By using the most modern MR techniques, this project aims firstly at examining the mechanisms behind electroconvulsive therapy (ECT), including finding predictors for a favourable result; early relapse as well as for side effects. Secondly, we wish to examine any possible structural changes in the brain after the ECT indicating both mechanism of actions and possible damage to brain tissue. Finally, we wish to examine the magnitude of the often reported adverse effect on the subjective memory function of the patients.
The study comprises 60 patients from Mental Health Centres Glostrup, Amager and Copenhagen who are scheduled for ECT because of severe depression. MRI is performed using an advanced protocol before and after a series of ECT. Apart from conventional structural imaging, VBM, DTI, and fibre tracking will be performed. Furthermore, these examinations will be repeated after 6 months to look for any possible long-term effects. Furthermore, adverse effects especially regarding subjective memory complaints will be held up against the information from structural and functional imaging.