Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

A 10-Year Follow-up Study of the Natural History of Perianal Crohn's Disease in a Danish Population-Based Inception Cohort

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Inflammatory Bowel Disease and Parkinson's Disease: A Nationwide Swedish Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Changing Infliximab Prescription Patterns in Inflammatory Bowel Disease: A Population-Based Cohort Study, 1999-2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Individualized Infliximab Treatment Guided by Patient-managed eHealth in Children and Adolescents with Inflammatory Bowel Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Plasma calprotectin is superior to serum calprotectin as a biomarker of intestinal inflammation in ulcerative colitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Enhanced processing of von Willebrand factor reflects disease severity and discriminates severe portal hypertension in cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Health-related quality of life in inflammatory bowel disease in a Danish population-based inception cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Impact of Genes and the Environment on the Pathogenesis and Disease Course of Inflammatory Bowel Disease

    Research output: Contribution to journalReviewResearchpeer-review

  5. Indocyanine green retention test in cirrhosis and portal hypertension: Accuracy and relation to severity of disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: Perianal complications in patients with Crohn's disease are common and have a negative impact on the patients' quality of life. Data about the long-term disease course of perianal Crohn's disease in the era of biological treatment are limited. In this population-based cohort study, we sought to investigate the occurrence, clinical risk factors, and disease course of perianal disease.

Methods: A total of 213 Crohn's disease patients were included in a prospective population-based inception cohort. Data were retrieved from medical records and national health administrative databases. Perianal disease was defined as a perianal fistula and/or abscess. Associations between outcomes and covariates were analyzed by Cox regression analysis.

Results: A total of 48 (22.5%) patients developed perianal disease after 10 years. Colonic disease location (hazard ratio [HR], 1.99; 95% confidence interval [CI], 1.01-3.92) and penetrating behavior (HR, 5.65; 95% CI, 2.65-12.03) were associated with the development of perianal disease. The cumulative risk of undergoing abdominal surgery was 51% after 10 years. Patients with perianal disease had a higher rate of resection (HR, 3.92; 95% CI, 1.86-8.67) and hospitalization (HR, 1.01; 95% CI, 1.00-1.01). There was no significant difference in the rate of sick leave, unemployment, or disability pension between patients with and without perianal disease.

Conclusions: Patients with perianal disease carry a higher risk of surgery and hospitalization, and this suggests a more severe disease course and poorer prognosis among these patients, even in the era of biological treatment. These findings underline the importance of optimizing treatment strategies for patients with perianal disease.

Original languageEnglish
JournalInflammatory Bowel Diseases
Volume25
Issue number7
Pages (from-to)1227-1236
ISSN1078-0998
DOIs
Publication statusPublished - Jul 2019

ID: 55903988