Omics research in diabetic kidney disease: new biomarker dimensions and new understandings?

Tofte, N., Persson, F. & Rossing, P., 30 May 2020, In : Journal of Nephrology.

Plasma metabolomics identifies markers of impaired renal function: A meta-analysis of 3,089 persons with type 2 diabetes

Tofte, N., Vogelzangs, N., Mook-Kanamori, D., Brahimaj, A., Nano, J., Ahmadizar, F., Willems van Dijk, K., Frimodt-Møller, M., Arts, I., Beulens, J. W. J., Rutters, F., van der Heijden, A. A., Kavousi, M., Stehouwer, C. D. A., Nijpels, G., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Rossing, P., Ahluwalia, T. S. & 't Hart, L. M., 9 Apr 2020, In : The Journal of clinical endocrinology and metabolism. dgaa173.

Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial

PRIORITY investigators, 1 Apr 2020, In : The Lancet Diabetes and Endocrinology. 8, 4, p. 301-312 12 p.

Changes in diabetes distress among people with type 2 diabetes during a risk screening programme for diabetic kidney disease - Longitudinal observations of the PRIORITY study

Joensen, L. E., Madsen, K. P., Frimodt-Møller, M., Tofte, N., Willaing, I., Lindhardt, M. & Rossing, P., 1 Jan 2020, In : Journal of Diabetes and its Complications. 34, 1, 107467.

Metabolomic assessment reveals alteration in polyols and branched chain amino acids associated with present and future renal impairment in a discovery cohort of 637 persons with type 1 diabetes

Tofte, N., Suvitaival, T., Trošt, K., Mattila, I., Theilade, S., Winther, S. A., Ahluwalia, T. S., Frimodt-Møller, M., Legido-Quigley, C. & Rossing, P., 22 Nov 2019, In : Frontiers in Endocrinology. 10, p. 1-11 11 p., 818.

Lipidomic analysis reveals sphingomyelin and phosphatidylcholine species associated with renal impairment and all-cause mortality in type 1 diabetes

Tofte, N., Suvitaival, T., Ahonen, L., Winther, S. A., Theilade, S., Frimodt-Møller, M., Ahluwalia, T. S. & Rossing, P., 8 Nov 2019, In : Scientific Reports. 9, 1, 10 p., 16398.

Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy

Tofte, N., Lindhardt, M. K., Currie, G., Frimodt-Møller, M., von der Leyen, H., Delles, C., Mischak, H. & Rossing, P., Oct 2019, In : Journal of the American Society of Nephrology. 30, p. 1 72 p., FR-OR113 .

Polyols and Branched Chained Amino Acids Are Associated with Present and Future Renal Impairment in Type 1 Diabetes

Tofte, N., Suvitaival, T., Trošt, K., Mattila, I., Theilade, S., Winther, S. A., Ahluwalia, T. S., Frimodt-Møller, M., Legido-Quigley, C. & Rossing, P., Oct 2019, In : Journal of the American Society of Nephrology. 30, p. 362 1 p., TH-PO934.

Spironolactone for the prevention of microalbuminuria in high risk type 2 diabetes: Results from the multicenter randomized double-blind controlled study "PRIORITY"

Lindhardt, M. K., Tofte, N., Frimodt-Møller, M., Currie, G., Delles, C., von der Leyen, H., Mischak, H. & Rossing, P., Oct 2019, In : Journal of the American Society of Nephrology. 30, p. 498 1 p., FR-PO247.

Visit-to-Visit Variability of Albuminuria and eGFR as Risk Markers for Renal Complications, Cardiovascular Events, and Mortality in Type 1 Diabetes

Curovic, V. R., Theilade, S., Winther, S. A., Tofte, N., Jorsal, A., Parving, H-H., Persson, F., Hansen, T. & Rossing, P., Oct 2019, In : Journal of the American Society of Nephrology. 30, p. 904 1 p., SA-PO552.

Markers of Collagen Formation and Degradation Reflect Renal Function and Predict Adverse Outcomes in Patients With Type 1 Diabetes

Pilemann-Lyberg, S., Rasmussen, D. G. K., Hansen, T. W., Tofte, N., Winther, S. A., Nielsen, S. H., Theilade, S., Karsdal, M. A., Genovese, F. & Rossing, P., 1 Sep 2019, In : Diabetes Care. 42, 9, p. 1760-1768 9 p.

Circulating metabolites are associated with present and future renal impairment in type 1 Diabetes

Tofte, N., Suvitaival, T., Trošt, K., Mattila, I., Theilade, S., Winther, S. A., Ahluwalia, T. S., Frimodt-Møller, M., Legido-Quigley, C. & Rossing, P., Sep 2019, In : Diabetologia. 62, Suppl 1, p. 30 1 p., 57.

