Research output per year
Research output per year
Personal profile
Expertises
I have a comprehensive knowledge about the theoretical and practical aspects of ovarian tissue cryopreservation, and have performed the procedure since 2009 at LRB. I have specialized in human reproductive biology including ovarian pathology and fertility preservation, and my work focuses on human follicle development and the regulatory mechanisms underlying early folliculogenesis.
Í'm is also course-coordinator of The Copenhagen Workshop on Cryopreservation of Ovarian Tissue and chair of ReproYoung (association of young researcher in ReproUnion).
"Main research areas
Reproductive biology; fertility preservation; ovarian tissue cryopreservation; ovarian physiology; endocrinolgy; folliculogenesis; 3D culture systems for isolated preantral follicles; the transforming growth factor beta signaling pathway.
Current research
Evaluating the effect of androgens on human preantral follicle growth, and the importance of the TGF-beta signaling pathway in ovaries from women with PCOS.
Improving the revascularization and grafting of thawed human ovarian tissue using various antioxidants.
Creating an artificial ovary by decellularizing ovarian tissue and regrafting with ovarian cells.
Characterising expression profiles in human follicles.
Culturing isolated preantral follicles in a 3D alginate hydrogel.
Developing new methods for quantifying follicular survival after freezing.
Testing different cryoprotectants and media-supplements for transport and freezing of ovarian tissue.
"Potential conflicts of interest
none
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Collaborations and top research areas from the last five years
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Comment on 'Atlas of Fshr expression from novel reporter mice'
Casarini, L., Rahman, N., Reiter, E., Crépieux, P., Rivero-Müller, A., Jonas, K. C., Kumar, T. R., Ulloa-Aguirre, A., Franks, S., Bernard, D. J., Kristensen, S. G., Davis, J. S., Bousfield, G. R., Dias, J. A., Andersen, C. Y., Handelsman, D. J., Huhtaniemi, I. T. & Simoni, M., 24 Mar 2025, In: Endocrinology. 166, 5, bqaf066.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct Luteinization Profiles of Cultured Human Granulosa Cells from Small Antral and Preovulatory Follicles
Jensen, L. B., Adrados, C. S., Bøtkjær, J. A., Cadenas, J., Sittadjody, S., Opara, E., Sørensen, P. L., Macklon, K. T., Pedersen, A. T. & Kristensen, S. G., 5 Apr 2025, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
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Follicular fluid concentrations of the vitamin D metabolite 24,25(OH)2D3 are positively associated with live birth rate after assisted reproductive technology
Kooij, I., Holt, R., Juel Mortensen, L., Lorenzen, M., Bentin-Ley, U., Krog, H., Hayden Berg, A., Juul, A., Kristensen, S. G., Jørgensen, A. & Blomberg Jensen, M., Jun 2025, In: The Journal of steroid biochemistry and molecular biology. 251, p. 106764 106764.Research output: Contribution to journal › Journal article › Research › peer-review
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Human ovarian tissue xenotransplantation: advancements, challenges, and future perspectives
Thuwanut, P., Leonel, E. C. R., Rocha Ruiz, T. F., Sirayapiwat, P., Kristensen, S. G. & Amorim, C. A., 1 Mar 2025, In: Human Reproduction. 40, 3, p. 410-419 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of female age on concentrations of reproductive hormones and oocyte-specific growth factors in follicular fluid from human small antral follicles
Wang, N. F., Mamsen, L. S., Cadenas, J., Saritas, G., Macklon, K. T., Fedder, J., Ernst, E., Johannsen, M. L., Kristensen, S. G., Kelsey, T., Kumar, A., Kalra, B., Løssl, K. & Andersen, C. Y., 1 Apr 2025, In: Human Reproduction. 40, 4, p. 707-716 10 p.Research output: Contribution to journal › Journal article › Research › peer-review