Research output per year
Research output per year
Personal profile
Expertises
Translational research; cancer; anticancer drugs; cell culture; molecular biology
Main research areas
non-melanoma skin cancer; laser-assisted drug delivery; topical drug delivery; advanced imaging systems
Current research
Currently, we are exploring the use of ablative fractional laser to facilitate localised, topical treatment with systemic anticancer drugs. This allows for more efficient treatment of skin cancer with reduced side-effects. Specifically, we aim to use the very promising systemically applied drugs, hedgehog inhibitors, for localised treatment of basal cell carcinomas, the most common cancer in humans. The project combines preclinical and clinical research, which is conducted in collaboration with the Technical University of Denmark, Harvard Medical School and University of Copenhagen. The research effort is supported by The Danish Council for Independent Research - Medical Sciences and The Research Foundation for Healthcare Research of the Capital Region of Denmark.
"Potential conflicts of interest
No potential COI.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Laser-assisted topical delivery of vismodegib reduces hedgehog gene expression in human basal cell carcinomas in vivo
Olesen, U. H., Pedersen, K. K., Togsverd-Bo, K., Biskup, E., Nielsen, A. L., Jackerott, M., Clergeaud, G., Andresen, T. L. & Haedersdal, M., Mar 2024, In: Lasers in Surgery and Medicine. 56, 3, p. 239-248 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Repeated exposure to fractional CO2 laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line-field confocal optical coherence tomography and histology
Olesen, U. H., Jacobsen, K., Lerche, C. M. & Haedersdal, M., Jan 2023, In: Lasers in Surgery and Medicine. 55, 1, p. 73-81 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Feasibility of Intratumoral Anti-PD1 as Treatment of Human Basal Cell Carcinoma: An Explorative Study with Adjuvant Ablative Fractional Laser
Omland, S. H., Ejlertsen, J. S., Krustrup, D., Christensen, R. L., Svane, I. M., Olesen, U. H. & Hædersdal, M., 25 Nov 2022, In: Cancers. 14, 23, 5815.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry
Bik, L., van Doorn, M., Hansen, A. C. N., Janfelt, C., Olesen, U. H., Haedersdal, M., Lerche, C. M. & Hendel, K., Feb 2022, In: Expert Opinion on Drug Delivery. 19, 2, p. 213-219 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Optical Imaging Visualizes a Homogeneous and Horizontal Band-Like Biodistribution of Large- and Small-Size Hydrophilic Compounds Delivered by Ablative Fractional Laser
Christensen, R. L., Ortner, V. K., Haedersdal, M. & Olesen, U. H., 23 Jul 2022, In: Pharmaceutics. 14, 8, 1537.Research output: Contribution to journal › Journal article › Research › peer-review