Mette Christensen

Research output

Research output per year 2007 2010 2015 2018 2019 2023

• 27 Journal article
• 2 Conference abstract in journal

Research output per year

Research output per year

Search results

• 2023

  Pathogenic variants in GCSH encoding the moonlighting H-protein cause combined Nonketotic Hyperglycinemia and Lipoate Deficiency

  Arribas-Carreira, L., Dallabona, C., Swanson, M. A., Farris, J., Østergaard, E., Tsiakas, K., Hempel, M., Aquaviva-Bourdain, C., Koutsoukos, S., Stence, N. V., Magistrati, M., Spector, E. B., Kronquist, K., Christensen, M., Karstensen, H. G., Feichtinger, R. G., Achleitner, M. T., Lawrence Merritt, J., Pérez, B., Ugarte, M., & 11 othersGrünewald, S., Riela, A. R., Julve, N., Arnoux, J-B., Haldar, K., Donnini, C., Santer, R., Lund, A. M., Mayr, J. A., Rodriguez-Pombo, P. & Van Hove, J. L. K., 6 Mar 2023, In: Human Molecular Genetics. 32, 6, p. 917-933 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nonketotic Hyperglycinemia 100%
  • Lipoylation 51%
  • Proteins 22%
  • Oxidoreductases 21%
  • glycine cleavage system 21%
• 2022

  The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model

  Ahring, K. K., Dagnæs-Hansen, F., Brüel, A., Christensen, M., Jensen, E., Jensen, T. G., Johannsen, M., Johansen, K. S., Lund, A. M., Madsen, J. G., Brøndum-Nielsen, K., Pedersen, M., Sørensen, L. K., Kjolby, M. & Møller, L. B., 2022, In: PLoS One. 17, 1, p. 1-26 26 p., e0261150.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • caseinomacropeptide 100%
  • Phenylketonurias 71%
  • Caseins 64%
  • Amino Acids 38%
  • Phenylalanine 29%

• The impact of metabolic supply lines - and the patterns between them - on the development of distant metastases in 64 women with breast cancer

  Abrahamsen, O., Balslev, E., Christensen, M., Wibrand, F., Budtz-Jørgensen, E. & Høgdall, E., Sep 2022, In: Oncology letters. 24, 3, p. 327 327.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Breast Neoplasms 100%
  • Neoplasm Metastasis 96%
  • Equipment and Supplies Utilization 88%
  • Cystathionine 81%
  • Glucose 65%
• 2021

  Citrulline as a biomarker of bacteraemia during induction treatment for childhood acute lymphoblastic leukaemia

  De Pietri, S., Frandsen, T. L., Christensen, M., Grell, K., Rathe, M. & Müller, K., Jan 2021, In: Pediatric Blood & Cancer. 68, 1, p. e28793 e28793.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Citrulline 100%
  • Bacteremia 78%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 75%
  • Biomarkers 50%
  • Neutrophils 34%
  8 Citations (Scopus)
• 2020

  Danish expanded newborn screening is a successful preventive public health programme

  Lund, A., Wibrand, F., Skogstrand, K., Cohen, A., Christensen, M., Jäpelt, R. B., Dunø, M., Skovby, F., Nørgaard-Pedersen, B., Gregersen, N., Andresen, B. S., Olsen, R. K. J. & Hougaard, D., Jan 2020, In: Danish Medical Journal. 67, 1

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Preventive Health Services 100%
  • Neonatal Screening 95%
  • Public Health 57%
  • Newborn Infant 44%
  • Child 20%
• 2019

  Diagnostic pitfalls in vitamin B6-dependent epilepsy caused by mutations in the PLPBP gene

  Jensen, K. V., Frid, M., Stödberg, T., Barbaro, M., Wedell, A., Christensen, M., Bak, M., Ek, J., Madsen, C. G., Darin, N. & Grønborg, S., 2019, In: JIMD Reports. 50, 1, p. 1-8 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vitamin B 6 100%
  • Vitamin 80%
  • Mutation 66%
  • Epilepsy 66%
  • Pyridoxal Phosphate 63%

• Functional disruption of pyrimidine nucleoside transporter CNT1 results in a novel inborn error of metabolism with high excretion of uridine and cytidine

