Research output per year
Research output per year
Personal profile
Expertises
Measurement and visualization of O2 depletion
Bacterial susceptibility test with antibiotics on biofilm
Detection of reactive O2 species with different techniques
Operating a hyperbaric oxygen chamber
Main research areas
My main research interest is the effect of host responses on bacterial susceptibility to antibiotics. It has become clear that host cells may cause limited oxygen availability in bacterial infections, whereby a stratified physiology occurs, that is associated with increased tolerance of antibiotics.
Current research
i am currently investigating the effect of supplementation of O2 under hyperbaric pressure in combibation with antibiotics on bacteial biofilm in order to increase the bactericidal activity of antibiotics.
Potential conflicts of interest
I have no conflict of interest
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Collaborations and top research areas from the last five years
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Adaptation of Pseudomonas aeruginosa biofilms to tobramycin and the quorum sensing inhibitor C-30 during experimental evolution requires multiple genotypic and phenotypic changes
Bové, M., Kolpen, M., Lichtenberg, M., Bjarnsholt, T. & Coenye, T., Jan 2023, In: Microbiology (Reading, England). 169, 1, 001278.Research output: Contribution to journal › Journal article › Research › peer-review
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Antimicrobial resistance of Pseudomonas aeruginosa in a cystic fibrosis population after introduction of a novel cephalosporin/β-lactamase inhibitor combination
Katzenstein, T. L., Faurholt-Jepsen, D., Qvist, T., Jensen, P. Ø., Pressler, T., Johansen, H. K. & Kolpen, M., Aug 2023, In: APMIS - Journal of Pathology, Microbiology and Immunology. 131, 8, p. 419-425 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exhaled nitric oxide in intubated ICU patients on mechanical ventilation - a feasibility study
Kofoed, A., Hindborg, M., Hjembaek Brandt, J., Sørensen, C., Kolpen, M. & Bestle, M. H., 1 Sep 2023, (E-pub ahead of print) In: Journal of breath research.Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperbaric oxygen therapy augments ciprofloxacin effect against Pseudomonas aeruginosa biofilm infected chronic wounds in a mouse model
Laulund, A. S., Schwartz, F. A., Christophersen, L., Kolpen, M., Østrup Jensen, P., Calum, H., Høiby, N., Thomsen, K. & Moser, C., Dec 2023, In: Biofilm. 5, 100100.Research output: Contribution to journal › Journal article › Research › peer-review
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Adaptive Immune Response to Mycobacterium abscessus Complex (MABSC) in Cystic Fibrosis and the Implications of Cross-Reactivity
Mauch, R. M., Jensen, P. Ø., Qvist, T., Kolpen, M., Moser, C., Pressler, T., Nolasco da Silva, M. T., Høiby, N., Copenhagen Study Group on Mycobacterial Infections in Cystic Fibrosis, Faurholt-Jepsen, D., Wareham, N. E. & Katzenstein, T., 20 Apr 2022, In: Frontiers in cellular and infection microbiology. 12, 858398.Research output: Contribution to journal › Journal article › Research › peer-review