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The Capital Region of Denmark - a part of Copenhagen University Hospital
  1. 2019
  2. Published

    Collagen density regulates the activity of tumor-infiltrating T cells

    Kuczek, D. E., Larsen, A. M. H., Thorseth, M-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12 Mar 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, p. 68

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets

    Jürgensen, H. J., Silva, L. M., Kriegslund, O., Van Putten, S., Madsen, D. H., Behrendt, N., Engelholm, L. H. & Bugge, T. H., Feb 2019, In : Matrix Biology Plus. 100003.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins

    Jürgensen, H. J., Nørregaard, K. S., Sibree, M. M., Santoni-Rugiu, E., Madsen, D. H., Wassilew, K., Krustrup, D., Garred, P., Bugge, T. H., Engelholm, L. H. & Behrendt, N., 7 Jan 2019, In : Journal of Cell Biology. 218, 1, p. 333-349 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2018
  6. Published

    uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis

    Durré, T., Morfoisse, F., Erpicum, C., Ebroin, M., Blacher, S., García-Caballero, M., Deroanne, C., Louis, T., Balsat, C., Van de Velde, M., Kaijalainen, S., Kridelka, F., Engelholm, L., Struman, I., Alitalo, K., Behrendt, N., Paupert, J. & Noel, A., 5 Dec 2018, In : Nature Communications. 9, 1, p. 5178

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2017
  8. Published

    CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma

    Engelholm, L. H., Riaz, A., Serra, D., Dagnæs-Hansen, F., Johansen, J. V., Santoni-Rugiu, E., Hansen, S. H., Niola, F. & Frödin, M., Dec 2017, In : Gastroenterology. 153, 6, p. 1662-1673.e10

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published
  10. Published

    Phagocytosis of Collagen Fibrils by Fibroblasts In Vivo is Independent of the uPARAP/Endo180 Receptor

    Sprangers, S., Behrendt, N., Engelholm, L., Cao, Y. & Everts, V., 2017, In : Journal of Cellular Biochemistry. 118, 6, p. 1590-1595

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion

    Frank, S. R., Köllmann, C. P., van Lidth de Jeude, J. F., Thiagarajah, J. R., Engelholm, L. H., Frödin, M. & Hansen, S. H., 2017, In : Oncogene. 36, 13, p. 1816-1828

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2016
  13. Published

    Crystal structures of the ligand binding region of uPARAP: effect of calcium ion binding

    Yuan, C., Jürgensen, H. J., Engelholm, L. H., Li, R., Liu, M., Jiang, L., Luo, Z., Behrendt, N. & Huang, M., 28 Jul 2016, In : Biochemical Journal. 473, 15, p. 2359-2368

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published
  15. Published

    Early reversal cells in adult human bone remodeling: osteoblastic nature, catabolic functions and interactions with osteoclasts

    Abdelgawad, M. E., Delaisse, J-M., Hinge, M., Jensen, P. R., Alnaimi, R. W., Rolighed, L., Engelholm, L. H., Marcussen, N. & Andersen, T. L., 9 Feb 2016, In : Histochemistry and Cell Biology. 145, 6, p. 603-15

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes

    Kriegbaum, M. C., Jacobsen, B., Füchtbauer, A. C., Hansen, G. H., Christensen, I. J., Rundsten, C. F., Persson, M., Engelholm, L. H., Madsen, A. N., Di Meo, I., Lund, I. K., Holst, B., Kjaer, A., Kjær, A., Lærum, O. D., Füchtbauer, E-M. & Ploug, M., 2016, In : Scientific Reports. 6, p. 25833

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. 2015
  19. Published

    Inflammation and uPAR-Expression in Colorectal Liver Metastases in Relation to Growth Pattern and Neo-adjuvant Therapy

    Eefsen, R. L., Engelholm, L., Alpizar-Alpizar, W., Van den Eynden, G. G. E., Vermeulen, P. B., Christensen, I. J., Laerum, O. D., Rolff, H. C., Høyer-Hansen, G., Vainer, B., Osterlind, K. & Illemann, M., 14 Aug 2015, In : Cancer Microenvironment. 8, 2, p. 93-100

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

    Carlsen Melander, E. M., Jürgensen, H. J., Madsen, D. H., Engelholm, L. H. & Behrendt, N., 12 Aug 2015, In : International Journal of Oncology. 47, 4, p. 1177-88

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published
  22. 2014
  23. Published

    Advances in targeted delivery of small interfering RNA using simple bioconjugates

    Nielsen, C., Kjems, J., Sørensen, K. R., Engelholm, L. H. & Behrendt, N., May 2014, In : Expert Opinion on Drug Delivery. 11, 5, p. 791-822 32 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Complex Determinants in Specific Members of the Mannose Receptor Family Govern Collagen Endocytosis

    Jürgensen, H. J., Johansson, K. B. C., Madsen, D. H., Porse, A., Carlsen Melander, E. M., Nielsen, C., Sørensen, K. R., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 14 Mar 2014, In : The journal of biological chemistry. p. 7935-7947

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    A supra-cellular model for coupling of bone resorption to formation during remodeling: Lessons from two bone resorption inhibitors affecting bone formation differently

    Jensen, P. R., Levin Andersen, T., Pennypacker, B. L., Duong, L. T., Engelholm, L. H. & Delaissé, J-M., 2014, In : Biochemical and Biophysical Research Communications. 443, 2, p. 694-99

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2013
  27. Published

    Loss of miR-10a Activates Lpo and Collaborates with Activated Wnt Signaling in Inducing Intestinal Neoplasia in Female Mice

