A 10-year follow up of reproductive function in women treated for childhood cancer

33 Citations (Scopus)

Abstract

Previously, this study group found that female childhood cancer survivors could be at risk of early cessation of fertility. The aim of the present study was to evaluate reproductive function in the same group of survivors 10 years after the initial study. Of the original cohort of 100, 71 were re-examined. Thirty-six survivors reported regular menstrual cycles. When they were compared with 210 controls, they differed significantly in antral follicle count (AFC) (median 15 versus 18, P=0.047) but not in anti-Müllerian hormone (AMH) (median 13.0 versus 17.8pmol/l). Survivors cured with minimal gonadotoxic treatment had significantly higher AMH and AFC compared with survivors cured with either potentially gonadotoxic treatment or treatment including alkylating chemotherapy and ovarian irradiation (20.0, 5.8 and
Original languageEnglish
JournalReproductive BioMedicine Online
Volume27
Issue number2
Pages (from-to)192-200
Number of pages9
ISSN1472-6483
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Dive into the research topics of 'A 10-year follow up of reproductive function in women treated for childhood cancer'. Together they form a unique fingerprint.

Cite this