Personal profile
Expertises
Immunology, Biotechnology, Tumor immunology
Main research areas
The immune system often fails to respond effectively against immunogenic antigens and become tolerant towards these antigens. We need to overcome this acquired state of tolerance for cancer immunotherapy to succeed. Immune regulatory proteins; e.g., programmed death-ligand 1 (PD-L1), PD-L2, indoleamine 2,3-dioxygenase (IDO), IDO2, tryptophan 2,3-dioxygenase (TDO), forkhead box P3 (Foxp3), and FoxO3 play a vital role in the immune suppression and tolerance induction of anti cancer immune responses. The main research area covers characterization and identification of self-reactive T cells that specifically recognized human leukocyte antigen (HLA)-restricted epitopes derived from these immune regulatory proteins.
Current research
My current research is based on identification and characterization of immune response against Programmed Cell Death Ligand 1 and 2 (PD-L1 and PD-L2) epitopes.
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Collaborations and top research areas from the last five years
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Harnessing Arginase-2-specific CD8+ T cells to target immunosuppressive Cutaneous T cell Lymphoma
Lisle, T. L., Weis-Banke, S. E., Ahmad, S. M., Holmström, M. O., Luu, T. V., Buus, T. B., Jessen, L. E., Dellgren, C., Barington, T., Met, Ö., Ødum, N. & Andersen, M. H., 19 Mar 2026, In: British Journal of Dermatology. 194, 4, p. 689-698 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates
Ruders, J. H., Ahmad, S. M., Mortensen, R. E. J., Met, Ö., Byrdal, M., Chen, I. M., Theile, S., Holmström, M. O. & Andersen, M. H., 24 Mar 2026, In: Signal Transduction and Targeted Therapy. 11, 1, 13 p., 107.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Arginase-1-specific T cells target and modulate tumor-associated macrophages
Martinenaite, E., Lecoq, I., Aaboe-Jørgensen, M., Ahmad, S. M., Perez-Penco, M., Glöckner, H. J., Chapellier, M., Lara De La Torre, L., Olsen, L. R., Rømer, A. M. A., Pedersen, A. W. & Andersen, M. H., 29 Jan 2025, In: Journal for ImmunoTherapy of Cancer. 13, 1, e009930.Research output: Contribution to journal › Journal article › Research › peer-review
24 Citations (Scopus) -
Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells
Glöckner, H. J., Martinenaite, E., Landkildehus Lisle, T., Grauslund, J., Ahmad, S., Met, Ö., Thor Straten, P. & Hald Andersen, M., 2024, In: OncoImmunology. 13, 1, p. 2318053 2318053.Research output: Contribution to journal › Journal article › Research › peer-review
4 Citations (Scopus) -
Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow
Holmström, M. O., Andersen, M., Traynor, S., Ahmad, S. M., Lisle, T. L., Handlos Grauslund, J., Skov, V., Kjær, L., Ottesen, J. T., Gjerstorff, M. F., Hasselbalch, H. C. & Andersen, M. H., 2023, In: Frontiers in Immunology. 14, p. 1240678 1240678.Research output: Contribution to journal › Journal article › Research › peer-review
10 Citations (Scopus)