A computerised sampling strategy for therapeutic drug monitoring of lithium provides precise estimates and significantly reduces dose-finding time

Lotte Christine Groth Høgberg, Gesche Jürgens, Vivian Wederking Zederkof, Bettina Holgersson, John Erik Andersson, Kim Peder Dalhoff, Ejnar Bundgaard Larsen, Helle Riis Angelo

2 Citations (Scopus)

Abstract

The clinical benefit of implementing Bayesian approach for lithium drug monitoring was evaluated. Intervention group (N = 42) and historical control group (N = 55) patients were each divided into two groups: Dosage with immediate-release lithium carbonate or a sustained-release formulation, lithium citrate. Bayesian approach was performed in the intervention groups, and estimation of lithium steady-state trough concentration was obtained from non-steady-state blood sample, collected about 12 hr after the first lithium study dose. The estimate was compared with the actually measured steady-state concentration. In the control group, lithium monitoring was traditionally performed as steady-state blood sampling. Predicted and measured lithium concentrations were comparable. The desired lithium dose was reached significantly faster in the intervention group compared to control; 2.47 ± 2.22 days versus 9.96 ± 11.24 days (mean ± S.D.) (p = 0.0003). Bayesian approach was an advantage for the clinicians as a fast and safe aid to obtain the optimal lithium treatment dose.
Original languageEnglish
JournalBasic & clinical pharmacology & toxicology
Volume110
Issue number3
Pages (from-to)259-63
Number of pages5
ISSN1742-7835
DOIs
Publication statusPublished - 2012

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Antimanic Agents
  • Bayes Theorem
  • Citrates
  • Delayed-Action Preparations
  • Dose-Response Relationship, Drug
  • Drug Monitoring
  • Female
  • Humans
  • Lithium Carbonate
  • Male
  • Middle Aged
  • Prospective Studies
  • Retrospective Studies
  • Time Factors
  • Young Adult

Fingerprint

Dive into the research topics of 'A computerised sampling strategy for therapeutic drug monitoring of lithium provides precise estimates and significantly reduces dose-finding time'. Together they form a unique fingerprint.

Cite this