Research output per year
Research output per year
Personal profile
Expertises
In vitro and in vivo studies of bacterial and fungal biofilms
Confocal and electron microscopy
Main research areas
The role of bacterial and fungal biofilms in chronic infections
Current research
We study the role of bacterial and fungal biofilms in chronic infections both in vitro, animal models and ex vivo material from chronic infections. Our interests are how bacteria initiate biofilms in the human body and why the immune defense seems to fail both in the initial infection and later in the chronic infection. What is the prevalence of bacteria and fungus on implants in general? What is the activity of the microbes in chronic infections and which species are present? We also seek to develop tools and methods to enable fast diagnosis of these infections, for better treatment and possible prevention.
Potential conflicts of interest
None
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Research output
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3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism
Adams, Y., Clausen, A. S., Jensen, P. Ø., Lager, M., Wilhelmsson, P., Henningson, A. J., Lindgren, P-E., Faurholt-Jepsen, D., Mens, H., Kraiczy, P., Kragh, K. N., Bjarnsholt, T., Kjaer, A., Lebech, A-M. & Jensen, A. R., 20 Jan 2023, In: iScience. 26, 1, p. 105838 105838.Research output: Contribution to journal › Journal article › Research › peer-review
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Adaptation of Pseudomonas aeruginosa biofilms to tobramycin and the quorum sensing inhibitor C-30 during experimental evolution requires multiple genotypic and phenotypic changes
Bové, M., Kolpen, M., Lichtenberg, M., Bjarnsholt, T. & Coenye, T., Jan 2023, In: Microbiology (Reading, England). 169, 1, 001278.Research output: Contribution to journal › Journal article › Research › peer-review
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Defining the temporal relationship between the skin microbiome, immune response and skin barrier function during flare and resolution of atopic dermatitis: protocol of a Danish intervention study
Rønnstad, A. T. M., Bay, L., Ruge, I. F., Halling, A-S., Fritz, B. G., Jakaša, I., Luiten, R., Kezic, S., Thomsen, S. F., Bjarnsholt, T. & Thyssen, J. P., 17 Feb 2023, In: BMJ Open. 13, 2, e068395.Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol to assess metabolic activity of Pseudomonas aeruginosa by measuring heat flow using isothermal calorimetry
Beilharz, K., Kragh, K. N., Fritz, B., Kirkegaard, J. B., Tolker-Nielsen, T., Bjarnsholt, T. & Lichtenberg, M., 1 May 2023, (E-pub ahead of print) In: STAR Protocols. 4, 2, p. 102269 102269.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas
Høiby, N., Bjarnsholt, T. & Ciofu, O., 27 Jun 2023, Manual of Clinical Microbiology. Carroll, K. C., Pfaller, M. A., Karlowsky, J. A., Landry, M. L., McAdam, A. J., Patel, R. & Pritt, B. S. (eds.). 13 ed. ASM PublishingResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Activities
- 14 Lecture and oral contribution
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Når bakterier klumper sammen
Thomas Bjarnsholt (Lecturer)
10 Dec 2010Activity: Talk or presentation › Lecture and oral contribution
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Once bacteria aggregate
Thomas Bjarnsholt (Lecturer)
9 Nov 2010Activity: Talk or presentation › Lecture and oral contribution
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Danmarks Mikrobiologiske Selskabs årlige symposium
Thomas Bjarnsholt (Speaker)
9 Nov 2010Activity: Talk or presentation › Lecture and oral contribution
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Magister foreningens symposium om nye teknikker til bakterielle undersøgelser
Thomas Bjarnsholt (Speaker)
27 Oct 2010Activity: Talk or presentation › Lecture and oral contribution
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Biofilm 4
Thomas Bjarnsholt (Speaker)
21 Oct 2010 → 23 Oct 2010Activity: Talk or presentation › Lecture and oral contribution