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The Capital Region of Denmark - a part of Copenhagen University Hospital
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A biomarker profile for predicting efficacy of cisplatin-vinorelbine therapy in malignant pleural mesothelioma

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  2. EP1.08-07 Correlation Between Genetic Profiling and Response in Danish ALK-Positive NSCLC Patients Treated with Crizotinib

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Malignant pleural mesothelioma (MPM) has a dismal prognosis. Treatment results may be improved by biomarker-directed therapy. We investigated the baseline expression and impact on outcome of predictive biomarkers ERCC1, BRCA1, and class III β-tubulin in a cohort of MPM patients treated with cisplatin-vinorelbine. We further explored the possibility of combining markers into a treatment-response profile to increase the predictive power.
Original languageEnglish
JournalCancer Chemotherapy and Pharmacology
Volume70
Issue number5
Pages (from-to)743-54
Number of pages12
ISSN0344-5704
DOIs
Publication statusPublished - 2012

ID: 36590537