Personal profile
Expertises
Translational research; cancer; anticancer drugs; cell culture; molecular biology
Main research areas
non-melanoma skin cancer; laser-assisted drug delivery; topical drug delivery; advanced imaging systems
Current research
Currently, we are exploring the use of ablative fractional laser to facilitate localised, topical treatment with systemic anticancer drugs. This allows for more efficient treatment of skin cancer with reduced side-effects. Specifically, we aim to use the very promising systemically applied drugs, hedgehog inhibitors, for localised treatment of basal cell carcinomas, the most common cancer in humans. The project combines preclinical and clinical research, which is conducted in collaboration with the Technical University of Denmark, Harvard Medical School and University of Copenhagen. The research effort is supported by The Danish Council for Independent Research - Medical Sciences and The Research Foundation for Healthcare Research of the Capital Region of Denmark.
"Potential conflicts of interest
No potential COI.
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Collaborations and top research areas from the last five years
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Cutaneous Immune Responses to Ablative Fractional Laser, Heat- and Cold-Based Dermatological Procedures
Christensen, R. L., Son, H. G., Zhou, E. Y., Olesen, U. H., Garibyan, L., Farinelli, W. A., Sakamoto, F. H., Rox Anderson, R., Haedersdal, M. & Demehri, S., Jan 2025, In: Lasers in Surgery and Medicine. 57, 1, p. 101-111 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Intratumoral sustained release of resiquimod with ablative fractional laser induces efficacy in a cutaneous squamous cell carcinoma mouse model
Wiinberg, M., Melander, F., Lerche, C. M., Andresen, T. L., Olesen, U. H. & Haedersdal, M., 2025, In: Frontiers in Immunology. 16, 1625867.Research output: Contribution to journal › Journal article › Research › peer-review
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Oral nicotinamide mononucleotide (NMN) increases tissue NAD+ content in mice but neither NMN nor Polypodium leucotomos protect against UVR-induced skin cancer
Pihl, C., Kara, R. D., Granborg, J. R., Olesen, U. H., Bjerring, P., Haedersdal, M., Untracht, G. R. & Lerche, C. M., Jun 2025, In: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 24, 6, p. 1069-1078 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus) -
Ablative fractional CO2 laser treatment promotes wound healing phenotype in skin macrophages
Wiinberg, M., Andresen, T. L., Haedersdal, M. & Olesen, U. H., Mar 2024, In: Lasers in Surgery and Medicine. 56, 3, p. 270-278 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
Ablative fractional laser treatment reduces hedgehog pathway gene expression in murine basal cell carcinomas
Pedersen, K. K., Granborg, J. R., Lerche, C. M., Litman, T., Olesen, U. H. & Hædersdal, M., 3 Feb 2024, In: Lasers in Medical Science. 39, 1, p. 55Research output: Contribution to journal › Journal article › Research › peer-review
2 Citations (Scopus)