7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia

Magally Romero-Tabarez; Rolf Jansen; Marita Sylla; Heinrich Lünsdorf; Susanne Häussler; Dwi A Santosa; Kenneth N Timmis; Gabriella Molinari

doi:10.1128/AAC.50.5.1701-1709.2006

7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia

Magally Romero-Tabarez, Rolf Jansen, Marita Sylla, Heinrich Lünsdorf, Susanne Häussler, Dwi A Santosa, Kenneth N Timmis, Gabriella Molinari

132 Citations (Scopus)

Abstract

We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	5
Pages (from-to)	1701-9
Number of pages	9
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.50.5.1701-1709.2006
Publication status	Published - May 2006
Externally published	Yes

Keywords

Animals
Anti-Bacterial Agents/pharmacology
Bacillus subtilis/chemistry
Burkholderia cepacia/drug effects
Drug Resistance, Multiple/genetics
Enterococcus/drug effects
Enterococcus faecium/drug effects
Genetic Variation
HeLa Cells
Humans
Kinetics
L Cells
Macrolides/chemistry
Methicillin Resistance
Mice
Microbial Sensitivity Tests
Molecular Structure
Staphylococcus aureus/drug effects
Vancomycin Resistance

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Romero-Tabarez, M., Jansen, R., Sylla, M., Lünsdorf, H., Häussler, S., Santosa, D. A., Timmis, K. N., & Molinari, G. (2006). 7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. Antimicrobial Agents and Chemotherapy, 50(5), 1701-9. https://doi.org/10.1128/AAC.50.5.1701-1709.2006

7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. / Romero-Tabarez, Magally; Jansen, Rolf; Sylla, Marita et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 5, 05.2006, p. 1701-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Romero-Tabarez, M, Jansen, R, Sylla, M, Lünsdorf, H, Häussler, S, Santosa, DA, Timmis, KN & Molinari, G 2006, '7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia', Antimicrobial Agents and Chemotherapy, vol. 50, no. 5, pp. 1701-9. https://doi.org/10.1128/AAC.50.5.1701-1709.2006

Romero-Tabarez M, Jansen R, Sylla M, Lünsdorf H, Häussler S, Santosa DA et al. 7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. Antimicrobial Agents and Chemotherapy. 2006 May;50(5):1701-9. doi: 10.1128/AAC.50.5.1701-1709.2006

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abstract = "We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.",

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author = "Magally Romero-Tabarez and Rolf Jansen and Marita Sylla and Heinrich L{\"u}nsdorf and Susanne H{\"a}ussler and Santosa, \{Dwi A\} and Timmis, \{Kenneth N\} and Gabriella Molinari",

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AU - Romero-Tabarez, Magally

AU - Jansen, Rolf

AU - Sylla, Marita

AU - Lünsdorf, Heinrich

AU - Häussler, Susanne

AU - Santosa, Dwi A

AU - Timmis, Kenneth N

AU - Molinari, Gabriella

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AB - We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.

KW - Animals

KW - Anti-Bacterial Agents/pharmacology

KW - Bacillus subtilis/chemistry

KW - Burkholderia cepacia/drug effects

KW - Drug Resistance, Multiple/genetics

KW - Enterococcus/drug effects

KW - Enterococcus faecium/drug effects

KW - Genetic Variation

KW - HeLa Cells

KW - Humans

KW - Kinetics

KW - L Cells

KW - Macrolides/chemistry

KW - Methicillin Resistance

KW - Mice

KW - Microbial Sensitivity Tests

KW - Molecular Structure

KW - Staphylococcus aureus/drug effects

KW - Vancomycin Resistance

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U2 - 10.1128/AAC.50.5.1701-1709.2006

DO - 10.1128/AAC.50.5.1701-1709.2006

M3 - Journal article

C2 - 16641438

SN - 0066-4804

VL - 50

SP - 1701

EP - 1709

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia

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Keywords

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