  Wevers, R. A., Christensen, M., Engelke, U. F. H., Geuer, S., Coene, K. L. M., Kwast, J. T., Lund, A. M. & Vissers, L. E. L. M., 2019, In: Journal of Inherited Metabolic Disease. 42, 3, p. 494-500 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pyrimidine Nucleosides 100%
  • Nucleoside Transport Proteins 95%
  • Cytidine 88%
  • Inborn Errors Metabolism 81%
  • Uridine 77%

• Hydroxylated Long-Chain Acylcarnitines are Biomarkers of Mitochondrial Myopathy

  Vissing, C. R., Dunø, M., Wibrand, F., Christensen, M. & Vissing, J., 1 Dec 2019, In: The Journal of clinical endocrinology and metabolism. 104, 12, p. 5968-5976 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mitochondrial Myopathies 100%
  • acylcarnitine 95%
  • Biological Marker 61%
  • Mutation 57%
  • Neuromuscular 47%

• Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

  Dahl, R. H., Berg, R. M. G., Taudorf, S., Bailey, D. M., Lundby, C., Christensen, M., Larsen, F. S. & Møller, K., 17 Nov 2019, In: Scandinavian Journal of Clinical and Laboratory Investigation. 79, 8, p. 595-600 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Neutral Amino Acids 100%
  • Hypoxia 54%
  • Kinetics 49%
  • Aromatic Amino Acids 32%
  • Aromatic Amino Acid 26%
  2 Citations (Scopus)
• 2018

  Compound heterozygous mutations in two different domains of ALDH18A1 do not affect the amino acid levels in a patient with hereditary spastic paraplegia

  Steenhof, M., Kibæk, M., Larsen, M. J., Christensen, M., Lund, A. M., Brusgaard, K. & Hertz, J. M., 12 May 2018, In: Neurogenetics. 19, 3, p. 145-149

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hereditary Spastic Paraplegia 100%
  • delta-1-pyrroline-5-carboxylate 59%
  • Amino Acids 47%
  • glutamate 5-kinase 41%
  • Mutation 37%
  10 Citations (Scopus)

• Hyperglucagonemia correlates with plasma levels of non-branched chained amino acids in patients with liver disease independent of type 2 diabetes

  Wewer Albrechtsen, N. J., Junker, A. E., Christensen, M., Hædersdal, S., Wibrand, F., Lund, A. M., Galsgaard, K. D., Holst, J. J., Knop, F. K. & Vilsbøll, T., 10 Jan 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. p. ajpgi.00216.2017

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Liver Diseases 100%
  • Non-alcoholic Fatty Liver Disease 89%
  • Type 2 Diabetes Mellitus 89%
  • Glucagon 86%
  • Amino Acids 83%
  46 Citations (Scopus)

• Simultaneous quantification of succinylacetone and nitisinone for therapeutic drug monitoring in the treatment of Tyrosinemia type 1

  Sundberg, J., Wibrand, F., Lund, A. M. & Christensen, M., 2018, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1072, p. 259-266 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nitisinone 100%
  • nitisinone 86%
  • succinylacetone 82%
  • Tyrosinemias 72%
  • Drug Monitoring 54%
  5 Citations (Scopus)

• Styrene Exposure and Risk of Lymphohematopoietic Malignancies in 73,036 Reinforced Plastics Workers

  Christensen, M. S., Vestergaard, J. M., d'Amore, F., Gørløv, J. S., Toft, G., Ramlau-Hansen, C. H., Stokholm, Z. A., Iversen, I. B., Nissen, M. S. & Kolstad, H. A., May 2018, In: Epidemiology (Cambridge, Mass.). 29, 3, p. 342-351 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Styrene 100%
  • Plastics 68%
  • Occupational Groups 51%
  • Neoplasms 22%
  • Acute Myeloid Leukemia 22%
  15 Citations (Scopus)
• 2016

  Effect of Female Body Mass Index on Oocyte Quantity in Fertility Treatments (IVF): Treatment Cycle Number Is a Possible Effect Modifier. A Register-Based Cohort Study

  Christensen, M. W., Ingerslev, H. J., Degn, B. & Kesmodel, U. S., 23 Sep 2016, In: P L o S One. 11, 9, p. e0163393

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fertilization in Vitro 100%
  • Fertility 87%
  • Oocytes 86%
  • Body Mass Index 66%
  • Cohort Studies 63%
  18 Citations (Scopus)
• 2015

