164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study

Amar A Sethi; Anne Tybjaerg-Hansen; Gorm B Jensen; Børge G Nordestgaard

164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study

Amar A Sethi, Anne Tybjaerg-Hansen, Gorm B Jensen, Børge G Nordestgaard

20 Citations (Scopus)

Abstract

Since beta2-adrenergic receptors are important regulators of blood pressure, genetic variation in this receptor could explain risk of elevated blood pressure in selected individuals. We tested the hypothesis that Gly16Arg, Gln27Glu, and Thr164Ile in the beta2-adrenergic receptor gene associated with elevated blood pressure.

Original language	English
Journal	Pharmacogenet Genomics
Volume	15
Issue number	9
Pages (from-to)	633-45
Number of pages	13
Publication status	Published - 2005

Keywords

Alleles
Arginine
Blood Pressure
Body Mass Index
Denmark
Female
Gene Expression Regulation
Gene Frequency
Genetic Variation
Genotype
Glutamic Acid
Glutamine
Glycine
Haplotypes
Heart Rate
Heterozygote
Humans
Hypertension
Isoleucine
Linkage Disequilibrium
Male
Receptors, Adrenergic, beta-2
Risk
Risk Factors
Sequence Analysis, DNA
Sex Factors
Time Factors

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Cite this

Sethi, A. A., Tybjaerg-Hansen, A., Jensen, G. B., & Nordestgaard, B. G. (2005). 164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study. Pharmacogenet Genomics, 15(9), 633-45. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041242&query_hl=1&itool=pubmed_docsum

Sethi, AA, Tybjaerg-Hansen, A, Jensen, GB & Nordestgaard, BG 2005, '164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study', Pharmacogenet Genomics, vol. 15, no. 9, pp. 633-45. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16041242&query_hl=1&itool=pubmed_docsum>

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abstract = "Since beta2-adrenergic receptors are important regulators of blood pressure, genetic variation in this receptor could explain risk of elevated blood pressure in selected individuals. We tested the hypothesis that Gly16Arg, Gln27Glu, and Thr164Ile in the beta2-adrenergic receptor gene associated with elevated blood pressure.",

keywords = "Alleles, Arginine, Blood Pressure, Body Mass Index, Denmark, Female, Gene Expression Regulation, Gene Frequency, Genetic Variation, Genotype, Glutamic Acid, Glutamine, Glycine, Haplotypes, Heart Rate, Heterozygote, Humans, Hypertension, Isoleucine, Linkage Disequilibrium, Male, Receptors, Adrenergic, beta-2, Risk, Risk Factors, Sequence Analysis, DNA, Sex Factors, Time Factors",

author = "Sethi, {Amar A} and Anne Tybjaerg-Hansen and Jensen, {Gorm B} and Nordestgaard, {B{\o}rge G}",

year = "2005",

language = "English",

volume = "15",

pages = "633--45",

journal = "Pharmacogenet Genomics",

issn = "1744-6880",

publisher = "Lippincott Williams and Wilkins",

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T1 - 164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study

AU - Sethi, Amar A

AU - Tybjaerg-Hansen, Anne

AU - Jensen, Gorm B

AU - Nordestgaard, Børge G

PY - 2005

Y1 - 2005

N2 - Since beta2-adrenergic receptors are important regulators of blood pressure, genetic variation in this receptor could explain risk of elevated blood pressure in selected individuals. We tested the hypothesis that Gly16Arg, Gln27Glu, and Thr164Ile in the beta2-adrenergic receptor gene associated with elevated blood pressure.

AB - Since beta2-adrenergic receptors are important regulators of blood pressure, genetic variation in this receptor could explain risk of elevated blood pressure in selected individuals. We tested the hypothesis that Gly16Arg, Gln27Glu, and Thr164Ile in the beta2-adrenergic receptor gene associated with elevated blood pressure.

KW - Alleles

KW - Arginine

KW - Blood Pressure

KW - Body Mass Index

KW - Denmark

KW - Female

KW - Gene Expression Regulation

KW - Gene Frequency

KW - Genetic Variation

KW - Genotype

KW - Glutamic Acid

KW - Glutamine

KW - Glycine

KW - Haplotypes

KW - Heart Rate

KW - Heterozygote

KW - Humans

KW - Hypertension

KW - Isoleucine

KW - Linkage Disequilibrium

KW - Male

KW - Receptors, Adrenergic, beta-2

KW - Risk

KW - Risk Factors

KW - Sequence Analysis, DNA

KW - Sex Factors

KW - Time Factors

M3 - Journal article

C2 - 16041242

SN - 1744-6880

VL - 15

SP - 633

EP - 645

JO - Pharmacogenet Genomics

JF - Pharmacogenet Genomics

IS - 9

ER -

164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study

Abstract

Keywords

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