Steen Hasselbalch

2011

Cerebral serotonin 4 receptors and amyloid-β in early Alzheimer's disease

Madsen, K., Neumann, W.-J., Holst, K., Marner, L., Haahr, M. T., Lehel, S., Knudsen, G. M. & Hasselbalch, S. G., 2011, In: Journal of Alzheimer's Disease. 26, 3, p. 457-66 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

66 Citations (Scopus)

Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects

Madsen, K., Erritzøe, D., Mortensen, E. L., Gade, A., Madsen, J., Baaré, W. F. C., Knudsen, G. M. & Hasselbalch, S. G., 1 Feb 2011, In: Psychopharmacology. 213, 2-3, p. 573-81 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

The Reduction of Baseline Serotonin 2A Receptors in Mild Cognitive Impairment is Stable at Two-year Follow-up

Marner, L., Knudsen, G. M., Madsen, K., Holm, S., Baaré, W. F. C. & Hasselbalch, S. G., 1 Jan 2011, In: Journal of Alzheimer's disease : JAD. 23, 3, p. 453-9 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

2010

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial

Vandenberghe, R., Van Laere, K., Ivanoiu, A., Salmon, E., Bastin, C., Triau, E., Hasselbalch, S., Law, I., Andersen, A., Kørner, E. A., Minthon, L., Garraux, G., Nelissen, N., Bormans, G., Buckley, C., Owenius, R., Thurfjell, L., Farrar, G. & Brooks, D. J., 2010, In: Annals of Neurology. 68, 3, p. 319-29 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

588 Citations (Scopus)

Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET

Marner, L., Gillings, N., Madsen, K., Erritzøe, D., Baaré, W. F. C., Svarer, C., Hasselbalch, S. G. & Knudsen, G. M., 15 Apr 2010, In: NeuroImage. 50, 3, p. 855-61 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

72 Citations (Scopus)

Cerebral blood flow response to functional activation

Paulson, O. B., Hasselbalch, S. G., Rostrup, E., Knudsen, G. M. & Pelligrino, D., 1 Jan 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 1, p. 2-14 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

192 Citations (Scopus)

Cocaine is pharmacologically active in the nonhuman primate fetal brain

Benveniste, H., Fowler, J. S., Rooney, W. D., Scharf, B. A., Backus, W. W., Izrailtyan, I., Knudsen, G. M., Hasselbalch, S. G. & Volkow, N. D., 26 Jan 2010, In: National Academy of Sciences. Proceedings. 107, 4, p. 1582-7 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

Lewy body-demens

Translated title of the contribution: Lewy body dementiaZiebell, M., Korbo, L. & Hasselbalch, S. G., 31 May 2010, In: Ugeskrift for Laeger. 172, 22, p. 1675-8 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

Feldman, H. H., Doody, R. S., Kivipelto, M., Sparks, D. L., Waters, D. D., Jones, R. W., Schwam, E., Schindler, R., Hey-Hadavi, J., DeMicco, D. A., Breazna, A., LEADe investigators & Hasselbalch, S. G. (Member of study group), 23 Mar 2010, In: Neurology. 74, 12, p. 956-64 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2009

A Probabilistic Approach to Delineating Functional Brain Regions

Kalbitzer, J., Svarer, C., Frokjaer, V. G., Erritzoe, D., Baaré, W. F. C., Madsen, J., Hasselbalch, S. G. & Knudsen, G. M., 2009, In: Journal of Nuclear Medicine Technology. 37, 2, p. 91-95 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Behandling af demenssygdomme--hvem skal behandles?

Translated title of the contribution: Treatment of degenerative dementia disorders--who should be treated?Hasselbalch, S. G. & Kampmann, J. P., 2 Mar 2009, In: Ugeskrift for Laeger. 171, 10, p. 802-5 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Kinetic Modeling of 11C-SB207145 Binding to 5-HT4 Receptors in the Human Brain In Vivo

Marner, L., Gillings, N., Comley, R. A., Baaré, W. F. C., Rabiner, E. A., Wilson, A. A., Houle, S., Hasselbalch, S. G., Svarer, C., Gunn, R. N., Laruelle, M. & Knudsen, G. M., 2009, In: Journal of Nuclear Medicine. 50, 6, p. 900-908 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

