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The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2020
  2. Published
  3. Published

    Towards selective CNS PET imaging of the 5-HT7 receptor system: Past, present and future

    L'Estrade, E. T., Erlandsson, M., Edgar, F. G., Ohlsson, T., Knudsen, G. M. & Herth, M. M., 1 Aug 2020, In: Neuropharmacology. 172, p. 107830 107830.

    Research output: Contribution to journalReviewpeer-review

  4. Published
  5. Published

    Characterization of the serotonin 2A receptor selective PET tracer (R)-[18F]MH.MZ in the human brain

    Kramer, V., Dyssegaard, A., Flores, J., Soza-Ried, C., Rösch, F., Knudsen, G. M., Amaral, H. & Herth, M. M., Feb 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47, 2, p. 355-365 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors

    L 'Estrade, E. T., Shalgunov, V., Edgar, F. G., Strebl-Bantillo, M. G., Xiong, M., Crestey, F., Neelamegam, R., Dyssegaard, A., Lehel, S., Erlandsson, M., Ohlsson, T., Hooker, J. M., Knudsen, G. M., Herth, M. M. & Hansen, H. D., Feb 2020, In: Journal of Labelled Compounds and Radiopharmaceuticals. 63, 2, p. 46-55 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

    Stéen, E. J. L., Jørgensen, J. T., Johann, K., Nørregaard, K., Sohr, B., Svatunek, D., Birke, A., Shalgunov, V., Edem, P. E., Rossin, R., Seidl, C., Schmid, F., Robillard, M. S., Kristensen, J. L., Mikula, H., Barz, M., Kjær, A. & Herth, M. M., 28 Jan 2020, In: ACS Nano. 14, 1, p. 568-584 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors

    Bratteby, K., Torkelsson, E., L'Estrade, E. T., Peterson, K., Shalgunov, V., Xiong, M., Leffler, H., Zetterberg, F. R., Olsson, T. G., Gillings, N., Nilsson, U. J., Herth, M. M. & Erlandsson, M., 23 Jan 2020, In: Journal of Medicinal Chemistry. 63, 2, p. 747-755 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging

    Edem, P. E., Jørgensen, J. T., Nørregaard, K., Rossin, R., Yazdani, A., Valliant, J. F., Robillard, M., Herth, M. M. & Kjaer, A., 22 Jan 2020, In: Molecules. 25, 3

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2019
  11. Published

    Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies

    Perani, D., Iaccarino, L., Jacobs, A. H., IMBI Brain Imaging Working Group, Herth, M. M. & Knudsen, G. M., Dec 2019, In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 11, p. 327-332 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    One-Step Synthesis of N-Succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB)

    Nymann Petersen, I., Madsen, J., Bernard Matthijs Poulie, C., Kjær, A. & Manfred Herth, M., 22 Sep 2019, In: Blood Cells, Molecules, and Diseases. 24, 19

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Development and Evaluation of Two Potential 5-HT7 Receptor PET Tracers: [18F]ENL09 and [18F]ENL10

    Tampio L 'Estrade, E., Xiong, M., Shalgunov, V., Edgar, F. G., Volk, B., Baerentzen, S. L., Palner, M., Erlandsson, M., Ohlsson, T., Knudsen, G. M. & Herth, M. M., 18 Sep 2019, In: ACS Chemical Neuroscience. 10, 9, p. 3961-3968 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking

    Denk, C., Wilkovitsch, M., Aneheim, E., Herth, M. M., Jensen, H., Lindegren, S. & Mikula, H., Jul 2019, In: ChemPlusChem. 84, 7, p. 775-778 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

    L'Estrade, E. T., Hansen, H. D., Falk-Petersen, C., Haugaard, A., Griem-Krey, N., Jung, S., Lüddens, H., Schirmeister, T., Erlandsson, M., Ohlsson, T., Knudsen, G. M., Herth, M. M., Wellendorph, P. & Frølund, B., 31 May 2019, In: ACS omega. 4, 5, p. 8846-8851 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

    Edem, P. E., Sinnes, J-P., Pektor, S., Bausbacher, N., Rossin, R., Yazdani, A., Miederer, M., Kjær, A., Valliant, J. F., Robillard, M. S., Rösch, F. & Herth, M. M., 28 May 2019, In: EJNMMI Research. 9, 1, p. 49

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging

    Stéen, E. J. L., Jørgensen, J. T., Petersen, I. N., Nørregaard, K., Lehel, S., Shalgunov, V., Birke, A., Edem, P. E., L'Estrade, E. T., Hansen, H. D., Villadsen, J., Erlandsson, M., Ohlsson, T., Yazdani, A., Valliant, J. F., Kristensen, J. L., Barz, M., Knudsen, G. M., Kjær, A. & Herth, M. M., 15 Apr 2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 8, p. 986-990 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

    Griem-Krey, N., Klein, A. B., Herth, M. & Wellendorph, P., 12 Mar 2019, In: Journal of visualized experiments : JoVE. 145, p. e

