2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

Katrine B Hansen, Mette Marie Rosenkilde, Filip K Knop, Niels Wellner, Thi Ai Diep, Jens F Rehfeld, Ulrik B Andersen, Jens Juul Holst, Elo Harald Hansen

227 Citations (Scopus)

Abstract

Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number9
Pages (from-to)E1409-17
ISSN0021-972X
DOIs
Publication statusPublished - 2011

Keywords

  • Adult
  • Blood Glucose
  • Cyclic AMP
  • Enteroendocrine Cells
  • Glucagon-Like Peptide 1
  • Glycerides
  • Humans
  • Male
  • Oleic Acids
  • Receptors, G-Protein-Coupled

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