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The Capital Region of Denmark - a part of Copenhagen University Hospital
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A 9-week randomized trial comparing a chronotherapeutic intervention (wake and light therapy) to exercise in major depressive disorder patients treated with duloxetine

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  1. Seasonal variation in neurohormones, mood and sleep in patients with primary open angle glaucoma - implications of the ipRGC-system

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  2. Light therapy for seasonal affective disorder in visual impairment and blindness - a pilot study

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  3. Reducing the rate of psychiatric Re-ADMISsions in Bipolar Disorder using smartphones The RADMIS trial

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  4. Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation

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The onset of action of antidepressants often takes 4 to 6 weeks. The antidepressant effect of wake therapy (sleep deprivation) comes within hours but carries a risk of relapse. The objective of this study was to investigate whether a new chronotherapeutic intervention combining wake therapy with bright light therapy and sleep time stabilization could induce a rapid and sustained augmentation of response and remission in major depressive disorder.
Original languageEnglish
JournalPrimary Care Companion to C N S Disorders
Volume73
Issue number9
Pages (from-to)1234-42
Number of pages9
ISSN2155-7772
DOIs
Publication statusPublished - 2012

    Research areas

  • Adult, Aged, Antidepressive Agents, Combined Modality Therapy, Denmark, Depressive Disorder, Major, Exercise, Female, Humans, Logistic Models, Male, Middle Aged, Phototherapy, Prospective Studies, Seasons, Single-Blind Method, Sleep Phase Chronotherapy, Thiophenes

ID: 36881539