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The Capital Region of Denmark - a part of Copenhagen University Hospital

Short-term versus long-term mentalization-based treatment for outpatients with subthreshold or diagnosed borderline personality disorder: a randomized clinical trial

Project: Types of projects

  • Simonsen, Sebastian (Project Manager, academic)
  • Juul , Sophie (Project Coordinator)
  • Jakobsen, Janus Christian (Project participant)
  • Lunn, Susanne , Institut for Psykologi, Københavns Universitet , Denmark (Project participant)
  • Poulsen, Stig , Institut for Psykologi, Københavns Universitet , Denmark (Project participant)
  • Sørensen, Per (Project Manager, organisational)
  • Bateman, Anthony , St. Anns Hospital, London, UK , Unknown (Project participant)
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Baggrund
Psychotherapy for borderline personality disorder is often lengthy and resource-intensive. However, the current length of outpatient treatments is arbitrary and based on trials, which never tested if the treatment intensity could be reduced. As a result, there is insufficient evidence to inform the decision between short-term and long-term psychotherapy for borderline personality disorder. Mentalization-based therapy is one treatment option for borderline personality disorder and consists traditionally of an 18-months treatment program.

Formål
The primary objective of this trial will be to evaluate the beneficial and harmful effects of short-term (20 weeks) mentalization-based therapy compared with long-term (14 months) mentalization-based therapy for adult outpatients with subthreshold or diagnosed borderline personality disorder.

Design
This trial is an investigator-initiated, single-centre, randomized clinical superiority trial of short-term (20 weeks) compared to long-term (14 months) mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder. Participants will be recruited from the Outpatient Clinic for Personality Disorders at Stolpegaard Psychotherapy Centre, Mental Health Services, Capital Region of Denmark. Participants will be included if they meet a minimum of four DSM-V criteria for borderline personality disorder. Participants will be assessed before randomization, and at 8, 16, and 24 months after randomization. The primary outcome is severity of borderline symptomatology assessed with the Zanarini Rating Scale for Borderline Personality Disorder. Secondary outcomes include self-harm incidents, functional impairment (Work and Social Adjustment Scale, Global Assessment of Functioning) and quality of life (Short-Form Health Survey 36). Severity of psychiatric symptoms (Symptom Checklist-90-R) will be included as an exploratory outcome. Measures of personality functioning, attachment, borderline symptoms, group alliance and mentalization skills will be included to explore potential predictors and mechanisms of change. We will include a total of 166 participants.
StatusCurrent
Period19/09/201801/06/2023
Financing sourceOther private funding (private)
Research programmeShort-tern versus long-term
Amount2,585,799.00 Danish Kroner
Approval year2018
Financing sourceInternal funding (public)
Research programmeshort-term versus long-term
Amount1,596,000.00 Danish Kroner
Approval year2018

    Research areas

  • Health Sciences - Personality Disorders, Psychotherapy, Randomized Controlled Clinical Trial

ID: 56510410