Research output per year
Research output per year
Personal profile
Expertises
Specialist in gastroenterology as well as in internal medicine. Expert Advisor to the Danish Health and Medicines Authority in internal medicine.
Main research areas
Management of medical gastroenterological disorders - especially inflammatory bowel disease - with emphasis on cellular and molecular mechanisms of inflammation with relevance for clinical and pharmacological improvement of treatment hereof.
Current research
Current research focuses on improved diagnosis and pharmacological management of inflammatory bowel disease. In collaboration with national (BRIC and Statens Serum INstitut) and international research groups (Leuven, Amsterdam, Zürich and Ottawa) the importance of the intestinal barrier maintenance of homeostasis / development of inflammation is studied, including the importance of intestinal stem cells. Additionally, epidemiological cohort studies are performed in patients with inflammatory bowel disease.
Potential conflicts of interest
None
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Network
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Comparative onset of effect of biologics and small molecules in moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis
Attauabi, M., Dahl, E. K., Burisch, J., Gubatan, J., Nielsen, O. H. & Seidelin, J. B., Mar 2023, In: EClinicalMedicine. 57, 101866.Research output: Contribution to journal › Journal article › Research › peer-review
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Deucravacitinib (Sotyktu™) for plaque psoriasis
Granau, A. M., Boye, T. L., Jensen, K. B. & Nielsen, O. H., Apr 2023, In: Trends in Pharmacological Sciences. 44, 4, p. 252-253 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
1 Citation (Scopus) -
Selective JAK1 inhibitors for the treatment of inflammatory bowel disease
Nielsen, O. H., Boye, T. L., Gubatan, J., Chakravarti, D., Jaquith, J. B. & LaCasse, E. C., May 2023, In: Pharmacology and Therapeutics. 245, 108402.Research output: Contribution to journal › Review › peer-review
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Biologics for Inflammatory Bowel Disease and Their Safety in Pregnancy: A Systematic Review and Meta-Analysis
Nielsen, O. H., Gubatan, J. M., Juhl, C. B., Streett, S. E. & Maxwell, C., Jan 2022, In: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 20, 1, p. 74-87.e3Research output: Contribution to journal › Review › peer-review
29 Citations (Scopus) -
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis
Holmstroem, R. B., Nielsen, O. H., Jacobsen, S., Riis, L. B., Theile, S., Bjerrum, J. T., Vilmann, P., Johansen, J. S., Boisen, M. K., Eefsen, R. H. L., Marie Svane, I., Nielsen, D. L. & Chen, I. M., 1 Sep 2022, In: Journal for ImmunoTherapy of Cancer. 10, 9, e005111.Research output: Contribution to journal › Journal article › Research › peer-review
6 Citations (Scopus)