  Abnormal Newborn Screening in a Healthy Infant of a Mother with Undiagnosed Medium-Chain Acyl-CoA Dehydrogenase Deficiency

  Aksglaede, L., Christensen, M., Olesen, J. H., Duno, M., Olsen, R. K. J., Andresen, B. S., Hougaard, D. M. & Lund, A. M., 13 Mar 2015, In: JIMD Reports. 23, p. 67-70

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Medium chain acyl CoA dehydrogenase deficiency 100%
  • Carnitine 81%
  • Acyl-CoA 77%
  • Neonatal Screening 70%
  • acylcarnitine 42%

• Associations between gastrointestinal toxicity, micro RNA and cytokine production in patients undergoing myeloablative allogeneic stem cell transplantation

  Pontoppidan, P. L., Jordan, K., Carlsen, A. L., Uhlving, H. H., Kielsen, K., Christensen, M., Ifversen, M., Nielsen, C. H., Sangild, P., Heegaard, N. H. H., Heilmann, C., Sengeløv, H. & Müller, K., Mar 2015, In: International Immunopharmacology. 25, 1, p. 180-8 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Allogeneic Cells 100%
  • Stem Cell Transplantation 97%
  • MicroRNAs 78%
  • Hematopoietic Stem Cell Transplantation 70%
  • Cytokines 57%
  25 Citations (Scopus)

• CLPB Variants Associated with Autosomal-Recessive Mitochondrial Disorder with Cataract, Neutropenia, Epilepsy, and Methylglutaconic Aciduria

  Saunders, C., Smith, L., Wibrand, F., Ravn, K., Bross, P., Thiffault, I., Christensen, M., Atherton, A., Farrow, E., Miller, N., Kingsmore, S. F. & Ostergaard, E., 5 Feb 2015, In: American Journal of Human Genetics. 96, 2, p. 258-65 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Endopeptidase Clp 100%
  • Mitochondrial Diseases 71%
  • 3-Methylglutaconic Aciduria 71%
  • Neutropenia 57%
  • Cataract 53%
  44 Citations (Scopus)

• Mild Lesch-Nyhan Disease in a Boy with a Null Mutation inHPRT1: An Exception to the Known Genotype-Phenotype Correlation

  Bayat, A., Christensen, M., Wibrand, F., Duno, M. & Lund, A., 2015, In: JIMD Reports. 18, p. 135-37

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lesch-Nyhan Syndrome 100%
  • Loss of Function Mutation 72%
  • Genetic Association Studies 68%
  • Hypoxanthine Phosphoribosyltransferase 59%
  • Mutation 54%

• Sentinel Lymph Node Dissection in Locally Recurrent Breast Cancer

  Caspara Uth, C., Christensen, M. H., Oldenbourg, M. H., Kjær, C., Garne, J. P., Teilum, D., Kroman, N. & Tvedskov, T. F., 2015, In: Annals of Surgical Oncology. 22, 8, p. 2526-2531 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sentinel Lymph Node 100%
  • Lymph Node Excision 79%
  • Breast Neoplasms 52%
  • Recurrence 17%
  • Lymphoscintigraphy 17%
  16 Citations (Scopus)
• 2013

  Lixisenatide for the treatment of type 2 diabetes

  Petersen, A. B., Knop, F. K. & Christensen, M., Sep 2013, In: Drugs of Today. 49, 9, p. 537-53 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • lixisenatide 100%
  • Type 2 Diabetes Mellitus 44%
  • Glucagon-Like Peptide-1 Receptor 37%
  • Fasting 15%
  • Liraglutide 13%
  18 Citations (Scopus)

• Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies

  Calanna, S., Christensen, M., Holst, J., Laferrère, B., Gluud, L. L., Vilsbøll, T. & Knop, F. K., May 2013, In: Diabetologia Praktyczna. 56, 5, p. 965-72 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Type 2 Diabetes Mellitus 64%
  • Meta-Analysis 63%
  • Systematic Reviews 62%
  • Clinical Studies 59%
  180 Citations (Scopus)
• 2012

  Biochemical screening of 504,049 newborns in Denmark, the Faroe Islands and Greenland - Experience and development of a routine program for expanded newborn screening

