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A∂- and not C-Fibers Mediate Thermal Hyperalgesia to Short Laser Stimuli After Burn Injury in Man

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  1. Itch sensitization? A systematic review of studies using quantitative sensory testing in patients with chronic itch

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  2. CACNG2 polymorphisms associate with chronic pain following mastectomy

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  3. Postoperative pain, analgesia, and recovery-bedfellows that cannot be ignored

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  4. Alloknesis and hyperknesis-mechanisms, assessment methodology, and clinical implications of itch sensitization

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  5. Heterozygous Mutations in Gtp-Cyclohydrolase-1 Reduce Bh4 Biosynthesis but Not Pain Sensitivity

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  1. Dexamethasone Dose and Early Postoperative Recovery after Mastectomy: A Double-blind, Randomized Trial

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  2. Alvimopan and outcome after colectomy?

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  3. Challenges in optimising recovery after emergency laparotomy

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  4. Enhanced postoperative recovery: good from afar, but far from good?

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It remains unclear which nerve fibers are responsible for mediating hyperalgesia following skin injury. Here, we examined the role of A∂- and C-fibers in inflammatory hyperalgesia following a first-degree burn injury. A CO2-laser delivered ultrafast short constant-temperature heat pulses to the upper part of the lower leg, to stimulate selectively the relatively fast conducting thinly myelinated A∂ and the slowly conducting unmyelinated C-fibers. Participants were asked to respond as fast as possible whenever they detected a thermal stimulus. Thresholds and reaction times to selective Aδ- and C-fiber activations were measured in the conditioned and the surrounding intact skin, at pre-injury, and 1- and 24-hours post-injury. First-degree burn injury caused a significant decrease in Aδ-fiber detection thresholds and a significant increase in the proportion of Aδ-fiber mediated responses in the inflamed area 24 hours, but not 1 hour, following burn injury. No changes in heat perception were observed in the intact skin surrounding the injury. No group differences in C-fiber mediated sensations were observed. Our findings indicate that quickly-adapting Aδ-fibers but not quickly-adapting C-fibers are sensitized when activated by short and ultra-fast heat stimuli following skin burn injury. Our results further show that this change occurs between 1- and 24-hours post-injury and that it does not extend to the skin surrounding the injury.

Original languageEnglish
JournalPain
Volume159
Issue number11
Pages (from-to)2331-2338
Number of pages8
ISSN0304-3959
DOIs
Publication statusPublished - 2018

ID: 54756155