Research output per year
Research output per year
Personal profile
Expertises
Molecular mechanisms of cancer invasion; Targeted drug delivery; Proteolytic enzymes; Endocytic receptors; Extracellular matrix; Antibody technology; Biomarkers (molecular aspects)
Main research areas
Cancer invasion; Targeted drug delivery; Extracellular matrix (ECM); Endocytic receptors; Extracellular proteolysis; Collagen and collagen turnover
Current research
We work to understand the cellular and biochemical mechanisms utilized by malignant tumor cells for destruction of neighboring tissues and the extracellular matrix (ECM) during the process of cancer invasion. These processes are a prerequisite for cancer metastasis. Furthermore, we work to exploit this knowledge for the development of novel cancer therapy. In particular, we study 1) the degradation mechanisms directed against collagens and other ECM components in cancer and the responsible proteolytic enzymes and cellular receptors; 2) strategies for therapeutic counteraction of these processes, and 3) targeted drug delivery to cancer cells, utilizing the cellular proteins of our primary interest.
Potential conflicts of interest
None
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Collaborations and top research areas from the last five years
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Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Grier, K. E., Hansen, A. H., Haxvig, C. S., Li, X., Krigslund, O., Behrendt, N., Engelholm, L. H., Rossi, F., Sousa, B. C., Harradence, G. J., Camper, N. & Qvortrup, K. M., 8 Jun 2023, In: Chemical Communications. 59, 47, p. 7240-7242 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1
Nørregaard, K. S., Jürgensen, H. J., Ingvarsen, S. Z., Heltberg, S. S., Hagensen, C. E., Gårdsvoll, H., Madsen, D. H., Jensen, O. N., Engelholm, L. H. & Behrendt, N., Aug 2022, In: Matrix biology : journal of the International Society for Matrix Biology. 111, p. 307-328 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Uncovering mediators of collagen degradation in the tumor microenvironment
Thorseth, M-L., Carretta, M., Jensen, C., Mølgaard, K., Jürgensen, H. J., Engelholm, L. H., Behrendt, N., Willumsen, N. & Madsen, D. H., Feb 2022, In: Matrix Biology Plus. 13, p. 100101 100101.Research output: Contribution to journal › Journal article › Research › peer-review
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Osteosarcoma and Metastasis Associated Bone Degradation-A Tale of Osteoclast and Malignant Cell Cooperativity
Nørregaard, K. S., Jürgensen, H. J., Gårdsvoll, H., Engelholm, L. H., Behrendt, N. & Søe, K., Jul 2021, In: International Journal of Molecular Sciences. 22, 13, 6865.Research output: Contribution to journal › Review › peer-review
23 Citations (Scopus) -
The collagen receptor uparap in malignant mesothelioma: A potential diagnostic marker and therapeutic target
Çakılkaya, P., Sørensen, R. R., Jürgensen, H. J., Krigslund, O., Gårdsvoll, H., Nielsen, C. F., Santoni‐rugiu, E., Behrendt, N. & Engelholm, L. H., 23 Oct 2021, In: International Journal of Molecular Sciences. 22, 21, 11452.Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus)