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The Capital Region of Denmark - a part of Copenhagen University Hospital

Switching From Zidovudine to an NNRTI or Lopinavir/Ritonavir in Patients Treated With Zidovudine/ Lamivudine/Abacavir. Influence on Metabolic Abnormalities

Project: Types of projects

  • Gerstoft, Jan, The Capital Region of Denmark Rigshospitalet, Denmark (Project participant)
  • Hansen, Ann-Britt E, Odense University Hospital, Denmark (Project participant)
  • Pedersen, Court, Odense University Hospital, Denmark (Project participant)
  • Mathiesen, Lars Reinhardt (Project participant)
  • Laursen, Alex, Aarhus University Hospital, Denmark (Project participant)
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Highly active antiretroviral therapy (HAART) has improved the long time survival of HIV infected individuals. However an increasing number of HIV-patients have developed metabolic and morphological alterations including peripheral lipoatrophy. The main hypothesis of the study is that switching from thymidine-analogue based HAART will reverse lipoatrophy. We plan to perform an observational study recruiting up to 100 HIV-infected patients receiving Trizivir (zidovudine/lamivudine/abacavir). The patients will be offered an NRTI or lopinavir/ritonavir instead of zidovudine or they can choose to continue with Trizivir. The main endpoint is changes in peripheral fat mass as determined by DEXA-scanning.
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ID: 32505851