Plasma metabolomics identifies markers of kidney function in 3,064 Europeans with type 2 diabetes

Ahluwalia, T. S., Tofte, N., Vogelzangs, N., Mook-Kanamori, D., Brahimaj, A., Frimodt-Møller, M., Arts, I., Beulens, J., van der Heijden, A., Stehouwer, C., Nijpels, G., van Greevenbroek, M., van der Kallen, C., Rossing, P. & t' Hart, L. M., Sep 2019, In : Diabetologia. 62, Suppl 1, p. 456 1 p., 937.

Renal function dominates the landscape of the metabolome in type 1 diabetes

Suvitaival, T., Tofte, N., Mattila, I., Trošt, K., Theilade, S., Winther, S. A., Ahluwalia, T. S., Frimodt-Møller, M., Rossing, P. & Legido-Quigley, C., Sep 2019, In : Diabetologia. 62, Suppl 1, p. 455 1 p., 936.

The utility of plasma concentration of Trimethylamine-N-Oxide in predicting cardiovascular and renal complications in individuals with type 1 diabetes

Winther, S. A., Øllgaard, J. C., Tofte, N., Tarnow, L., Wang, Z., Ahluwalia, T. S., Jorsal, A., Theilade, S., Parving, H. H., Hansen, T., Hazen, S. L., Pedersen, O. & Rossing, P., Sep 2019, In : Diabetologia. 62, Suppl 1, p. 32 1 p., 60.

Visit-to-visit variability of HbA1c and systolic BP as risk markers for cardiovascular events, end stage renal disease, renal function decline and mortality in type 1 diabetes

Curovic, V. R., Theilade, S., Winther, S. A., Tofte, N., Tarnow, L., Jorsal, A., Parving, H. H., Persson, F., Hansen, T. W. & Rossing, P., Sep 2019, In : Diabetologia. 62, Suppl 1, p. 568 1 p., 1181.

Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes

Winther, S. A., Øllgaard, J. C., Tofte, N., Tarnow, L., Wang, Z., Ahluwalia, T. S., Jorsal, A., Theilade, S., Parving, H-H., Hansen, T. W., Hazen, S. L., Pedersen, O. & Rossing, P., Aug 2019, In : Diabetes Care. 42, 8, p. 1512-1520 9 p.

Soluble Urokinase Plasminogen Activator Receptor Predicts Cardiovascular Events, Kidney Function Decline, and Mortality in Patients With Type 1 Diabetes

Rotbain Curovic, V., Theilade, S., Winther, S. A., Tofte, N., Eugen-Olsen, J., Persson, F., Hansen, T. W., Jeppesen, J. & Rossing, P., 1 Jun 2019, In : Diabetes Care. 42, 6, p. 1112-1119 8 p.

Uric acid is an independent risk factor for decline in kidney function, cardiovascular events, and mortality in patients with type 1 diabetes

Pilemann-Lyberg, S., Hansen, T. W., Tofte, N., Winther, S. A., Theilade, S., Ahluwalia, T. S. & Rossing, P., 1 Jun 2019, In : Diabetes Care. 42, 6, p. 1088-1094 7 p.

Plasma lipids are associated with diabetic kidney disease: a study of plasma lipidomics in type 1 diabetes

Tofte, N., Suvitaival, T., Ahonen, L. L., Theilade, S., Winther, S. A., Frimodt-Møller, M., Ahluwalia, T. S. & Rossing, P., 26 Oct 2018, In : Journal of the American Society of Nephrology. 29, p. 535 1 p., FR-PO445.

Plasma metabolomics identifies markers of impaired kidney function: A meta-analyses of 1,984 Europeans with type 2 diabetes

Tofte, N., Ahluwalia, T. S., Vogelzangs, N., Mook-Kanamori, D., Brahimaj, A., Nano, J., van Dijk, K. W., Frimodt-Møller, M., van der Kallen, C., Arts, I., Beulens, J., van der Heijden, A., Nijpels, G., van Greevenbroek, M., Stehouwer, C., Rossing, P. & t' Hart, L. M., 26 Oct 2018, In : Journal of the American Society of Nephrology. 29, p. 535 1 p., FR-PO446.

Pulse Wave Velocity Is an Independent Risk Factor for Cardiovascular Events, Mortality and Decline in Renal Function in Patients with Type 1 Diabetes

Frimodt-Møller, M., Theilade, S., Winther, S. A., Tofte, N., Ahluwalia, T. S. & Rossing, P., 26 Oct 2018, In : Journal of the American Society of Nephrology. 29, 1, FR-PO430.

