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A Comprehensive Gene-Environment Interaction Analysis in Ovarian Cancer using Genome-wide Significant Common Variants

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  • Sehee Kim
  • Miao Wang
  • Jonathan P Tyrer
  • Allan Jensen
  • Ashley Wiensch
  • Gang Liu
  • Alice W Lee
  • Roberta B Ness
  • Maxwell Salvatore
  • Shelley S Tworoger
  • Alice S Whittemore
  • Hoda Anton-Culver
  • Weiva Sieh
  • Sara H Olson
  • Andrew Berchuck
  • Ellen L Goode
  • Marc T Goodman
  • Jennifer Anne Doherty
  • Georgia Chenevix-Trench
  • Mary Anne Rossing
  • Penelope M Webb
  • Graham G Giles
  • Kathryn L Terry
  • Argyrios Ziogas
  • Renée T Fortner
  • Usha Menon
  • Simon A Gayther
  • Anna H Wu
  • Honglin Song
  • Angela Brooks-Wilson
  • Elisa V Bandera
  • Linda S Cook
  • Daniel W Cramer
  • Roger L Milne
  • Stacey J Winham
  • Susanne K Kjaer
  • Francesmary Modugno
  • Pamela J Thompson
  • Jenny Chang-Claude
  • Holly R Harris
  • Joellen M Schildkraut
  • Nhu D Le
  • Nico Wentzensen
  • Britton Trabert
  • Estrid Høgdall
  • David Huntsman
  • Malcolm C Pike
  • Paul D P Pharoah
  • Celeste Leigh Pearce
  • Bhramar Mukherjee
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As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), this study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9,971 ovarian cancer cases and 15,566 controls from 17 case-control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs never) and rs13255292 (P-value = 3.48 x 10-4 ). Among women with the TT genotype for this variant, the odds ratio for OCP use was 0.53 (95% CI=0.46-0.60) compared to 0.71 (95%CI=0.66-0.77) for women with the CC genotype. When stratified by duration of OCP use, women with 1-5 years of OCP use exhibited differential protective benefit across genotypes. However, no interaction on either the multiplicative or additive scale was found to be statistically significant after multiple testing correction. The results suggest that OCP use may offer increased benefit for women who are carriers of the T allele in rs13255292. On the other hand, for women carrying the C allele in this variant, longer (5+ years) use of OCP may reduce the impact of carrying the risk allele of this SNP. Replication of this finding is needed. The study presents a comprehensive analytic framework for conducting gene-environment analysis in ovarian cancer. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalInternational Journal of Cancer
Volume144
Issue number9
Pages (from-to)2192-2205
Number of pages14
ISSN0020-7136
DOIs
Publication statusPublished - 1 May 2019

    Research areas

  • additive interaction, G × E, genetics, ovarian cancer

ID: 56088256