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The Capital Region of Denmark - a part of Copenhagen University Hospital
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A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

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For more than half a century, Denmark has maintained population-wide demographic, health care, and socioeconomic registers that provide detailed information on the interaction between all residents and the extensive national social services system. We leverage this resource to reconstruct the genealogy of the entire nation based on all individuals legally residing in Denmark since 1968. We cross-reference 6,691,426 individuals with nationwide health care registers to estimate heritability and genetic correlations of 10 broad diagnostic categories involving all major organs and systems. Heritability estimates for mental disorders were consistently the highest across demographic cohorts (average h 2 = 0.406, 95% CI = [0.403, 0.408]), whereas estimates for cancers were the lowest (average h 2 = 0.130, 95% CI = [0.125, 0.134]). The average genetic correlation of each of the 10 diagnostic categories with the other nine was highest for gastrointestinal conditions (average rg = 0.567, 95% CI = [0.566, 0.567]) and lowest for urogenital conditions (average rg = 0.386, 95% CI = [0.385, 0.388]). Mental, pulmonary, gastrointestinal, and neurological conditions had similar genetic correlation profiles.

Original languageEnglish
Article numbere2118688119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number6
ISSN0027-8424
DOIs
Publication statusPublished - 8 Feb 2022

Bibliographical note

Copyright © 2022 the Author(s). Published by PNAS.

ID: 74464275