TY - JOUR
T1 - A biomarker profile for predicting efficacy of cisplatin-vinorelbine therapy in malignant pleural mesothelioma
AU - Zimling, Zarah Glad
AU - Sørensen, Jens Benn
AU - Gerds, Thomas Alexander
AU - Bech, Cecilia
AU - Andersen, Claus Bøgelund
AU - Santoni-Rugiu, Eric
PY - 2012
Y1 - 2012
N2 - Malignant pleural mesothelioma (MPM) has a dismal prognosis. Treatment results may be improved by biomarker-directed therapy. We investigated the baseline expression and impact on outcome of predictive biomarkers ERCC1, BRCA1, and class III β-tubulin in a cohort of MPM patients treated with cisplatin-vinorelbine. We further explored the possibility of combining markers into a treatment-response profile to increase the predictive power.
AB - Malignant pleural mesothelioma (MPM) has a dismal prognosis. Treatment results may be improved by biomarker-directed therapy. We investigated the baseline expression and impact on outcome of predictive biomarkers ERCC1, BRCA1, and class III β-tubulin in a cohort of MPM patients treated with cisplatin-vinorelbine. We further explored the possibility of combining markers into a treatment-response profile to increase the predictive power.
U2 - 10.1007/s00280-012-1965-0
DO - 10.1007/s00280-012-1965-0
M3 - Journal article
C2 - 22960937
VL - 70
SP - 743
EP - 754
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology
SN - 0344-5704
IS - 5
ER -