Research output per year
Research output per year
Personal profile
Main research areas
My principal research interests lie in the field of cell and molecular biology of the insulin-producing β-cells. My key areas of expertise are in vitro and ex vivo models of β-cell dysfunction and apoptosis in relation to type 1 diabetes. My research focuses on understanding the role of the type 1 diabetes candidates genes in relation to β-cell function and type 1 diabetes development.
Current research
My current research focuses on unraveling the functions of the cathepsin protease family in the β-cells and their potential involvement in the pathogenesis of type 1 diabetes.
Expertises
Expert in culture of mammalian cell lines and primary tissue, isolation of mouse pancreatic islets, transient and stable transfection, viability and apoptosis assays, ELISA, extraction of RNA/protein/DNA, real-time qPCR, genotyping, western blotting and gel electrophoresis. Experienced in tissue harvesting, immunohistochemistry, immunocytochemistry and transmission electron microscopy.
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Collaborations and top research areas from the last five years
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Research output
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beta Cell and Autophagy: What Do We Know? What Do We Know?
Mohammadi-Motlagh, H-R., Sadeghalvad, M., Yavari, N., Primavera, R., Soltani, S., Chetty, S., Ganguly, A., Regmi, S., Fløyel, T., Kaur, S., Mirza, A. H., Thakor, A. S., Pociot, F. & Yarani, R., 4 Apr 2023, In: Biomolecules. 13, 4, 649.Research output: Contribution to journal › Review › peer-review
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Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
Frørup, C., Gerwig, R., Svane, C. A. S., Mendes Lopes de Melo, J., Henriksen, K., Fløyel, T., Pociot, F., Kaur, S. & Størling, J., 2023, In: Frontiers in Endocrinology. 14, p. 1128523 1128523.Research output: Contribution to journal › Journal article › Research › peer-review
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Editorial: The gut-pancreas axis in type 1 diabetes - a focus on environmental factors
Fløyel, T., Funda, D., Dodero, V. I. & Haupt-Jorgensen, M., 2023, In: Frontiers in Endocrinology. 14, p. 1270297 1270297.Research output: Contribution to journal › Editorial › peer-review
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Characterisation of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
Frørup, C., Gerwig, R., Svane, C. A. S., Mendes Lopes de Melo, J., Fløyel, T., Pociot, F., Kaur, S. & Størling, J., 2022, (Submitted) In: bioRxiv.Research output: Contribution to journal › Journal article › Research
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Oral administration of the small molecule cathepsin S inhibitor LY3000328 accelerates disease onset and impairs glucose tolerance in non-obese diabetic mice
Fløyel, T., Frørup, C., Haupt-Jorgensen, M., Holm, L. J., Pedersen, K., Mønsted, M. Ø., Buschard, K. S., Størling, J. & Pociot, F., 31 Aug 2022, In: Diabetologia. 65, SUPPL 1, p. S109-S110 1 p., 210.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review