  Lund, A. M., Hougaard, D. M., Simonsen, H., Andresen, B. S., Christensen, M., Dunø, M., Skogstrand, K., Olsen, R. K. J., Jensen, U. G., Cohen, A., Larsen, N. B., Saugmann-Jensen, P., Gregersen, N., Brandt, N. J., Christensen, E., Skovby, F. & Nørgaard-Pedersen, B., 2012, In: Molecular Genetics and Metabolism. 107, 3, p. 281-93 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Greenland 100%
  • Neonatal Screening 77%
  • Denmark 70%
  • Disorder 56%
  • Inborn Errors Metabolism 50%
  57 Citations (Scopus)

• MCAD deficiency in Denmark

  Andresen, B. S., Lund, A. M., Hougaard, D. M., Christensen, E., Gahrn, B., Christensen, M., Bross, P. G., Vested, A., Simonsen, H., Skogstrand, K., Olpin, S., Brandt, N. J., Skovby, F., Nørgaard-Pedersen, B. & Gregersen, N., 2012, In: Molecular Genetics and Metabolism. 106, 2, p. 175-88 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Medium chain acyl CoA dehydrogenase deficiency 100%
  • Acyl-CoA 77%
  • Denmark 64%
  • Mutation 29%
  • Neonatal Screening 23%
  31 Citations (Scopus)
• 2010

  Clinical and biochemical monitoring of patients with fatty acid oxidation disorders

  Lund, A. M., Skovby, F., Vestergaard, H., Christensen, M. & Christensen, E., 1 Oct 2010, In: Journal of Inherited Metabolic Disease. 33, 5, p. 495-500 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Physiologic Monitoring 100%
  • Fatty Acids 80%
  • Carnitine 56%
  • Systemic carnitine deficiency 53%
  • acylcarnitine 44%
  24 Citations (Scopus)

• Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones

  Christensen, M. K., Erichsen, K. D., Trojel-Hansen, C., Tjørnelund, J., Nielsen, S. J., Frydenvang, K. A., Johansen, T. N., Nielsen, B., Sehested, M., Jensen, P. B. L., Ikaunieks, M., Zaichenko, A., Loza, E., Kalvinsh, I. & Björkling, F., 14 Oct 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7140-5 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oxyphenisatin Acetate 100%
  • Antiproliferative 98%
  • Antitumor 91%
  • Heterografts 88%
  • Dose 75%
  51 Citations (Scopus)

• Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

  Olesen, U. H., Petersen, J. G., Garten, A., Kiess, W., Yoshino, J., Imai, S-I., Christensen, M. K., Fristrup, P., Thougaard, A. V., Björkling, F., Jensen, P. B. L., Nielsen, S. J. & Sehested, M., 1 Jan 2010, In: B M C Cancer. 10, p. 677

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 1-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)-4-(N'-cyano-N''-(6-(4-chlorophenoxy)hexyl)-N-guanidino)pyridinium 100%
  • N-(6-chlorophenoxyhexyl)-N''-cyano-N''-4-pyridylguanidine 88%
  • Nicotinamide Phosphoribosyltransferase 61%
  • N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 45%
  • Pharmacology 29%
  42 Citations (Scopus)

• Urethral Pressure Reflectometry Is Valuable for Evaluating Pharmacological Therapies for Stress Urinary Incontinence

  Klarskov, N., Scholfield, D., Darekar, A., Christensen, M. & Lose, G., 2010, In: International Urogynecology Journal. 21, p. S166-S168

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Urethral Pressure Reflectometry Is Valuable for Evaluating Pharmacological Therapies for Stress Urinary Incontinence

  Klarskov, N., Scholfield, D., Darekar, A., Christensen, M. & Lose, G., 2010, In: Neurourology and Urodynamics. 29, 6, p. 970-972 3 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
• 2007

  Treatment of mitochondrial neurogastrointestinal encephalomyopathy with dialysis

  Yavuz, H., Ozel, A., Christensen, M., Christensen, E., Schwartz, M., Elmaci, M. & Vissing, J., Mar 2007, In: Archives of Neurology. 64, 3, p. 435-8 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mitochondrial Encephalomyopathies 100%
  • Dialysis 55%
  • Nucleosides 41%
  • Deoxyuridine 34%
  • Peritoneal Dialysis 28%