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2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes

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@article{c8f07761f2e04b059dfb62768e22bb69,
title = "2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes",
abstract = "Objectives: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion. Methods: We studied 6 elderly male athletes (61 ± 8 years (mean ± SD); baseline (Formula presented.)O2max 48 ± 5 ml·kg−1·min−1) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km. Results: Data collected after the cessation of exercise on the 14th day revealed significant increases in average size of the left atrium (3.5 ± 0.4 to 4.0 ± 0.3 cm; p = 0.02) and left ventricular end systolic volume (47 ± 2 to 52 ± 5 ml; p = 0.004), with no other significant changes in cardiac size or function. Small, transient increases in cardiac biomarkers (troponin T, creatine kinase myocardial band, and N-terminal pro-brain natriuretic peptide) (p < 0.01) were observed 2 h after completion of cycling but no changes in systolic (including strain-analyses) or diastolic cardiac function were observed at rest. (Formula presented.)O2max was significantly lower at the 28 h time point than at baseline (p < 0.02). Plasma concentrations of total- (p < 0.01) and low-density lipoprotein-cholesterol (p < 0.01) were markedly lower after exercise. Systolic blood pressure was unchanged, but diastolic pressure was significantly lower after exercise than at baseline. Conclusions: The results suggest that repeated moderate intensity exercise in elderly men was associated with a transient increase in cardiac biomarkers while cardiac function remained unaltered. A favorable reduction in blood lipids and diastolic blood pressure were seen for >28 h after the end of activity. An unexplained symptomless severe plasma hyponatremia developed in 3 of 6 subjects 28 h after the end of activity.",
keywords = "blood lipids, blood pressure, echocardiography, long-distance cycling, Master athletes",
author = "Thomas Morville and Mads Rosenkilde and Nick Mattsson and Flemming Dela and Helge, {J{\o}rn W.} and Rasmusen, {Hanne K.}",
year = "2018",
month = "5",
day = "28",
doi = "10.1080/00913847.2018.1477403",
language = "English",
volume = "46",
pages = "263--268",
journal = "Physician and Sportsmedicine",
issn = "0091-3847",
publisher = "J T E Multimedia, LLC",
number = "3",

}

RIS

TY - JOUR

T1 - 2706 km cycling in 2 weeks

T2 - effects on cardiac function in 6 elderly male athletes

AU - Morville, Thomas

AU - Rosenkilde, Mads

AU - Mattsson, Nick

AU - Dela, Flemming

AU - Helge, Jørn W.

AU - Rasmusen, Hanne K.

PY - 2018/5/28

Y1 - 2018/5/28

N2 - Objectives: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion. Methods: We studied 6 elderly male athletes (61 ± 8 years (mean ± SD); baseline (Formula presented.)O2max 48 ± 5 ml·kg−1·min−1) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km. Results: Data collected after the cessation of exercise on the 14th day revealed significant increases in average size of the left atrium (3.5 ± 0.4 to 4.0 ± 0.3 cm; p = 0.02) and left ventricular end systolic volume (47 ± 2 to 52 ± 5 ml; p = 0.004), with no other significant changes in cardiac size or function. Small, transient increases in cardiac biomarkers (troponin T, creatine kinase myocardial band, and N-terminal pro-brain natriuretic peptide) (p < 0.01) were observed 2 h after completion of cycling but no changes in systolic (including strain-analyses) or diastolic cardiac function were observed at rest. (Formula presented.)O2max was significantly lower at the 28 h time point than at baseline (p < 0.02). Plasma concentrations of total- (p < 0.01) and low-density lipoprotein-cholesterol (p < 0.01) were markedly lower after exercise. Systolic blood pressure was unchanged, but diastolic pressure was significantly lower after exercise than at baseline. Conclusions: The results suggest that repeated moderate intensity exercise in elderly men was associated with a transient increase in cardiac biomarkers while cardiac function remained unaltered. A favorable reduction in blood lipids and diastolic blood pressure were seen for >28 h after the end of activity. An unexplained symptomless severe plasma hyponatremia developed in 3 of 6 subjects 28 h after the end of activity.

AB - Objectives: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion. Methods: We studied 6 elderly male athletes (61 ± 8 years (mean ± SD); baseline (Formula presented.)O2max 48 ± 5 ml·kg−1·min−1) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km. Results: Data collected after the cessation of exercise on the 14th day revealed significant increases in average size of the left atrium (3.5 ± 0.4 to 4.0 ± 0.3 cm; p = 0.02) and left ventricular end systolic volume (47 ± 2 to 52 ± 5 ml; p = 0.004), with no other significant changes in cardiac size or function. Small, transient increases in cardiac biomarkers (troponin T, creatine kinase myocardial band, and N-terminal pro-brain natriuretic peptide) (p < 0.01) were observed 2 h after completion of cycling but no changes in systolic (including strain-analyses) or diastolic cardiac function were observed at rest. (Formula presented.)O2max was significantly lower at the 28 h time point than at baseline (p < 0.02). Plasma concentrations of total- (p < 0.01) and low-density lipoprotein-cholesterol (p < 0.01) were markedly lower after exercise. Systolic blood pressure was unchanged, but diastolic pressure was significantly lower after exercise than at baseline. Conclusions: The results suggest that repeated moderate intensity exercise in elderly men was associated with a transient increase in cardiac biomarkers while cardiac function remained unaltered. A favorable reduction in blood lipids and diastolic blood pressure were seen for >28 h after the end of activity. An unexplained symptomless severe plasma hyponatremia developed in 3 of 6 subjects 28 h after the end of activity.

KW - blood lipids

KW - blood pressure

KW - echocardiography

KW - long-distance cycling

KW - Master athletes

UR - http://www.scopus.com/inward/record.url?scp=85047480561&partnerID=8YFLogxK

U2 - 10.1080/00913847.2018.1477403

DO - 10.1080/00913847.2018.1477403

M3 - Journal article

VL - 46

SP - 263

EP - 268

JO - Physician and Sportsmedicine

JF - Physician and Sportsmedicine

SN - 0091-3847

IS - 3

ER -

ID: 54834027