Signe Regner Michaelsen

2024

GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma

Avenel, I. C. N., Ewald, J. D., Ariey-Bonnet, J., Kristensen, I. H., Petterson, S. A., Thesbjerg, M. N., Burton, M., Thomassen, M., Wennerberg, K., Michaelsen, S. R. & Kristensen, B. W., 31 Jul 2024, In: Scientific Reports. 14, 1, p. 17639 17639.

Research output: Contribution to journal › Journal article › Research › peer-review

Glioblastoma cells increase expression of notch signaling and synaptic genes within infiltrated brain tissue

Harwood, D. S. L., Pedersen, V., Bager, N. S., Schmidt, A. Y., Stannius, T. O., Areškevičiūtė, A., Josefsen, K., Nørøxe, D. S., Scheie, D., Rostalski, H., Lü, M. J. S., Locallo, A., Lassen, U., Bagger, F. O., Weischenfeldt, J., Heiland, D. H., Vitting-Seerup, K., Michaelsen, S. R. & Kristensen, B. W., 9 Sept 2024, In: Nature Communications. 15, 1, 7857.

Research output: Contribution to journal › Journal article › Research › peer-review

Using GeoMx DSP Spatial Proteomics to Investigate Immune Infiltration of NOD Mouse Islet and Exocrine Compartments

Tekin, H., Lindhardt, C., Antvorskov, J. C., Bager, N. S., Michaelsen, S. R., Areškevičiūtė, A., Vind, J. P., Kristensen, B. W. & Josefsen, K., 18 Nov 2024, (E-pub ahead of print) In: Molecular Imaging and Biology.

Research output: Contribution to journal › Journal article › Research › peer-review

2023

Differential expression of checkpoint markers in the normoxic and hypoxic microenvironment of glioblastomas

Petterson, S. A., Sørensen, M. D., Burton, M., Thomassen, M., Kruse, T. A., Michaelsen, S. R. & Kristensen, B. W., Jan 2023, In: Brain pathology (Zurich, Switzerland). 33, 1, p. e13111 e13111.

Research output: Contribution to journal › Journal article › Research › peer-review

Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors

Puig-Blasco, L., Piotrowski, K. B., Michaelsen, S. R., Bager, N. S., Areškevičiūtiė, A., Thorseth, M.-L., Sun, X.-F., Keller, U. A. D., Kristensen, B. W., Madsen, D. H., Gnosa, S. P. & Kveiborg, M., 15 Dec 2023, In: International Journal of Cancer. 153, 12, p. 2068-2081 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2022

Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors

Knudsen, A. M., Halle, B., Cédile, O., Burton, M., Baun, C., Thisgaard, H., Anand, A., Hubert, C., Thomassen, M., Michaelsen, S. R., Olsen, B. B., Dahlrot, R. H., Bjerkvig, R., Lathia, J. D. & Kristensen, B. W., 1 Jul 2022, In: Neuro-Oncology. 24, 7, p. 1074-1087 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

2021

A Prognostic Model for Glioblastoma Patients Treated With Standard Therapy Based on a Prospective Cohort of Consecutive Non-Selected Patients From a Single Institution

Abedi, A. A., Grunnet, K., Christensen, I. J., Michaelsen, S. R., Muhic, A., Møller, S., Hasselbalch, B., Poulsen, H. S. & Urup, T., 25 Feb 2021, In: Frontiers in Oncology. 11, p. 1-9 9 p., 597587.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

2020

Angiotensinogen promoter methylation predicts bevacizumab treatment response of patients with recurrent glioblastoma

Urup, T., Gillberg, L., Kaastrup, K., Lü, M. J. S., Michaelsen, S. R., Andrée Larsen, V., Christensen, I. J., Broholm, H., Lassen, U., Grønbaek, K. & Poulsen, H. S., May 2020, In: Molecular Oncology. 14, 5, p. 964-973 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Genomic profiling of newly diagnosed glioblastoma patients and its potential for clinical utility - a prospective, translational study