79 Citations (Scopus)

2008

Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder

Frokjaer, V. G., Mortensen, E. L., Nielsen, F. A., Haugbol, S., Pinborg, L. H., Adams, K. H., Svarer, C., Hasselbalch, S. G., Holm, S., Paulson, O. B. & Knudsen, G. M., 2008, In: Biological Psychiatry. 63, 6, p. 569-76 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

163 Citations (Scopus)

Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study

Marner, L., Knudsen, G. M., Haugbøl, S., Holm, S., Baaré, W. & Hasselbalch, S. G., 2008, In: European Journal of Nuclear Medicine and Molecular Imaging. 36, 2, p. 287-93 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Reduced 5-HT2A receptor binding in patients with mild cognitive impairment

Hasselbalch, S., Madsen, K., Svarer, C., Pinborg, L. H., Holm, S., Paulson, O. B., Waldemar, G. & Knudsen, G. M., 2008, In: Neurobiology of Aging. 29, 12, p. 1830-8 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

106 Citations (Scopus)

The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics

Jones, R. W., Kivipelto, M., Feldman, H., Sparks, L., Doody, R., Waters, D. D., Hey-Hadavi, J., Breazna, A., Schindler, R. J., Ramos, H., LEADe investigators & Hasselbalch, S. G. (Member of study group), Mar 2008, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 4, 2, p. 145-53 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The hemodynamic response during functional activation reflects coupling rather than uncoupling

Paulson, O. B., Moos Knudsen, G., Hasselbalch, S. G. & Rostrup, E., 2008.

Research output: Contribution to conference › Poster › Research

The hemodynamic response during functional activation reflects coupling rather than uncoupling

Haugbol, S., Pinborg, L. H., Frøkjær, V. G., Erritzø, D., Marner, L., Hasselbalch, S. G., Svarer, C., Hasholt, L., Holm, S., Paulson, O. B. & Moos Knudsen, G., 2008.

Research output: Contribution to conference › Poster › Research › peer-review

The personality trait openness is related to cerebral 5-HTT levels

Kalbitzer, J., Frokjaer, V. G., Erritzoe, D., Svarer, C., Cumming, P., Nielsen, F. A., Hashemi, S. H., Baaré, W. F. C., Madsen, J., Hasselbalch, S. G., Kringelbach, M. L., Mortensen, E. L. & Knudsen, G. M., 2008, In: NeuroImage. 45, 2, p. 280-5 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

82 Citations (Scopus)

2007

Education and training of European neurologists in dementia

Hasselbalch, S. G., Baloyannis, S., Denislic, M., Dubois, B., Oertel, W., Rossor, M., Tsiskaridze, A. & Waldemar, G., May 2007, In: European Journal of Neurology. 14, 5, p. 505-9 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Reduced midbrain-pons serotonin transporter binding in patients with obsessive-compulsive disorder

Hasselbalch, S. G., Hansen, E. S., Jakobsen, T. B., Pinborg, L. H., Lønborg, J. H. & Bolwig, T. G., May 2007, In: Acta Psychiatrica Scandinavica. 115, 5, p. 388-94 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Visual rating and ROI-based parametric analysis of rCBF SPECT in patients with mild or questionable dementia: a comparative study

Høgh, P., Teller, A.-S., Hasselbalch, S. & Waldemar, G., 2007, In: Dementia and Geriatric Cognitive Disorders. 24, 6, p. 429-33 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2006

Billeddiagnostik ved demensudredning

Translated title of the contribution: Diagnostic imaging in dementia evaluationHasselbalch, S. G., Gyldensted, C., Sørensen, L. H., Braendgaard, H., Andersen, K., Lolk, A., Kragh-Sørensen, P. & Waldemar, G., 2 Oct 2006, In: Ugeskrift for Laeger. 168, 40, p. 3415-9 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat

Linde, R., Hasselbalch, S. G., Topp, S., Paulson, O. B. & Madsen, P. L., 2006, In: Journal of Cerebral Blood Flow and Metabolism. 26, 2, p. 170-180

Research output: Contribution to journal › Journal article › Research › peer-review

Longitudinal assessment of cerebral 5-HT2A receptors in normal volunteers. An [18F]-altanserin PET study

Marner, L., Knudsen, G. M., Madsen, K., Haugbøl, S., Vogel, A., Holm, S., Baaré, W. F. C. & Hasselbalch, S. G., 2006. 1 p.

