Personal profile
Expertises
signaling pathways; inflammation; lipid metabolism; cancer stem cells; small molecule inhibitors; western blot; imaging; flow cytometry; mouse models
Main research areas
Cancer – Acute Myeloid Leukaemia; AML mouse models and AML xenograft models; Stem Cell Biology; Oncogenic signalling; targeted therapies/precision medicine; preclinical trials.
Current research
Characterise the molecular mechanisms of crosstalking signalling pathways in cancer patients with acute myeloid leukaemia (AML) and define how targeting of these pathways will affect growth and survival of primary cancer cells in preclinical trials
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Collaborations and top research areas from the last five years
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The glycosaminoglycan oncofetal chondroitin sulfate is a novel target for antibody-drug conjugate therapy for AML
Mujollari, J., Estruch Alrich, M., Khadgawat, P., Choudhary, S., Gustavsson, T., Dagil, R., Redlinger, N., Løppke, C., Vidal Calvo, E., Anemone Nordmaj, M., Theander, T. G., Heidenreich, O., Nguyen, Y., Qin, S., Tølbøll Sørensen, A. L., Grønbæk, K., Porse, B. T., Kircher, B., Mueller, J. & Agerbæk, M. & 2 others, , 12 Mar 2026, In: Blood. 147, 11, p. 1229-1236 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration
Engelhard, S., Estruch, M., Qin, S., Engelhard, C. A., Rodriguez-Gonzalez, F. G., Drilsvik, M., Martin-Gonzalez, J., Lu, J.-W., Bryder, D., Nerlov, C., Weischenfeldt, J., Reckzeh, K. & Theilgaard-Mönch, K., 23 Jul 2024, In: Cell reports. 43, 7, 114475.Research output: Contribution to journal › Journal article › Research › peer-review
6 Citations (Scopus) -
Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML
Centio, A., Estruch, M., Reckzeh, K., Sanjiv, K., Vittori, C., Engelhard, S., Warpman Berglund, U., Helleday, T. & Theilgaard-Mönch, K., 4 May 2022, In: Molecular Cancer Therapeutics. 21, 5, p. 703-714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
TET2 deficiency cooperates with CBFB-MYH11 to induce acute myeloid leukaemia and represents an early leukaemogenic event
Reckzeh, K., Estruch, M., Ali, M., Søgaard Helbo, A., Mosbech, A., Jae Won, K., Rücker, F., Döhner, K. & Theilgaard-Mönch, K., Apr 2022, In: British Journal of Haematology. 197, 2, p. 201-206 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus) -
MTH1 inhibitor TH1579 induces oxidative DNA damage and mitotic arrest in acute myeloid leukemia
Sanjiv, K., Calderón-Montaño, J. M., Pham, T. M., Erkers, T., Tsuber, V., Almlöf, I., Höglund, A., Heshmati, Y., Seashore-Ludlow, B., Nagesh Danda, A., Gad, H., Wiita, E., Göktürk, C., Rasti, A., Friedrich, S., Centio, A., Estruch, M., Våtsveen, T. K., Struyf, N. & Visnes, T. & 12 others, , 15 Nov 2021, In: Cancer Research. 81, 22, p. 5733-5744 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
27 Citations (Scopus)