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The Capital Region of Denmark - a part of Copenhagen University Hospital

Predicting effects and risk of relapse into depression - the Danish ECT/MRI project

Project: Types of projects

  1. ELECTROCONVULSIVE THERAPY INCREASES BRAIN VOLUME IN DEPRESSION

    Research output: Contribution to conferencePosterResearch

  2. Predicting effects and risk of relapse into depression: The Danish ECT/MRI project

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  3. Electroconvulsive therapy increases brain volume in major depression: a systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  4. Cortical thickness following electroconvulsive therapy in patients with depression - a longitudinal MRI study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Electroconvulsive therapy increases cortical thickness in depression

    Research output: Contribution to conferencePosterResearch

  6. Electroconvulsive therapy increases cortical thickness in depression

    Research output: Contribution to conferencePosterResearch

  7. Volume of hippocampal subregions and clinical improvement following electroconvulsive therapy in patients with depression

    Research output: Contribution to journalJournal articleResearchpeer-review

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By using the most modern MR techniques, this project aims firstly at examining the mechanisms behind electroconvulsive therapy (ECT), including finding predictors for a favourable result; early relapse as well as for side effects. Secondly, we wish to examine any possible structural changes in the brain after the ECT indicating both mechanism of actions and possible damage to brain tissue. Finally, we wish to examine the magnitude of the often reported adverse effect on the subjective memory function of the patients.
The study comprises 60 patients from Mental Health Centres Glostrup, Amager and Copenhagen who are scheduled for ECT because of severe depression. MRI is performed using an advanced protocol before and after a series of ECT. Apart from conventional structural imaging, VBM, DTI, and fibre tracking will be performed. Furthermore, these examinations will be repeated after 6 months to look for any possible long-term effects. Furthermore, adverse effects especially regarding subjective memory complaints will be held up against the information from structural and functional imaging.
StatusCurrent
Period01/10/201630/09/2020
Financing sourcePrivate funding (private)
Research programmeBeckett Fonden
Amount150,000.00 Danish Kroner
Approval year2015
Financing sourcePrivate funding (private)
Research programmeLundbeck Fonden
Amount1,875,000.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmeLundbeck Fonden
Amount462,340.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmeIvan Nilsens Fond
Amount25,000.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmeAxel Muusfeldts Fond
Amount150,000.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmeHelsefonden
Amount400,000.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmeAugustinus Fonden
Amount300,000.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmePsykiatrisk Forskningsfond af 1967
Amount50,000.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmeLæge Gerhard Lind Legat
Amount70,000.00 Danish Kroner
Approval year2016
Financing sourceOther public support (public)
Research programmeRegion Hovedstaden Psykiatris Forskningsfond
Amount60,000.00 Danish Kroner
Approval year2018
Financing sourcePrivate funding (private)
Research programmeA.P. Møller: Fonden til Lægevidenskabens fremme
Amount95,000.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmeJascha Fonden
Amount400,000.00 Danish Kroner
Approval year2016
Financing sourcePrivate funding (private)
Research programmeIvan Nilsens Fond
Amount125,000.00 Danish Kroner
Approval year2018

    Research areas

  • Health Sciences - Mood Disorders, Neuroimaging, Observational study

ID: 49220426