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[11 C]raclopride positron emission tomography study of dopamine-D2/3 receptor binding in patients with severe major depressive episodes before and after electroconvulsive therapy and compared to control subjects

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  • Mikael Tiger
  • Jonas Svensson
  • Benny Liberg
  • Tomoyuki Saijo
  • Martin Schain
  • Christer Halldin
  • Lars Farde
  • Johan Lundberg
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AIM: The aim of the study was to test: (i) if D2 /D3 binding in three functional subsections of striatum is different in patients with severe major depressive episodes than in controls; and (ii) if this difference is normalized after electroconvulsive therapy (ECT).

METHODS: Nine inpatients were examined with positron emission tomography (PET) and the radioligand [11 C]raclopride before and after an average of 8.4 ECT sessions. Treatment response was assessed using the Montgomery-Åsberg Depression Rating Scale. Nine age- and sex-matched controls were examined twice with PET and [11 C]raclopride.

RESULTS: [11 C]raclopride binding was significantly lower in all three subsections of striatum in patients compared to controls (Cohen's dz , 1.14-1.68; P = 0.003-0.027). Montgomery-Åsberg Depression Ratings decreased significantly after ECT (P < 0.001; Cohen's dz , 2.9). ECT had no statistically significant effect on [11 C]raclopride binding, although post-ECT binding estimates were more similar to those obtained in controls in all subsections of striatum.

CONCLUSION: Using PET and [11 C]raclopride, we found support for the notion that severe major depressive episodes are associated with significantly lower dopamine D2 /D3 binding in all three subsections of striatum compared to controls. We noted no significant effect on D2 /D3 binding in the patient group after response to ECT.

Original languageEnglish
JournalPsychiatry and Clinical Neurosciences
Volume74
Issue number4
Pages (from-to)263-269
Number of pages7
ISSN1323-1316
DOIs
Publication statusPublished - Apr 2020

    Research areas

  • Adult, Aged, Brain Mapping, Carbon Radioisotopes, Corpus Striatum, Depressive Disorder, Major/physiopathology, Dopamine/metabolism, Dopamine Antagonists/pharmacology, Electroconvulsive Therapy, Female, Humans, Male, Middle Aged, Positron-Emission Tomography, Protein Binding, Raclopride/pharmacology, Receptors, Dopamine D2/metabolism, Receptors, Dopamine D3/metabolism, positron-emission tomography, electroconvulsive therapy, raclopride, depression, dopamine

ID: 60097047