Research output: Contribution to conference › Poster › Research

Patient versus informant reported quality of life in the earliest phases of Alzheimer's disease

Vogel, A., Mortensen, E. L., Hasselbalch, S. G., Andersen, B. B. & Waldemar, G., 2006, In: International Journal of Geriatric Psychiatry. 21, 12, p. 1132-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

129 Citations (Scopus)

2005

Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease

Vogel, A., Hasselbalch, S. G., Gade, A., Ziebell, M. & Waldemar, G., 1 Mar 2005, In: International Journal of Geriatric Psychiatry. 20, 3, p. 238-46 9 p.

Research output: Contribution to journal › Journal article › Research

150 Citations (Scopus)

MR-based automatic delineation of volumes of interest in human brain PET images using probability maps.

Svarer, C., Madsen, K., Hasselbalch, S. G., Pinborg, L. H., Haugbøl, S., Frøkjær, V. G., Holm, S., Paulson, O. B. & Knudsen, G. M., 2005, In: NeuroImage. 24, 4, p. 969-979

Research output: Contribution to journal › Journal article › Research › peer-review

309 Citations (Scopus)

Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei

Adams, K. H., Hansen, E. S., Pinborg, L. H., Hasselbalch, S. G., Svarer, C., Holm, S., Bolwig, T. G. & Knudsen, G. M., Sept 2005, In: International Journal of Neuropsychopharmacology. 8, 3, p. 391-401 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2004

[18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge.

Pinborg, L. H., Adams, K. H., Yndsgaard, S., Hasselbalch, S. G., Holm, S., Kristiansen, H., Paulson, O. B. & Knudsen, G. M., 2004, In: Journal of Cerebral Blood Flow and Metabolism. 24, 9, p. 1037-1045

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables

Adams, K. H., Pinborg, L. H., Svarer, C., Hasselbalch, S. G., Holm, S., Haugbøl, S., Madsen, K., Frøkjaer, V., Martiny, L., Paulson, O. B. & Knudsen, G. M., 2004, In: NeuroImage. 21, 3, p. 1105-13 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

112 Citations (Scopus)

Er medicinsk Alzheimerbehandling uden virkning?

Translated title of the contribution: Is drug therapy of Alzheimer disease ineffective?Johannsen, P., Abelskov, K. E., Almar, K., Christensen, P. H., Hasselbalch, S. G., Laugesen, L. P., Hansen, F. R. & Skausig, O. B., 16 Aug 2004, In: Ugeskrift for Laeger. 166, 34, p. 2916-8 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mosaicism of the CAG repeat sequence in the Huntington disease gene in a pair of monozygotic twins

Nørremølle, A., Hasholt, L., Petersen, C. B., Eiberg, H., Hasselbalch, S. G., Gideon, P., Nielsen, J. E. & Sørensen, S. A., 1 Oct 2004, In: American Journal of Medical Genetics. Part A. 130A, 2, p. 154-9 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2003

Quantification of 5-HT2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach

Pinborg, L. H., Adams, K. H., Svarer, C., Holm, S., Hasselbalch, S. G., Haugbøl, S., Madsen, J. & Knudsen, G. M., Aug 2003, In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 23, 8, p. 985-96 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2002

The caudate nucleus in obsessive-compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study

Hansen, E. S., Hasselbalch, S., Law, I. & Bolwig, T. G., Mar 2002, In: International Journal of Neuropsychopharmacology. 5, 1, p. 1-10 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2001

Benzodiazepine receptor quantification in Huntington's disease with [(123)I]omazenil and SPECT

Pinborg, L. H., Videbaek, C., Hasselbalch, S. G., Sørensen, S. A., Wagner, A., Paulson, O. B. & Knudsen, G. M., May 2001, In: Journal of neurology, neurosurgery, and psychiatry. 70, 5, p. 657-61 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Blood-brain barrier transport and brain metabolism of glucose during acute hyperglycemia in humans

Hasselbalch, S. G., Knudsen, G. M., Capaldo, B., Postiglione, A. & Paulson, O. B., May 2001, In: The Journal of clinical endocrinology and metabolism. 86, 5, p. 1986-90 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The (18)F-fluorodeoxyglucose lumped constant determined in human brain from extraction fractions of (18)F-fluorodeoxyglucose and glucose

