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2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

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Hansen, Katrine B ; Rosenkilde, Mette Marie ; Knop, Filip K ; Wellner, Niels ; Diep, Thi Ai ; Rehfeld, Jens F ; Andersen, Ulrik B ; Holst, Jens Juul ; Hansen, Elo Harald. / 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 9. pp. E1409-17.

Bibtex

@article{6cdd155feba44dcaa31880504af6016b,
title = "2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans",
abstract = "Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.",
keywords = "Adult, Blood Glucose, Cyclic AMP, Enteroendocrine Cells, Glucagon-Like Peptide 1, Glycerides, Humans, Male, Oleic Acids, Receptors, G-Protein-Coupled",
author = "Hansen, {Katrine B} and Rosenkilde, {Mette Marie} and Knop, {Filip K} and Niels Wellner and Diep, {Thi Ai} and Rehfeld, {Jens F} and Andersen, {Ulrik B} and Holst, {Jens Juul} and Hansen, {Elo Harald}",
year = "2011",
doi = "10.1210/jc.2011-0647",
language = "English",
volume = "96",
pages = "E1409--17",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "9",

}

RIS

TY - JOUR

T1 - 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

AU - Hansen, Katrine B

AU - Rosenkilde, Mette Marie

AU - Knop, Filip K

AU - Wellner, Niels

AU - Diep, Thi Ai

AU - Rehfeld, Jens F

AU - Andersen, Ulrik B

AU - Holst, Jens Juul

AU - Hansen, Elo Harald

PY - 2011

Y1 - 2011

N2 - Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.

AB - Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.

KW - Adult

KW - Blood Glucose

KW - Cyclic AMP

KW - Enteroendocrine Cells

KW - Glucagon-Like Peptide 1

KW - Glycerides

KW - Humans

KW - Male

KW - Oleic Acids

KW - Receptors, G-Protein-Coupled

U2 - 10.1210/jc.2011-0647

DO - 10.1210/jc.2011-0647

M3 - Journal article

VL - 96

SP - E1409-17

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 9

ER -

ID: 33192076