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Convenient Entry to 18F-Labeled Amines through the Staudinger Reduction

    Stéen, E. J. L., Shalgunov, V., Denk, C., Mikula, H., Kjær, A., Kristensen, J. L. & Herth, M. M., 28 Feb 2019, In: European Journal of Organic Chemistry. 2019, 8, p. 1722-1725 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Evaluation of [18 F]2FP3 in pigs and non-human primates

    Hansen, H. D., Constantinescu, C. C., Barret, O., Herth, M. M., Magnussen, J. H., Lehel, S., Dyssegaard, A., Colomb, J., Billard, T., Zimmer, L., Tamagnan, G. & Knudsen, G. M., 1 Jan 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, 1, p. 34-42 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Development and Evaluation of Two Potential 5-HT7Receptor PET Tracers: [18F]ENL09 and [18F]ENL10

    L'Estrade, E. T., Xiong, M., Shalgunov, V., Fraser, G., Volk, B., Baerentzen, S. L., Palner, M., Erlandsson, M., Ohlsson, T., Knudsen, G. M. & Herth, M. M., 2019, In: A C S Chemical Neuroscience. 10, 9, p. 3961 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Radiolabeling and in vivo evaluation of 11C-AGH-44: a potential lead structure to develop a positron emission tomography radioligand for the 5-HT7 receptor

    L'Estrade, E. T., Petersen, I. N., Xiong, M., Hogendorf, A. S., Hogendorf, A., Langgaard Kristensen, J., Kjær, A., Bojarski, A. J., Erlandsson, M., Ohlsson, T., Knudsen, G. M. & Herth, M. M., 2019, In: Journal of Radioanalytical Chemistry. 322, 2, p. 847 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Synthesis, Radiolabeling and in Vitro and in Vivo Evaluation of 18F-ENL30: A Potential PET Radiotracer for the 5-HT7 Receptor

    L'Estrade, E. T., Herth, M. M., Fraser, G. E., Xiong, M., Shalgunov, V., Baerentzen, S. L., Erlandsson, M., Ohlsson, T., Palner, M. & Knudsen, G. M., 2019, In: ACS omega. 4, p. 7344 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
  25. 2018
  26. Published

    Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines

    Stéen, E. J. L., Edem, P. E., Nørregaard, K., Jørgensen, J. T., Shalgunov, V., Kjaer, A. & Herth, M. M., Oct 2018, In: Biomaterials. 179, p. 209-245 37 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging

    T L'Estrade, E., Hansen, H. D., Erlandsson, M., Ohlsson, T. G., Knudsen, G. M. & Herth, M. M., 20 Jun 2018, In: ACS Chemical Neuroscience. 9, 6, p. 1226-1229 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Fluorine-18 Radiolabeling Strategies – Advantages and Disadvantages of Currently Applied Labeling Methods

    Edem, P. E., Stéen, E. J. L., Kjær, A. & Herth, M. M., 2018, Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  29. Published

    PET Imaging of the 5-HT2A Receptor System: A Tool to Study the Receptor’s In Vivo Brain Function

    Herth, M. M. & Knudsen, G. M., 2018, 5HT2A Receptors in the Central Nervous System. The Receptors. Guiard, B. & Di Giovanni, G. (eds.). Vol. 32. p. 85-134

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  30. 2017
  31. Published

    Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT2A receptor agonists [(18) F]Cimbi-92 and [(18) F]Cimbi-150

    Edgar, F. G., Hansen, H. D., Leth-Petersen, S., Ettrup, A., Kristensen, J. L., Knudsen, G. M. & Herth, M. M., Oct 2017, In: Journal of Labelled Compounds and Radiopharmaceuticals. 60, 12, p. 586-591 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    (18)F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands

    Petersen, I. N., Villadsen, J., Hansen, H. D., Madsen, J., Jensen, A. A., Gillings, N., Lehel, S., Herth, M. M., Knudsen, G. M. & Kristensen, J. L., 23 May 2017, In: Organic & biomolecular chemistry. 15, 20, p. 4351-4358 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites

    Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, R. P., Knudsen, G. M., Herth, M. M., Wellendorph, P. & Frølund, B., 18 Jan 2017, In: ACS Chemical Neuroscience. 8, 1, p. 22-27 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices

    Stéen, E. J. L., Nyberg, N., Lehel, S., Lykke Andersen, V., Di Pilato, P., Knudsen, G. M., Kristensen, J. L. & Herth, M. M., 15 Jan 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 319-322 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2016
  36. Published

    Convergent (18)F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands

    Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, A. A., Lehel, S., Gillings, N., Herth, M. M., Knudsen, G. M. & Kristensen, J. L., 1 Nov 2016, In: Bioorganic and Medicinal Chemistry. 24, 21, p. 5353-5356 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Synthesis and evaluation of (18)F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, M. M., Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, A. A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, J. L., 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The Center for Integrated Molecular Brain Imaging (Cimbi) database