Nørøxe, D. S., Yde, C. W., Østrup, O., Michaelsen, S. R., Schmidt, A. Y., Kinalis, S., Torp, M. H., Skjøth-Rasmussen, J., Brennum, J., Hamerlik, P., Poulsen, H. S., Nielsen, F. C. & Lassen, U., Nov 2020, In: Molecular Oncology. 14, 11, p. 2727-2743 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

2019

Cell-free DNA in newly diagnosed patients with glioblastoma - a clinical prospective feasibility study

Nørøxe, D. S., Østrup, O., Yde, C. W., Ahlborn, L. B., Nielsen, F. C., Michaelsen, S. R., Larsen, V. A., Skjøth-Rasmussen, J., Brennum, J., Hamerlik, P., Poulsen, H. S. & Lassen, U., 8 Jul 2019, In: Oncotarget. 10, 43, p. 4397-4406 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Clinical Characteristics of Gliosarcoma and Outcomes From Standardized Treatment Relative to Conventional Glioblastoma

Frandsen, S., Broholm, H., Larsen, V. A., Grunnet, K., Møller, S., Poulsen, H. S. & Michaelsen, S. R., 2019, In: Frontiers in Oncology. 9, p. 1425

Research output: Contribution to journal › Journal article › Research › peer-review

Extracranial metastases in glioblastoma-Two case stories

Schou Nørøxe, D., Regner Michaelsen, S., Broholm, H., Møller, S., Skovgaard Poulsen, H. & Lassen, U., 2019, In: Clinical Case Reports. 7, 2, p. 289-294 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

VEGF-C as a putative therapeutic target in cancer

Michaelsen, S. R., Poulsen, H. S. & Hamerlik, P., 18 Jun 2019, In: Oncotarget. 10, 40, p. 3988-3990 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2018

Analysis of molecules related to angiogenesis for advancement of glioblastoma treatment

Michaelsen, S. R., 2018, Faculty of Health and Medical Sciences, University of Copenhagen.

Research output: Book/Report › Ph.D. thesis

Angiotensinogen gene silencing predicts bevacizumab response in recurrent glioblastoma patients

Urup, T., Gillberg, L., Michaelsen, S. R., Christensen, I. J., Broholm, H., Lassen, U., Grønbæk, K. & Poulsen, H. S., 2018, p. 2027.

Research output: Contribution to conference › Poster › Research › peer-review

Biomarkers in Recurrent Grade III Glioma Patients Treated with Bevacizumab and Irinotecan

Toft, A., Urup, T., Christensen, I. J., Michaelsen, S. R., Lukram, B., Grunnet, K., Larsen, V. A., Lassen, U., Broholm, H. & Poulsen, H. S., 2018, In: Cancer Investigation. 36, 2, p. 165-174

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

DNA Methylation Levels of the ELMO Gene Promoter CpG Islands in Human Glioblastomas

Michaelsen, S. R., Aslan, D., Urup, T., Poulsen, H. S., Grønbæk, K., Broholm, H. & Kristensen, L. S., 28 Feb 2018, In: International Journal of Molecular Sciences. 19, 3, p. 679 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Molecular profiling of short-term and long-term surviving patients identifies CD34 mRNA level as prognostic for glioblastoma survival

Michaelsen, S. R., Urup, T., Olsen, L. R., Broholm, H., Lassen, U. & Poulsen, H. S., May 2018, In: Journal of Neuro-Oncology. 137, 3, p. 533-542 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B

Staberg, M., Rasmussen, R. D., Michaelsen, S. R., Pedersen, H., Jensen, K. E., Villingshøj, M., Skjoth-Rasmussen, J., Brennum, J., Vitting-Seerup, K., Poulsen, H. S. & Hamerlik, P., Mar 2018, In: Molecular Oncology. 12, 3, p. 406-420 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

51 Citations (Scopus)

VEGF-C Sustains VEGFR2 Activation under Bevacizumab Therapy and Promotes Glioblastoma Maintenance

Michaelsen, S. R., Staberg, M., Pedersen, H., Jensen, K. E., Majewski, W., Broholm, H., Nedergaard, M. K., Meulengracht, C., Urup, T., Villingshøj, M., Lukacova, S., Skjøth-Rasmussen, J., Brennum, J., Kjær, A., Lassen, U., Stockhausen, M.-T., Poulsen, H. S. & Hamerlik, P., 2018, In: Neuro-Oncology. 20, 11, p. 1462-74

