Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

30-day and long-term outcome following salvage surgery for squamous cell carcinoma of the anus

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Near-infrared fluorescence imaging improves the nodal yield in neck dissection in oral cavity cancer - A randomized study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Waiting time to surgery and pancreatic cancer survival: A nationwide population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Reply to: Adequate use of radioactive seed localisation. Where we are?

    Research output: Contribution to journalComment/debateResearch

  5. Triage for selection to colonoscopy?

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Circumferential Resection Margin After Laparoscopic and Open Rectal Resection: A Nationwide Propensity Score Matched Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Long-term wind turbine noise exposure and the risk of incident atrial fibrillation in the Danish Nurse cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Validation of a register-based algorithm for recurrence in rectal cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Squamous cell carcinoma of the anus (SCCA) is a rare condition. First line treatment is combined chemo-radio therapy. As many as a third of patients undergoing CRT will experience recurrence. These patients often undergo salvage surgery with an extended abdominoperineal excision. The aims of this study were 1) to assess and evaluate 30-day postoperative morbidity and mortality after salvage surgery for recurrent SCCA, and furthermore, 2) to examine secondary recurrence and long-term mortality after salvage surgery for recurrent SCCA.

MATERIAL AND METHODS: Retrospective evaluation of all patients undergoing salvage surgery for SCCA at Copenhagen University Hospital Herlev between 1st of January 2011 and 31th December 2016.

RESULTS: Forty-seven patients were identified. 30-day postoperative mortality was 4%. The most common postoperative complication was perineal wound defects. Within the follow-up period of median 20 (1-80) months, secondary recurrence occurred in 30% of patients. Median disease free survival was 32 months. Secondary recurrence was significantly more frequent in patients with R1 resection and pN ≥ 1. Within the follow-up period of median 25 (0-80) months, mortality was 40%. Overall median survival was 39 months. Secondary recurrence was associated with a significantly higher risk of death within the follow-up period.

CONCLUSION: Salvage surgery for relapse of squamous cell carcinoma of the anus is a safe procedure with a good short-term outcome. Secondary recurrence was more frequent in patients with R1-resection and pN ≥ 1. More than one third of the patients died within the follow-up period, and mortality was significantly higher in the group of patients with secondary recurrence.

Original languageEnglish
JournalEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Volume44
Issue number10
Pages (from-to)1518-1521
Number of pages4
ISSN0748-7983
DOIs
Publication statusPublished - Oct 2018

    Research areas

  • Adult, Aged, Aged, 80 and over, Anus Neoplasms/surgery, Carcinoma, Squamous Cell/surgery, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/surgery, Retrospective Studies, Salvage Therapy/adverse effects, Survival Rate, Time Factors, Treatment Outcome

ID: 56359855