Main research areas

Name: Pia Munkholm

Title: Professor,Consultant, DMSci

Current position:professor North Zealand hospital, Gastroenterology department

Education: medical doctor

 Research Experience:Ever scince 1982 my research has been about epidemiology in  IBD, -Crohn’s disease and ulcerative colitis and disease occurrence, course and prognosis.Pattern recognition of disease courses led in 1999 to development of web-applications in gastroenterology. Furthermore home-monitoring where PRO’s –Patient Reported Outcome implied guidance of medication with 5-aminisalisylates and higher up in treatment steps in the pyramid,5 eHealth phd’s inclusive in children, has proven that by “lead time bias” the patient obtain remission faster and for a longer period of time as the inflammation burden is less when the eHealth application support the IBD patients.

IBS-irritable bowel syndrome patients, have been added to the 12 web-applications where the Australian lowFODMAP show tremendous efficacy reaching 80 % remission rates.  

Recntly Children from 9-18 years have monitored themselves at home with disease activity scoring and Fecal calprotectin. Recently our group was rated top 10 in Europe, ECCO for development of a CalprSmartphone test used for homemoniroeing. Inflamation burden scoring cumulated from disease specific activity with fecal calprotectin was presented in a traffic light increasing adherence, compliance and patient empowerment.

Research Interest:Epidemiology in Europe, EpiCom group DCCD Danish Crohn Colitis database, constant-care web-applications. Furthermore fecal calprotectin web-app home-monitoring and microbiota has been set up in the eHealth gastroenterology laboratory.

Ongoing Research:eHealth influencing microbiome. Inflammationburden in IBD and IBS. Development of algorithm that comfort the consultant in mucosal healing by home-monitoring of intestinal inflammation level by fecal expression of calprotectin and the cange of microbiome.

 Communication: referral to university of Copenhagen and educating masterdegree in IT and Health under leadership of ass professor Lars Kayser: https://intranet.ku.dk/itsundhed_ka/

Potential conflicts of interest

none

Current research

Danish Center for eHealth & Epidemiology

Clinical Research Topics:

• Epidemiological studies of occurrence, disease course, pattern recognition, and prognosis of inflammatory bowel disease. This is done mainly by inception cohort studies and using web-based databases.
• Patient reported outcomes (including health related quality of life, fatigue, work disability) in patients with inflammatory bowel disease
• eHealth, self-monitoring and web-based treatment using web-based applications in patients with chronic diseases including inflammatory bowel disease and irritable bowel syndrome
• Studies of biomarkers with a focus on fecal calprotectin in patients with intestinal diseases
• Studies on IBS with LowFODMAP

Research responsible:

Head of research, professor Pia Munkholm, MD, DMSc. 48292078

[email protected]

eHealth IBD/IBS consultant, associate professor, PhD Mette Bennedsen; 48295246

 [email protected]

eHealth IBD sygeplejerske specialist Charlotte Teglgaard Peters-Lehm 

[email protected] 

Clinical Research Topics:

Clinical phase 3 trial Unit:

• BIO and BIO similar Randomised International Clinical trial for obtaining remission in IBD, inflammatory bowel diseases, Crohn’s and ulcerative colitis.

Research responsible:

consultant, MD, gastroenterologist Salvatore Leotta; 48294100

[email protected]

Liver, pancreas and Ultrasound fibrosis

• Liver Ultrasound evaluation of liverfibrosis

Research responsible:

Consultant, associate professor, PhD, Ulrich Rohde; 48294100

[email protected]