Soluble Urokinase Plasminogen Activator Receptor Predicts Kidney Function Decline and Mortality in Patients with Type 1 Diabetes

Rotbain Curovic, V., Theilade, S., Winther, S. A., Tofte, N., Eugen-Olsen, J., Persson, F., Hansen, T. W., Jeppesen, J. L. & Rossing, P., 26 Oct 2018, In : Journal of the American Society of Nephrology. 29, p. 537 1 p., FR-PO453.

Uric acid is an independent risk factor for mortality, cardiovascular event and decline in kidney function in patients with type 1 diabetes

Pilemann-Lyberg, S., Hansen, T. W., Tofte, N., Winther, S. A., Theilade, S., Ahluwalia, T. S. & Rossing, P., 26 Oct 2018, In : Journal of the American Society of Nephrology. 29, p. 537 1 p., FR-PO454.

Pulse Wave Velocity is an Independent Risk Factor for Cardiovascular Events, Mortality and progression in diabetic kidney disease in patients with type 1 diabetes

Hansen, T. W., Frimodt-Møller, M., Theilade, S., Winther, S. A., Tofte, N., Ahluwalia, T. S. & Rossing, P., 4 Oct 2018, In : Diabetologia. 61, Suppl 1, p. S548-S548 1 p., 1123.

Markers of collagen formation and degradation reflect renal function and predict adverse outcome in type 1 diabetes

Pilemann-Lyberg, S., Hansen, T. W., Tofte, N., Winther, S. A., Theilade, S., Rasmussen, D. G. K., Nielsen, S., Karsdal, M. A., Genovese, F. & Rossing, P., 2 Oct 2018, In : Diabetologia. 61, S1, p. S491 1 p., 999.

Soluble urokinase plasminogen activator receptor predicts cardiovascular events, mortality and kidney function decline in patients with type 1 diabetes

Curovic, V. R., Theilade, S., Winther, S. A., Tofte, N., Eugen-Olsen, J., Persson, F., Hansen, T. W., Jeppesen, J. & Rossing, P., 1 Oct 2018, In : Diabetologia. 61, 1, p. S577-S578 1 p., 1183.

How Does Risk Screening for Kidney Disease Influence Diabetes Distress?

Joensen, L. E., Madsen, K. P., Frimodt-Møller, M., Tofte, N., Willaing, I., Lindhardt, M. K. & Rossing, P., 1 Jul 2018, In : Diabetes. 67, Supplement 1, 1 p.

Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes

Tofte, N., Lindhardt, M., Adamova, K., Beige, J., Beulens, J. W. J., Birkenfeld, A. L., Currie, G., Delles, C., Dimos, I., Francová, L., Frimodt-Møller, M., Girman, P., Göke, R., Havrdova, T., Kooy, A., Mischak, H., Navis, G., Nijpels, G., Noutsou, M., Ortiz, A., Parvanova, A., Persson, F., Ruggenenti, P. L., Rutters, F., Rychlík, I., Spasovski, G., Speeckaert, M., Trillini, M., von der Leyen, H. & Rossing, P., 21 May 2018, In : Diabetic Medicine. 35, 10, p. 1375-1382 8 p.

Altered levels of plasma lipids are associated with diabetic kidney disease: a cross-sectional study of plasma lipidomics in type 1 diabetes

Tofte, N., Suvitaival, T., Ahonen, L. L., Theilade, S., Ahluwalia, T. S., Frimodt-Møller, M. & Rossing, P., May 2018, In : Nephrology Dialysis Transplantation. 33, Suppl 1, 1 p., SP420 .

Plasma lipids are associated with diabetic kidney disease: a study of plasma lipidomics in type 1 diabetes

Tofte, N., Suvitaival, T., Ahonen, L. L., Theilade, S., Winther, S. A., Frimodt-Møller, M., Ahluwalia, T. S. & Rossing, P., 2018, In : Diabetologia. 61, suppl 1, p. S497-S497 1 p., 1011.

Chronic urinary tract infections in patients with spinal cord lesions - biofilm infection with need for long-term antibiotic treatment

Tofte, N., Nielsen, A. C. Y., Trøstrup, H., Andersen, C. B., Von Linstow, M., Hansen, B., Biering-Sørensen, F., Høiby, N. & Moser, C., 1 Apr 2017, In : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 125, 4, p. 385-391

Use of prophylactic voriconazole for three months after lung transplantation does not reduce infection with Aspergillus: a retrospective study of 147 patients

Tofte, N., Jensen, C. V., Tvede, M., Andersen, C. B., Carlsen, J. & Iversen, M., 2012, In : Scandinavian Journal of Infectious Diseases. 44, 11, p. 835-41 7 p.