Research output: Contribution to journal › Journal article › Research › peer-review

63 Citations (Scopus)

2017

Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine

Staberg, M., Michaelsen, S. R., Rasmussen, R. D., Villingshøj, M., Poulsen, H. S. & Hamerlik, P., Feb 2017, In: Cellular oncology (Dordrecht). 40, 1, p. 21–32 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Transcriptional changes induced by bevacizumab combination therapy in responding and non-responding recurrent glioblastoma patients

Urup, T., Staunstrup, L. M., Michaelsen, S. R., Vitting-Seerup, K., Bennedbæk, M., Toft, A., Olsen, L. R., Jønson, L., Issazadeh-Navikas, S., Broholm, H., Hamerlik, P., Poulsen, H. S. & Lassen, U., 18 Apr 2017, In: B M C Cancer. 17, 1, p. e278

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

2016

Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients

Urup, T., Michaelsen, S. R., Olsen, L. R., Toft, A., Christensen, I. J., Grunnet, K., Winther, O., Broholm, H., Kosteljanetz, M., Issazadeh-Navikas, S., Poulsen, H. S. & Lassen, U., Oct 2016, In: Molecular Oncology. 10, 8, p. 1160-1168

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Angiotensinogen and HLA Class II Predict Bevacizumab Response in Recurrent Glioblastoma Patients

Urup, T., Michaelsen, S. R., Olsen, L. R., Toft, A., Christensen, I. J., Grunnet, K., Winther, O., Broholm, H., Kosteljanetz, M., Issazadeh-Navikas, S., Poulsen, H. S. & Lassen, U., 2016.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma

Kristensen, L. S., Michaelsen, S. R., Dyrbye, H., Aslan, D., Grunnet, K., Christensen, I. J., Poulsen, H. S., Grønbæk, K. & Broholm, H., Mar 2016, In: Journal of Neuropathology and Experimental Neurology. 75, 3, p. 246-55 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro

Staberg, M., Michaelsen, S. R., Stobbe Olsen, M.-L., Nedergaard, M. K., Villingshøj, M., Stockhausen, M.-T., Hamerlik, P. & Poulsen, H. S., 26 Apr 2016, In: Cancer Cell Int. 16, p. 34

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Comparison of (18)F-FET and (18)F-FLT small animal PET for the assessment of anti-VEGF treatment response in an orthotopic model of glioblastoma

Nedergaard, M. K., Michaelsen, S. R., Perryman, L., Erler, J., Poulsen, H. S., Stockhausen, M., Lassen, U. & Kjaer, A., Mar 2016, In: Nuclear Medicine and Biology. 43, 3, p. 198-205 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Development and validation of a prognostic model for recurrent glioblastoma patients treated with bevacizumab and irinotecan

Urup, T., Dahlrot, R. H., Grunnet, K., Christensen, I. J., Michaelsen, S. R., Toft, A., Larsen, V. A., Broholm, H., Kosteljanetz, M., Hansen, S., Poulsen, H. S. & Lassen, U., 2016, In: Acta oncologica . 55, 4, p. 418-422 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Effects of bevacizumab combination therapy on transcriptional changes in responding and non-responding recurrent glioblastoma patients

Urup, T., Michaelsen, S. R., Staunstrup, L. M., Vitting-Seerup, K., Bennedbæk, M., Toft, A., Jønson, L., Broholm, H., Hamerlik, P., Poulsen, H. S. & Lassen, U., 2016.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Prognostic and Predictive Biomarkers in Recurrent WHO Grade 3 Glioma Patients Treated with Bevacizumab and Irinotecan

Toft, A., Urup, T., Christensen, I. J., Michaelsen, S. R., Singh, L. B., Grunnet, K., Kosteljanetz, M., Larsen, A. V. A., Broholm, H., Lassen, U. & Poulsen, H. S., 2016.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Quantitative and allelic methylation analyses of MGMT in gliobastoma

