Personal profile
Expertises
Spondyloarthritis.
Main research areas
Dose adjustment of biological treatment in patients with spondyloarthritis (SpA).
Current research
Dose adjustment of biological treatment in SpA patients
Aim: To treat patients with spondyloarthritis (SpA) with the lowest possible effective dose of biological therapy and to determine the overall proportion of patients that can have their biological therapy reduced.
In this open label longitudinal quality control study, patients with SpA in remission will have their dose of biological treatment reduced according to a predefined treatment algorithm and have their dose increased in case of flare. Patient flare is assessed with patient-reported outcome, clinical and imaging measures. In addition blood samples will be collected to assess the predictive value of flare in patients with SpA.
Perspectives
Improved assessment and prediction of disease activity and flare.
Potential conflicts of interest
No current conflicts of interest.
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Collaborations and top research areas from the last five years
Research output
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Construct validity and responsiveness of ASAS Health Index assessed in two longitudinal studies of tumour necrosis factor alpha inhibitor initiation and dose reduction in patients with axial spondyloarthritis
Lorincz, M. P., Østergaard, M., Wetterslev, M., Sørensen, I. J., Madsen, O. R., Christiansen, S. N., Hetland, M. L., Bakkegaard, M., Klarlund, M., Duer, A., Boesen, M., Gosvig, K. K. & Pedersen, S. J., 20 Dec 2024, In: RMD Open. 10, 4, e004948.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of online training on the reliability of assessing sacroiliac joint radiographs in axial spondyloarthritis - a randomized, controlled study
Hadsbjerg, A. E. F., Østergaard, M., Paschke, J., Micheroli, R., Pedersen, S. J., Ciurea, A., Nissen, M. J., Bubova, K., Wichuk, S., De Hooge, M., Krabbe, S., Mathew, A. J., Gregová, M., Wetterslev, M., Gorican, K., Pintaric, K., Snoj, Z., Möller, B., Bernatschek, A. & Donzallaz, M. & 2 others, , 1 Dec 2024, In: Journal of Rheumatology. 51, 12, p. 1169-1175 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus) -
Hip and pelvis region MRI reference image atlas for scoring inflammation in peripheral joints and entheses according to the OMERACT-MRI WIPE scoring system in patients with spondyloarthritis
Østergaard, M., Lambert, R. G., Hadsbjerg, A. E., Eshed, I., Maksymowych, W. P., Mathew, A. J., Jans, L., Pedersen, S. J., Carron, P., Emad, Y., De Marco, G., Bird, P., Stoenoiu, M. S., Foltz, V., Paschke, J., Marzo-Ortega, H., Møller-Bisgaard, S., Conaghan, P. G. & Wetterslev, M., Apr 2024, In: Seminars in Arthritis and Rheumatism. 65, 152383.Research output: Contribution to journal › Journal article › Research › peer-review
2 Citations (Scopus) -
Occurrence and Prediction of Flare After Tapering of Tumor Necrosis Factor Inhibitors in Patients With Axial Spondyloarthritis
Wetterslev, M., Georgiadis, S., Christiansen, S. N., Pedersen, S. J., Sørensen, I. J., Hetland, M. L., Duer, A., Boesen, M., Gosvig, K. K., Møllenbach Møller, J., Bakkegaard, M., Brahe, C. H., Krogh, N. S., Jensen, B., Madsen, O. R., Christensen, J., Hansen, A., Nørregaard, J., Røgind, H. & Østergaard, M., Jan 2024, In: Journal of Rheumatology. 51, 1, p. 39-49 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
4 Citations (Scopus) -
The OMERACT whole-body MRI scoring system for inflammation in peripheral joints and entheses (WIPE) in spondyloarthritis - reference image atlas for the knee region
Østergaard, M., Wetterslev, M., Hadsbjerg, A. E., Maksymowych, W. P., Eshed, I., Jans, L., Emad, Y., Pedersen, S. J., Stoenoiu, M. S., Bird, P., Foltz, V., Mathew, A. J., Paschke, J., Carron, P., De Marco, G., Marzo-Ortega, H., Møller-Bisgaard, S., Conaghan, P. G. & Lambert, R. G., Apr 2024, In: Seminars in Arthritis and Rheumatism. 65, 152384.Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus)