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The Capital Region of Denmark - a part of Copenhagen University Hospital

Matej Orešič

(Former)

  1. 2019
  2. Published

    Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients

    Ahonen, L., Jäntti, S., Suvitaival, T., Theilade, S., Risz, C., Kostiainen, R., Rossing, P., Orešič, M. & Hyötyläinen, T., 14 Sep 2019, In : Metabolites. 9, 9, 184.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Circulating metabolites in progression to islet autoimmunity and type 1 diabetes

    Lamichhane, S., Kemppainen, E., Trošt, K., Siljander, H., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M. & Orešič, M., 23 Aug 2019, In : Diabetologia.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children

    Madrid-Gambin, F., Föcking, M., Sabherwal, S., Heurich, M., English, J. A., O'Gorman, A., Suvitaival, T., Ahonen, L., Cannon, M., Lewis, G., Mattila, I., Scaife, C., Madden, S., Hyötyläinen, T., Orešič, M., Zammit, S., Cagney, G., Cotter, D. R. & Brennan, L., 1 Jul 2019, In : Biological Psychiatry. 86, 1, p. 25-34 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

    Lamichhane, S., Ahonen, L., Dyrlund, T. S., Dickens, A. M., Siljander, H., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M. & Oresic, M., 21 Jan 2019, In : Biomolecules. 9, 1, 9 p., 33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2018
  7. Published

    A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes

    Lamichhane, S., Ahonen, L., Dyrlund, T. S., Siljander, H., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M. & Orešič, M., 13 Nov 2018, In : Scientific Data. 5, p. 180250

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Serum metabolites associate with CT findings following TBI

    Dickens, A. M., Posti, J. P., Takala, R. S., Ala-Seppälä, H. M., Mattila, I., Coles, J. C., Frantzén, J., Hutchinson, P. J., Katila, A. J., Kyllönen, A., Maanpää, H-R., Newcombe, V., Outtrim, J., Tallus, J., Carpenter, K., Menon, D., Hyotylainen, T., Tenovuo, O. & Oresic, M., 1 Nov 2018, In : Journal of Neurotrauma. 35, 22, p. 2673–2683 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes

    Grip, T., Dyrlund, T. S., Ahonen, L., Domellöf, M., Hernell, O., Hyötyläinen, T., Knip, M., Lönnerdal, B., Orešič, M. & Timby, N., 4 Aug 2018, In : Pediatric Research. 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

    Luukkonen, P. K., Sädevirta, S., Zhou, Y., Kayser, B., Ali, A., Ahonen, L., Lallukka, S., Pelloux, V., Gaggini, M., Jian, C., Hakkarainen, A., Lundbom, N., Gylling, H., Salonen, A., Orešič, M., Hyötyläinen, T., Orho-Melander, M., Rissanen, A., Gastaldelli, A., Clément, K., Hodson, L. & Yki-Järvinen, H., Jul 2018, In : Diabetes Care. 41, 7

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Platform for systems medicine research and diagnostic applications in psychotic disorders-The METSY project

    Frank, E., Maier, D., Pajula, J., Suvitaival, T., Borgan, F., Butz-Ostendorf, M., Fischer, A., Hietala, J., Howes, O., Hyötyläinen, T., Janssen, J., Laurikainen, H., Moreno, C., Suvisaari, J., Van Gils, M. & Orešič, M., Apr 2018, In : European psychiatry : the journal of the Association of European Psychiatrists. 50, p. 40-46 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor

    Orešič, M., Anderson, G., Mattila, I., Manoucheri, M., Soininen, H., Hyötyläinen, T. & Basignani, C., 9 Jan 2018, In : Frontiers in Neuroscience. 11, p. 747

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men

    Suvitaival, T., Bondia-Pons, I., Yetukuri, L., Pöhö, P., Nolan, J. J., Hyötyläinen, T., Kuusisto, J. & Orešič, M., 1 Jan 2018, In : Metabolism: Clinical and Experimental. 78, p. 1-12 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2017
  15. Published

    Harmonizing Lipidomics: NIST Interlaboratory Comparison Exercise for Lipidomics using Standard Reference Material 1950 Metabolites in Frozen Human Plasma

    Bowden, J. A., Heckert, A., Ulmer, C. Z., Jones, C. M., Koelmel, J. P., Abdullah, L., Ahonen, L., Alnouti, Y., Armando, A., Asara, J. M., Bamba, T., Barr, J. R., Bergquist, J., Borchers, C. H., Brandsma, J., Breitkopf, S. B., Cajka, T., Cazenave-Gassiot, A., Checa, A., Cinel, M. A., Colas, R. A., Cremers, S., Dennis, E. A., Evans, J. E., Fauland, A., Fiehn, O., Gardner, M. S., Garrett, T. J., Gotlinger, K. H., Han, J., Huang, Y., Neo, A. H., Hyotylainen, T., Izumi, Y., Jiang, H., Jiang, H., Jiang, J., Kachman, M., Kiyonami, R., Klavins, K., Klose, C., Kofeler, H. C., Kolmert, J., Koal, T., Koster, G., Kuklenyik, Z., Kurland, I. J., Leadley, M., Lin, K., Maddipati, K. R., McDougall, D., Meikle, P. J., Mellett, N. A., Monnin, C., Moseley, M. A., Nandakumar, R., Oresic, M., Patterson, R. E., Peake, D., Pierce, J. S., Post, M., Postle, A. D., Pugh, R., Qui, Y., Quehenberger, O., Ramrup, P., Rees, J., Rembiesa, B., Reynaud, D., Roth, M. R., Sales, S., Schuhmann, K., Schwartzman, M. L., Serhan, C. N., Shevchenko, A., Somerville, S. E., John-Williams, L. S., Surma, M. A., Takeda, H., Thakare, R., Thompson, J. W., Torta, F., Triebl, A., Trotzmuller, M., Ubhayasekera, S. J. K., Vuckovic, D., Weir, J. M., Welti, R., Wenk, M. R., Wheelock, C. E., Yao, L., Yuan, J-M., Zhao, X. H. & Zhou, S., Dec 2017, In : Journal of Lipid Research. 58, p. 2275-2288 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

    O'Gorman, A., Suvitaival, T., Ahonen, L., Cannon, G. M., Zammit, S., Lewis, G., Roche, H. M., Mattila, I., Hyotylainen, T., Orešič, M., Brennan, L. & Cotter, D. R., 26 Sep 2017, In : Translational psychiatry. 7, 9, p. e1240

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study

    Jørgenrud, B., Stene, L. C., Tapia, G., Bøås, H., Pepaj, M., Berg, J. P., Thorsby, P. M., Orešič, M., Hyotylainen, T. & Rønningen, K. S., 1 Mar 2017, In : Pediatric Diabetes. 18, 2, p. 111-119 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2016
  19. Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis

    Suvitaival, T., Mantere, O., Kieseppä, T., Mattila, I., Pöhö, P., Hyotylainen, T., Suvisaari, J. & Orešič, M., 15 Nov 2016, In : Translational psychiatry. 6, 11, p. e951

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury

    Orešič, M., Posti, J. P., Kamstrup-Nielsen, M. H., Takala, R. S. K., Lingsma, H. F., Mattila, I., Jäntti, S., Katila, A. J., Carpenter, K. L. H., Ala-Seppälä, H., Kyllönen, A., Maanpää, H-R., Tallus, J., Coles, J. P., Heino, I., Frantzén, J., Hutchinson, P. J., Menon, D. K., Tenovuo, O. & Hyotylainen, T., Oct 2016, In : EBioMedicine. 12, p. 118-126 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)

    Kurko, J., Tringham, M., Tanner, L., Näntö-Salonen, K., Vähä-Mäkilä, M., Nygren, H., Pöhö, P., Lietzen, N., Mattila, I., Olkku, A., Hyötyläinen, T., Orešič, M., Simell, O., Niinikoski, H. & Mykkänen, J., Sep 2016, In : Metabolism: Clinical and Experimental. 65, 9, p. 1361-75 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Human gut microbes impact host serum metabolome and insulin sensitivity

    Gudmundsdottir, V., Hyötyläinen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Doré, J., Mattila, I., Plichta, D. R., Pöhö, P., Hellgren, L. I., Arumugam, M., Sunagawa, S., Vieira-Silva, S., Jørgensen, T., Holm, J. B., Trošt, K., Consortium, MIT., Kristiansen, K., Brix, S., Raes, J., Wang, J., Hansen, T., Bork, P., Brunak, S., Orešič, M., Ehrlich, S. D. & Pedersen, O., 13 Jul 2016, In : Nature. 535, p. 376-81

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites

    Vetrani, C., Rivellese, A. A., Annuzzi, G., Adiels, M., Borén, J., Mattila, I., Orešič, M. & Aura, A-M., Jul 2016, In : The Journal of nutritional biochemistry. 33, p. 111-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease

    Hyötyläinen, T., Jerby, L., Petäjä, E. M., Mattila, I., Jäntti, S., Auvinen, P., Gastaldelli, A., Yki-Järvinen, H., Ruppin, E. & Orešič, M., 3 Feb 2016, In : Nature Communications. 7, p. 8994

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2015
  26. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes

    DIABIMMUNE Study Group, 11 Feb 2015, In : Cell Host & Microbe. 17, 2, p. 260-73 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. The influence of sample collection methodology and sample preprocessing on the blood metabolic profile

    Jørgenrud, B., Jäntti, S., Mattila, I., Pöhö, P., Rønningen, K. S., Yki-Järvinen, H., Orešič, M. & Hyötyläinen, T., 2015, In : Bioanalysis. 7, 8, p. 991-1006 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2014
  29. The DEXLIFE study methods: identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals

    Andersen, G. S., Thybo, T., Cederberg, H., Orešič, M., Esteller, M., Zorzano, A., Carr, D. B., Walker, M., Cobb, J. E., Clissmann, C., O'Gorman, D. J., Nolan, J. J. & DEXLIFE Consortium, Nov 2014, In : Diabetes Research and Clinical Practice. 106, 2, p. 383-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge

    Bondia-Pons, I., Maukonen, J., Mattila, I., Rissanen, A., Saarela, M., Kaprio, J., Hakkarainen, A., Lundbom, J., Lundbom, N., Hyötyläinen, T., Pietiläinen, K. H. & Orešič, M., Sep 2014, In : FASEB Journal. 28, 9, p. 4169-79 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2013
  32. Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry

    Hartonen, M., Mattila, I., Ruskeepää, A-L., Orešič, M. & Hyötyläinen, T., 7 Jun 2013, In : Journal of chromatography. A. 1293, p. 142-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches

    Aura, A-M., Mattila, I., Hyötyläinen, T., Gopalacharyulu, P., Cheynier, V., Souquet, J-M., Bes, M., Le Bourvellec, C., Guyot, S. & Orešič, M., Mar 2013, In : European Journal of Nutrition. 52, 2, p. 833-46 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2012
  35. Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance

    Hyötyläinen, T., Mattila, I., Wiedmer, S. K., Koivuniemi, A., Taskinen, M-R., Yki-Järvinen, H. & Orešič, M., Oct 2012, In : Molecular BioSystems. 8, 10, p. 2559-65 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. 2011
  37. Metabolome in progression to Alzheimer's disease

    Orešič, M., Hyötyläinen, T., Herukka, S-K., Sysi-Aho, M., Mattila, I., Seppänan-Laakso, T., Julkunen, V., Gopalacharyulu, P. V., Hallikainen, M., Koikkalainen, J., Kivipelto, M., Helisalmi, S., Lötjönen, J. & Soininen, H., 13 Dec 2011, In : Translational psychiatry. 1, p. e57

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread

    Bondia-Pons, I., Nordlund, E., Mattila, I., Katina, K., Aura, A-M., Kolehmainen, M., Orešič, M., Mykkänen, H. & Poutanen, K., 19 Oct 2011, In : Nutrition Journal. 10, p. 116

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Metabolic regulation in progression to autoimmune diabetes

    Sysi-Aho, M., Ermolov, A., Gopalacharyulu, P. V., Tripathi, A., Seppänen-Laakso, T., Maukonen, J., Mattila, I., Ruohonen, S. T., Vähätalo, L., Yetukuri, L., Härkönen, T., Lindfors, E., Nikkilä, J., Ilonen, J., Simell, O., Saarela, M., Knip, M., Kaski, S., Savontaus, E. & Orešič, M., Oct 2011, In : PLOS Computational Biology. 7, 10, p. e1002257

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

    Castillo, S., Mattila, I., Miettinen, J., Orešič, M. & Hyötyläinen, T., 15 Apr 2011, In : Analytical Chemistry. 83, 8, p. 3058-67 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Metabolome in schizophrenia and other psychotic disorders: a general population-based study

    Orešič, M., Tang, J., Seppänen-Laakso, T., Mattila, I., Saarni, S. E., Saarni, S. I., Lönnqvist, J., Sysi-Aho, M., Hyötyläinen, T., Perälä, J. & Suvisaari, J., 23 Mar 2011, In : Genome Medicine. 3, 3, p. 19

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro

    Aura, A-M., Mattila, I., Hyötyläinen, T., Gopalacharyulu, P., Bounsaythip, C., Orešič, M. & Oksman-Caldentey, K-M., Feb 2011, In : Molecular BioSystems. 7, 2, p. 437-46 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 51472496