A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys

A Juul; K Sørensen; L Aksglaede; I Garn; E Rajpert-De Meyts; I Hullstein; P Hemmersbach; A M Ottesen

doi:10.1210/jc.2008-1984

A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys

A Juul, K Sørensen, L Aksglaede, I Garn, E Rajpert-De Meyts, I Hullstein, P Hemmersbach, A M Ottesen

Department of Growth and Reproduction

27 Citations (Scopus)

Abstract

Testosterone (T) is excreted in urine as water-soluble glucuronidated and sulfated conjugates. The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	94
Issue number	3
Pages (from-to)	1005-11
Number of pages	7
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2008-1984
Publication status	Published - 2009

Keywords

Adolescent
Adult
Child
Estradiol
Gene Deletion
Genotype
Glucuronosyltransferase
Humans
Male
Puberty
Testosterone

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10.1210/jc.2008-1984

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Juul, A., Sørensen, K., Aksglaede, L., Garn, I., Rajpert-De Meyts, E., Hullstein, I., Hemmersbach, P., & Ottesen, A. M. (2009). A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys. Journal of Clinical Endocrinology and Metabolism, 94(3), 1005-11. https://doi.org/10.1210/jc.2008-1984

A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys. / Juul, A; Sørensen, K; Aksglaede, L et al.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 3, 2009, p. 1005-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Juul, A, Sørensen, K, Aksglaede, L, Garn, I, Rajpert-De Meyts, E, Hullstein, I, Hemmersbach, P & Ottesen, AM 2009, 'A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 3, pp. 1005-11. https://doi.org/10.1210/jc.2008-1984

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abstract = "Testosterone (T) is excreted in urine as water-soluble glucuronidated and sulfated conjugates. The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys.",

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AU - Aksglaede, L

AU - Garn, I

AU - Rajpert-De Meyts, E

AU - Hullstein, I

AU - Hemmersbach, P

AU - Ottesen, A M

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KW - Adolescent

KW - Adult

KW - Child

KW - Estradiol

KW - Gene Deletion

KW - Genotype

KW - Glucuronosyltransferase

KW - Humans

KW - Male

KW - Puberty

KW - Testosterone

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SN - 0021-972X

IS - 3

ER -

A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys

Abstract

Keywords

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