Hasselbalch, S. G., Holm, S., Pedersen, H. S., Svarer, C., Knudsen, G. M., Madsen, P. L. & Paulson, O. B., Aug 2001, In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 21, 8, p. 995-1002 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2000

Dipyridamole dilates large cerebral arteries concomitant to headache induction in healthy subjects

Kruuse, C., Jacobsen, T. B., Lassen, L. H., Thomsen, L. L., Hasselbalch, S. G., Dige-Petersen, H. & Olesen, J., Sept 2000, In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 20, 9, p. 1372-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Effects of the non-selective phosphodiesterase inhibitor pentoxifylline on regional cerebral blood flow and large arteries in healthy subjects

Kruuse, C., Jacobsen, T. B., Thomsen, L. L., Hasselbalch, S. G., Frandsen, E. K., Dige-Petersen, H. & Olesen, J., Nov 2000, In: European Journal of Neurology. 7, 6, p. 629-38 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

1999

High dose insulin does not increase glucose transfer across the blood-brain barrier in humans: a re-evaluation

Knudsen, G. M., Hasselbalch, S. G., Hertz, M. M. & Paulson, O. B., Aug 1999, In: European Journal of Clinical Investigation. 29, 8, p. 687-91 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Impairment of neocortical metabolism predicts progression in Alzheimer's disease

Herholz, K., Nordberg, A., Salmon, E., Perani, D., Kessler, J., Mielke, R., Halber, M., Jelic, V., Almkvist, O., Collette, F., Alberoni, M., Kennedy, A., Hasselbalch, S., Fazio, F. & Heiss, W. D., 1999, In: Dementia and Geriatric Cognitive Disorders. 10, 6, p. 494-504 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans

Hasselbalch, S. G., Knudsen, G. M., Videbaek, C., Pinborg, L. H., Schmidt, J. F., Holm, S. & Paulson, O. B., Oct 1999, In: Diabetes. 48, 10, p. 1915-21 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1998

Activation-induced resetting of cerebral oxygen and glucose uptake in the rat

Madsen, P. L., Linde, R., Hasselbalch, S. G., Paulson, O. B. & Lassen, N. A., Jul 1998, In: Journal of Cerebral Blood Flow and Metabolism. 18, 7, p. 742-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

68 Citations (Scopus)

Calculation of the FDG lumped constant by simultaneous measurements of global glucose and FDG metabolism in humans

Hasselbalch, S. G., Madsen, P. L., Knudsen, G. M., Holm, S. & Paulson, O. B., Feb 1998, In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 18, 2, p. 154-60 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1996

Cerebral glucose metabolism is decreased in white matter changes in patients with phenylketonuria

Hasselbalch, S., Knudsen, G. M., Toft, P. B., Høgh, P., Tedeschi, E., Holm, S., Videbaek, C., Henriksen, O., Lou, H. C. & Paulson, O. B., Jul 1996, In: Pediatric Research. 40, 1, p. 21-4 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia

Hasselbalch, S. G., Madsen, P. L., Hageman, L. P., Olsen, K. S., Justesen, N., Holm, S. & Paulson, O. B., May 1996, In: American Journal of Physiology (Consolidated). 270, 5 Pt 1, p. E746-51

Research output: Contribution to journal › Journal article › Research › peer-review

Reduction of cerebral cortical [3H]ouabain binding site (Na+,K(+)-ATPase) density in dementia as evaluated in fresh human cerebral cortical biopsies

Schmidt, T. A., Hasselbalch, S., Larsen, J. S., Bundgaard, H., Juhler, M. & Kjeldsen, K., Nov 1996, In: Brain Research. 4, 4, p. 281-7 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transport of D-glucose and 2-fluorodeoxyglucose across the blood-brain barrier in humans

Hasselbalch, S. G., Knudsen, G. M., Holm, S., Hageman, L. P., Capaldo, B. & Paulson, O. B., Jul 1996, In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 16, 4, p. 659-66 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1995

Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans

Hasselbalch, S. G., Knudsen, G. M., Jakobsen, J., Hageman, L. P., Holm, S. & Paulson, O. B., Jun 1995, In: American Journal of Physiology (Consolidated). 268, 6 Pt 1, p. E1161-6

Research output: Contribution to journal › Journal article › Research › peer-review

Steen Hasselbalch

Research output

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