(99m)Tc-aprotinin - optimisation and validation of radiolabelling kits for routine preparation for diagnostic imaging of amyloidosis

Charlotte Denholt; Nic Gillings

doi:10.1002/jlcr.3381

(99m)Tc-aprotinin - optimisation and validation of radiolabelling kits for routine preparation for diagnostic imaging of amyloidosis

Department of Clinical Physiology and Nuclear Medicine

1 Citation (Scopus)

Abstract

Technetium-99m aprotinin was prepared from an optimised radiolabelling kit formulation containing aprotinin, alkaline buffer and stannous chloride (reducing agent) and radiolabelled using (99m) Tc-pertechnetate. The labelling was achieved within 25 min, with radiochemical purities of >98%.

Original language	English
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	59
Issue number	4
Pages (from-to)	171-4
Number of pages	4
ISSN	0362-4803
DOIs	https://doi.org/10.1002/jlcr.3381
Publication status	Published - Apr 2016

Keywords

Amyloidosis
Aprotinin
Diagnostic Imaging
Isotope Labeling
Radiochemistry
Technetium
Journal Article

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10.1002/jlcr.3381

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title = "(99m)Tc-aprotinin - optimisation and validation of radiolabelling kits for routine preparation for diagnostic imaging of amyloidosis",

abstract = "Technetium-99m aprotinin was prepared from an optimised radiolabelling kit formulation containing aprotinin, alkaline buffer and stannous chloride (reducing agent) and radiolabelled using (99m) Tc-pertechnetate. The labelling was achieved within 25 min, with radiochemical purities of >98\%.",

keywords = "Amyloidosis, Aprotinin, Diagnostic Imaging, Isotope Labeling, Radiochemistry, Technetium, Journal Article",

author = "Charlotte Denholt and Nic Gillings",

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year = "2016",

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AU - Gillings, Nic

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AB - Technetium-99m aprotinin was prepared from an optimised radiolabelling kit formulation containing aprotinin, alkaline buffer and stannous chloride (reducing agent) and radiolabelled using (99m) Tc-pertechnetate. The labelling was achieved within 25 min, with radiochemical purities of >98%.

KW - Amyloidosis

KW - Aprotinin

KW - Diagnostic Imaging

KW - Isotope Labeling

KW - Radiochemistry

KW - Technetium

KW - Journal Article

U2 - 10.1002/jlcr.3381

DO - 10.1002/jlcr.3381

M3 - Journal article

C2 - 26923297

SN - 0362-4803

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JO - Journal of Labelled Compounds and Radiopharmaceuticals

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IS - 4

ER -

(99m)Tc-aprotinin - optimisation and validation of radiolabelling kits for routine preparation for diagnostic imaging of amyloidosis

Abstract

Keywords

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