    Knudsen, G. M., Jensen, P. S., Erritzoe, D., Baaré, W. F. C., Ettrup, A., Fisher, P. M., Gillings, N., Hansen, H. D., Hansen, L. K., Hasselbalch, S. G., Henningsson, S., Herth, M. M., Holst, K. K., Iversen, P., Kessing, L. V., Macoveanu, J., Madsen, K. S., Mortensen, E. L., Nielsen, F. Å., Paulson, O. B., Siebner, H. R., Stenbæk, D. S., Svarer, C., Jernigan, T. L., Strother, S. C. & Frokjaer, V. G., 1 Jan 2016, In: NeuroImage. 124, p. 1213-1219 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    In Vivo Radionuclide Generators for Diagnostics and Therapy

    Edem, P. E., Fonslet, J., Kjær, A., Herth, M. & Severin, G., 2016, In: Bioinorganic Chemistry and Applications. 2016, p. 6148357 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2015
  41. Published

    Current radiosynthesis strategies for 5-HT2A receptor PET tracers

    Herth, M. M. & Knudsen, G. M., 15 Jun 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, 7, p. 265-73 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Labeling and preliminary in vivo evaluation of the 5-HT(7) receptor selective agonist [(11)C]E-55888

    Hansen, H. D., Lykke Andersen, V., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, J. L., Knudsen, G. M. & Herth, M. M., 1 May 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published
  44. Published

    (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand

    Lykke Andersen, V., Hansen, H. D., Herth, M. M., Dyssegaard, A., Knudsen, G. M. & Kristensen, J. L., 1 Mar 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 5, p. 1053-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2014
  46. Published

    (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand

    Lykke Andersen, V., Hansen, H. D., Herth, M. M., Knudsen, G. M. & Langgaard Kristensen, J., 1 Jun 2014, In: Bioorganic & Medicinal Chemistry Letters. 24, 11, p. 2408-11 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Synthesis, radiolabeling and in vivo evaluation of [(11)C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT(7) receptor

    Hansen, H. D., Lacivita, E., Di Pilato, P., Herth, M. M., Lehel, S., Ettrup, A., Lykke Andersen, V., Dyssegaard, A., De Giorgio, P., Perrone, R., Berardi, F., Colabufo, N. A., Niso, M., Knudsen, G. M. & Leopoldo, M., 22 May 2014, In: European Journal of Medicinal Chemistry. 79, p. 152-63 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes

    Herth, M. M., Leth-Petersen, S., Lehel, S., Hansen, M., Knudsen, G. M., Gillings, N., Madsen, J. & Kristensen, J. L., 30 Apr 2014, In: R S C Advances. 4, 41, p. 21347-21350 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published
  50. Published

    Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor

    Lacivita, E., Niso, M., Hansen, H. D., Di Pilato, P., Herth, M. M., Lehel, S., Ettrup, A., Montenegro, L., Perrone, R., Berardi, F., Colabufo, N. A., Leopoldo, M. & Knudsen, G. M., 23 Jan 2014, In: Bioorganic & Medicinal Chemistry. 22, 5, p. 1736-1750

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2013
  52. Published

    Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation

    Herth, M. M., Andersen, V. L., Lehel, S., Madsen, J., Knudsen, G. M. & Kristensen, J. L., 2013, In: Chemical Communications. 49, 36, p. 3805-7 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published
  54. Published

    Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl-11C-methanes

    Andersen, V. L., Herth, M. M., Lehel, S., Knudsen, G. M. & Kristensen, J. L., 2013, In: Tetrahedron Letters. 54, 3, p. 213 216 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 2012
  56. Published

    Direct radiofluorination of [18F]MH.MZ for 5-HT2A receptor molecular imaging with PET

    Herth, M. M., Kramer, V., Gillings, N., Rösch, F. & Knudsen, G. M., 2012, In: Journal of Labelled Compounds and Radiopharmaceuticals. 55, 9, p. 354 358 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Direct radiofluorination of [18F]MH.MZ for 5-HT2A receptor molecular imaging with PET

    Herth, M. M., Kramer, V., Gillings, N., Rösch, F. & Knudsen, G. M., 2012, In: Journal of Labelled Compounds and Radiopharmaceuticals. 55, 9, p. 354-358 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Synthesis and evaluation of [¹¹C]Cimbi-806 as a potential PET ligand for 5-HT₇ receptor imaging

    Herth, M. M., Hansen, H. D., Ettrup, A., Dyssegaard, A., Lehel, S., Kristensen, J. L. & Knudsen, G. M., 2012, In: Bioorganic & Medicinal Chemistry. 20, 14, p. 4574-81 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Synthesis and in vitro evaluation of oxindole derivatives as potential radioligands for 5-HT(7) receptor imaging with PET

    Herth, M. M., Volk, B., Pallagi, K., Kofoed Bech, L., Antoni, F. A., Knudsen, G. M. & Kristensen, J. L., 2012, In: A C S Chemical Neuroscience. 3, 12, p. 1002-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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