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The Capital Region of Denmark - a part of Copenhagen University Hospital

CO-HEP; Copenhagen Hepatitis C Program

Project: Types of projects

  1. Differential Sensitivity of 5'UTR-NS5A Recombinants of Hepatitis C Virus Genotypes 1-6 to Protease and NS5A Inhibitors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Expanded classification of hepatitis C Virus into 7 genotypes and 67 Subtypes: updated criteria and assignment web resource

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Analysis of hepatitis C virus Core/NS5A co-localization using novel cell culture systems expressing Core-NS2 and NS5A of genotype 1-7

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Persistent human hepatitis B virus infection in cynomolgus monkeys: A novel animal model in the search for a cure?

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Identification of a pegivirus (GB virus-like virus) that infects horses

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Are variations in whole blood BDNF level associated with the BDNF Val66Met polymorphism in patients with first episode depression?

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. The effect of prolonged duration of untreated depression on antidepressant treatment outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Identification of rodent homologs of hepatitis C virus and pegiviruses

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Productive Homologous and Non-homologous Recombination of Hepatitis C Virus in Cell Culture

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Combination treatment with HCV protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a and 3a virus

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Analysis of Functional Differences between Hepatitis C Virus NS5A of Genotypes 1-7 in Infectious Cell Culture Systems

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Animal models for the study of hepatitis C virus infection and related liver disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8⁺ T cells in early viral evolution

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Hepatitis C homolog in dogs with respiratory illness

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Recombinant HCV Variants With NS5A From Genotypes 1-7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-α

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. FLAVIVIRIDAE

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  29. Determining the frequency and mechanisms of HIV-1 and HIV-2 RNA copackaging by single-virion analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Mechanisms and factors that influence high frequency retroviral recombination

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Multiple barriers to recombination between divergent HIV-1 variants revealed by a dual-marker recombination assay

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Molecular and epidemiological profiles of hepatitis C virus genotype 4 in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

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Globally 180 million people are infected with hepatitis C virus, which causes chronic liver diseases. A newly developed type of therapy shows very promising results but the disease has a tendency to mutate and thereby avoid the effect of the drugs. This project will map the mutation patterns and explore the possibility for individually tailored treatment of hepatitis C.

Hepatitis C is a chronic liver infection, which can lead to iver cirrhosis and liver cancer. Until now the infection has been very difficult to treat - and the treatment has often had several serious unwanted side-effects.

Recently a new type of drug that targets the virus directly has been developed and this medicine has been shown to improve treatment results when combined with the current treatment. Long term these new drugs, perhaps given as combination therapy with drugs targeting different viral functions, could contribute to saving the lives of a great number of patients. Unfortunately, the virus has an incredible ability to mutate and thereby avoid the effect of the newly developed drugs.

Mapping resistance

This project will investigate how the new medication works on the various types of hepatitis C virus, and it will map the different viral mutations that are resulting in resistance.

These findings will benefit the patients by ensuring that the drugs used have an optimal effect against the patients virus isolate or . Furthermore, this new information on drug effectiveness and the patterns of resistance will be collected in a database which can in turn be used to prepare a tailored treatment plan for the individual patient who is infected with hepatitis C.

In Denmark there are around 15,000 people infected by hepatitis C virus
StatusCompleted
Period01/01/2006 → …

ID: 42204532