 12-42,024 patients per study) from 26 different countries covering all continents. The lowest occurrences of HPV+ OPSCC were observed in India (0%) and Spain (10%) and the highest occurrences were observed in Lebanon (85%) and Sweden (70%). We observed great variation in HPV prevalence in OPSCC worldwide varying from 0% to 85%. The highest occurrences of HPV+ OPSCC were found in general in Northern European countries, USA, Lebanon, China, and South Korea. We observed a trend of increase in HPV-positivity, indicating a mounting burden of HPV+ OPSCC.

AB - Significant variation in human papillomavirus (HPV) prevalence in oropharyngeal squamous cell carcinoma (OPSCC) across countries ranging from 11% in Brazil to 74% in New Zealand has been reported earlier. The aim of this study was to systematically review the most recently published studies on the occurrence of HPV in OPSCC globally. PubMed and Embase were systematically searched for articles assessing the occurrence of HPV+ OPSCC published between January 2016 and May 2021. Studies with a study period including 2015 and the following years were included. Both HPV DNA and/or p16 were accepted as indicators of HPV+ OPSCC. 31 studies were enrolled comprising 49,564 patients with OPSCC (range 12-42,024 patients per study) from 26 different countries covering all continents. The lowest occurrences of HPV+ OPSCC were observed in India (0%) and Spain (10%) and the highest occurrences were observed in Lebanon (85%) and Sweden (70%). We observed great variation in HPV prevalence in OPSCC worldwide varying from 0% to 85%. The highest occurrences of HPV+ OPSCC were found in general in Northern European countries, USA, Lebanon, China, and South Korea. We observed a trend of increase in HPV-positivity, indicating a mounting burden of HPV+ OPSCC.

KW - Alphapapillomavirus/genetics

KW - Global Health/trends

KW - Humans

KW - Oropharyngeal Neoplasms/epidemiology

KW - Papillomavirus Infections/virology

KW - Prevalence

KW - Prognosis

KW - Squamous Cell Carcinoma of Head and Neck/epidemiology

KW - Oropharyngeal squamous cell carcinoma

KW - Worldwide

KW - Global

KW - Human papillomavirus

KW - HPV genotype

KW - Oropharyngeal cancer

KW - Head and neck cancer

UR - http://www.scopus.com/inward/record.url?scp=85111083145&partnerID=8YFLogxK

U2 - 10.3390/v13071326

DO - 10.3390/v13071326

M3 - Journal article

C2 - 34372532

VL - 13

JO - Viruses-Basel

JF - Viruses-Basel

SN - 1999-4915

IS - 7

M1 - 1326

ER -

ID: 67742658