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The Capital Region of Denmark - a part of Copenhagen University Hospital

Developmental effects of environment on reproduction

Project: Types of projects

  • Andersson, Anna-Maria (Project participant)
  • Skakkebæk, Niels Erik (Project participant)
  • Juul, Anders (Project participant)
  • Main, Katharina Maria (Project participant)
  • Jørgensen, Niels (Project participant)
  • Rajpert-De Meyts, Ewa (Project participant)
  • Toppari, Jorma (Project participant)
  • Sharpe, Richard, MRC, Edinburgh, United Kingdom (Project participant)
  • Tena-Sempere, Manuel, University of Cordoba, Spain (Project participant)
  • Jegou, Bernard, University of Rennes 1, France (Project participant)
  • Atanassova, Nina, Bulgarian Academy of Sciences (IEMAM), Bulgaria (Project participant)
  • Le Bizec, Bruno, Ecole Nationale Vétrinaire de Nantes, France (Project participant)
  • Brunak, Søren, Denmark (Project participant)
  • Swan, Shanna, United States (Project participant)
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DEER is a multidisciplinary research project aiming at improving our understanding of the role of environmental factors in the development and establishment of human reproductive health.
It is widely accepted that fetal events can predispose an individual to develop certain health disorders in adulthood; indeed, the commonest disorders of European and Western adults today (obesity, type 2 diabetes, cardiovascular disease), which are increasing progressively in incidence, are well-established to have prenatal determinants.
Equally, it is increasingly clear that the commonest disorders of male reproductive health in newborn (cryptorchidism, hypospadias) and young adult (low sperm counts, testis germ cell cancer) human males may also be caused by adverse events in fetal (and perhaps neonatal) life. These reproductive disorders are thought to comprise a testicular dysgenesis syndrome (TDS), which arises because of a cascade of changes triggered by maldevelopment and malfunction of the fetal testis. The incidence of TDS disorders appears to be increasing in Europe.
StatusCompleted
Period01/05/200831/03/2012

ID: 46257092