Research output per year
Research output per year
Personal profile
Expertises
signaling pathways; inflammation; lipid metabolism; cancer stem cells; small molecule inhibitors; western blot; imaging; flow cytometry; mouse models
Main research areas
Cancer – Acute Myeloid Leukaemia; AML mouse models and AML xenograft models; Stem Cell Biology; Oncogenic signalling; targeted therapies/precision medicine; preclinical trials.
Current research
Characterise the molecular mechanisms of crosstalking signalling pathways in cancer patients with acute myeloid leukaemia (AML) and define how targeting of these pathways will affect growth and survival of primary cancer cells in preclinical trials
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Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML
Centio, A., Estruch, M., Reckzeh, K., Sanjiv, K., Vittori, C., Engelhard, S., Warpman Berglund, U., Helleday, T. & Theilgaard-Mönch, K., 4 May 2022, In: Molecular Cancer Therapeutics. 21, 5, p. 703-714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TET2 deficiency cooperates with CBFB-MYH11 to induce acute myeloid leukaemia and represents an early leukaemogenic event
Reckzeh, K., Estruch, M., Ali, M., Søgaard Helbo, A., Mosbech, A., Jae Won, K., Rücker, F., Döhner, K. & Theilgaard-Mönch, K., Apr 2022, In: British Journal of Haematology. 197, 2, p. 201-206 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MTH1 inhibitor TH1579 induces oxidative DNA damage and mitotic arrest in acute myeloid leukemia
Sanjiv, K., Calderón-Montaño, J. M., Pham, T. M., Erkers, T., Tsuber, V., Almlöf, I., Höglund, A., Heshmati, Y., Seashore-Ludlow, B., Nagesh Danda, A., Gad, H., Wiita, E., Göktürk, C., Rasti, A., Friedrich, S., Centio, A., Estruch, M., Våtsveen, T. K., Struyf, N., Visnes, T., & 12 others, 15 Nov 2021, In: Cancer Research. 81, 22, p. 5733-5744 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Combination Treatments for AML
Alrich, M. E., Vittori, C., Muños-Montesinos, T., Reckzeh, K. & Theilgaard-Mönch, K., 26 Jul 2021, In: Journal of Cellular Immunology. p. 240 245 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeted inhibition of cooperative mutation- and therapy-induced AKT activation in AML effectively enhances response to chemotherapy
Estruch, M., Reckzeh, K., Vittori, C., Centio, A., Ali, M., Engelhard, S., Zhao, L., Won, K. J., Liu, P., Porse, B. T. & Theilgaard-Mönch, K., Jul 2021, In: Leukemia. 35, 7, p. 2030-2042 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
9 Citations (Scopus)