Kristensen, L. S., Michaelsen, S. R., Dyrbye, H., Aslan, D., Grunnet, K., Christensen, I. J., Poulsen, H. S., Grønbæk, K. & Broholm, H., 2016.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Urokinase-Type Plasminogen Activator Receptor as a Potential PET Biomarker in Glioblastoma

Persson, M., Nedergaard, M. K., Brandt-Larsen, M., Skovgaard, D., Jørgensen, J. T., Michaelsen, S. R., Madsen, J., Lassen, U., Poulsen, H. S. & Kjaer, A., Feb 2016, In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 57, 2, p. 272-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

VEGF-C contributes to autocrine VEGF Receptor 2 signaling and cellular maintenance in glioblastoma

Michaelsen, S. R., Nedergaard, M. K., Broholm, H., Bartkova, J., Staberg, M., Urup, T., Aghi, M., Lucacova, S., Villingshøj, M., Pedersen, P., Kjær, A., Perryman, L., Erler, J. T., Bartek, J., Lassen, U., Stockhausen, M., Poulsen, H. S. & Hamerlik, P., 2016.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

2015

18F-FET microPET and microMRI for anti-VEGF and anti-PlGF response assessment in an orthotopic murine model of human glioblastoma

Nedergaard, M. K., Michaelsen, S. R., Urup, T., Broholm, H., El Ali, H., Poulsen, H. S., Stockhausen, M.-T., Kjaer, A. & Lassen, U., 2015, In: P L o S One. 10, 2, p. e0115315

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

EPID-28. PROGNOSTIC AND PREDICTIVE BIOMARKERS IN RECURRENT WHO GRADE 3 GLIOMA PATIENTS TREATED WITH BEVACIZUMAB AND IRINOTECAN

Toft, A., Urup, T., Grunnet, K., Christensen, I. J., Michaelsen, S. R., Broholm, H., Singh, L. B., Larsen, V. A., Kosteljanetz, M., Lassen, U. & Poulsen, H. S., 2015.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

2014

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

Christensen, C. L., Kwiatkowski, N., Abraham, B. J., Carretero, J., Al-Shahrour, F., Zhang, T., Chipumuro, E., Herter-Sprie, G. S., Akbay, E. A., Altabef, A., Zhang, J., Shimamura, T., Capelletti, M., Reibel, J. B., Cavanaugh, J. D., Gao, P., Liu, Y., Michaelsen, S. R., Poulsen, H. S. & Aref, A. R. & 6 others, Barbie, D. A., Bradner, J. E., George, R. E., Gray, N. S., Young, R. A. & Wong, K.-K., 8 Dec 2014, In: Cancer Cell. 26, 6, p. 909-22 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

355 Citations (Scopus)

The impact of bevacizumab treatment on survival and quality of life in newly diagnosed glioblastoma patients

Poulsen, H. S., Urup, T., Michaelsen, S. R., Staberg, M., Villingshøj, M. & Lassen, U., 26 Sept 2014, In: Cancer Management and Research. 6, p. 373-87 15 p.

Research output: Contribution to journal › Review › peer-review

35 Citations (Scopus)

The use of longitudinal 18F-FET MicroPET imaging to evaluate response to irinotecan in orthotopic human glioblastoma multiforme xenografts

Nedergaard, M. K., Kristoffersen, K., Michaelsen, S. R., Madsen, J., Poulsen, H. S., Stockhausen, M.-T., Lassen, U. & Kjaer, A., 2014, In: P L o S One. 9, 2, p. e100009

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

2013

Clinical variables serve as prognostic factors in a model for survival from glioblastoma multiforme: an observational study of a cohort of consecutive non-selected patients from a single institution

Michaelsen, S. R., Christensen, I. J., Grunnet, K., Stockhausen, M.-T., Broholm, H., Kosteljanetz, M. & Poulsen, H. S., 3 Sept 2013, In: B M C Cancer. 13, 1, p. 402

Research output: Contribution to journal › Journal article › Research › peer-review

70 Citations (Scopus)

Signe Regner Michaelsen

Research output

Search results