    Stadthagen, G., Tehler, D. E., Høyland-Kroghsbo, N. M., Wen, J., Krogh, A. S., Jensen, K. T., Santoni-Rugiu, E., Engelholm, L. H. & Lund, A. H., Oct 2013, In : P L o S Genetics (Online). 9, 10, p. e1003913

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway

    Madsen, D. H., Leonard, D., Masedunskas, A., Moyer, A., Jürgensen, H. J., Peters, D. E., Amornphimoltham, P., Selvaraj, A., Yamada, S. S., Brenner, D. A., Burgdorf, S., Engelholm, L. H., Behrendt, N., Holmbeck, K., Weigert, R. & Bugge, T. H., 16 Sep 2013, In : Journal of Cell Biology. 202, 6, p. 951-66 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published
  30. Published

    Tumor MMP-1 Activates Endothelial PAR1 to Facilitate Vascular Intravasation and Metastatic Dissemination

    Juncker-Jensen, A., Deryugina, E. I., Rimann, I., Zajac, E., Kupriyanova, T. A., Engelholm, L. H. & Quigley, J., 16 May 2013, In : Cancer Research. 73, 14, p. 4196-211

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP. Impact on lymphangiogenesis

    Ingvarsen, S., Porse, A., Erpicum, C., Maertens, L., Jürgensen, H. J., Madsen, D. H., Carlsen Melander, E. M., Gårdsvoll, H., Høyer-Hansen, G., Noel, A., Holmbeck, K., Engelholm, L. H. & Behrendt, N., 12 Apr 2013, In : Journal of Biological Chemistry. 288, 15, p. 10195-204

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Differences of macrophage and T cell infiltration in colorectal liver metastases

    Eefsen, R. L., Alpizar, W. E. A., Høyer-Hansen, G., Christensen, I. J., Engelholm, L. H., Lærum, O. D., Vainer, B. & Illemann, M., 2013, In : APMIS Supplementum. 121, S 135, p. 16

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  33. Published

    Differential Actions of the Endocytic Collagen Receptor uPARAP/Endo180 and the Collagenase MMP-2 in Bone Homeostasis

    Madsen, D. H., Jürgensen, H. J., Ingvarsen, S., Carlsen Melander, E. M., Albrechtsen, R., Hald, A., Holmbeck, K., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 2013, In : P L o S One. 8, 8, p. e71261

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Gender affects skin wound healing in plasminogen deficient mice

    Rønø, B., Engelholm, L. H., Lund, L. R. & Hald, A., 2013, In : P L o S One. 8, 3, p. e59942

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2012
  36. Published

    Endocytic collagen degradation: A novel mechanism involved in the protection against liver fibrosis

    Madsen, D. H., Jürgensen, H. J., Ingvarsen, S., Carlsen Melander, E. M., Vainer, B., Egerod, K. L., Hald, A., Rønø, B., Madsen, M. C., Bugge, T. H., Engelholm, L. H. & Behrendt, N., May 2012, In : Journal of Pathology. 227, 1, p. 94-105

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published
  38. Published

    No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer

    Cramer, E. P., Glenthøj, A., Häger, M., Juncker-Jensen, A., Engelholm, L. H., Santoni-Rugiu, E., Lund, L. R., Laerum, O. D., Cowland, J. B. & Borregaard, N., 2012, In : P L o S One. 7, 6, p. e39646

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Plasmin-driven fibrinolysis facilitates skin tumor growth in a gender-dependent manner

    Hald, A., Eickhardt, H. T., Maerkedahl, R. B., Feldborg, C. W., Egerod, K. L., Engelholm, L. H., Laerum, O. D., Lund, L. R. & Rønø, B., 2012, In : F A S E B Journal. 26, 11, p. 4445-57 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2011
  41. Published
  42. Published
  43. Published

    The non-phagocytic route of collagen uptake: a distinct degradation pathway

    Madsen, D. H., Ingvarsen, S., Jürgensen, H. J., Melander, M. C., Kjøller, L., Moyer, A., Honoré, C., Madsen, M. C., Garred, P., Burgdorf, S., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 2011, In : Journal of Biological Chemistry. 286, 30, p. 26996-7010 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. 2010
  45. Published

    Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation

    Sugiyama, N., Varjosalo, M., Meller, P., Lohi, J., Hyytiäinen, M., Kilpinen, S., Kallioniemi, O., Ingvarsen, S., Engelholm, L. H., Taipale, J., Alitalo, K., Keski-Oja, J. & Lehti, K., 15 Oct 2010, In : Cancer Research. 70, 20, p. 7851-61 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2009
  47. Published

    MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny

    Szabova, L., Yamada, S. S., Wimer, H., Chrysovergis, K., Ingvarsen, S., Behrendt, N., Engelholm, L. H. & Holmbeck, K., Nov 2009, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 24, 11, p. 1905-16 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    The collagen receptor uPARAP/Endo180

    Engelholm, L. H., Ingvarsen, S., Jürgensen, H. J., Hillig, T., Madsen, D. H., Nielsen, B. S. & Behrendt, N., 2009, In : Frontiers in Bioscience. 14, p. 2103-14 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2008
  50. Published
  51. Published
  52. Published

    The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue remodeling

    Hillig, T., Engelholm, L. H. & Behrendt, N., 2008, The Cancer Degradome: Proteases and Cancer Biology. Springer Science+Business Media B.V., p. 245-258

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

  53. 2007
  54. Published

    Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation

    Madsen, D. H., Engelholm, L. H., Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, H., Høyer-Hansen, G., Holmbeck, K., Bugge, T. H. & Behrendt, N., 14 Sep 2007, In : The journal of biological chemistry. 282, 37, p. 27037-45 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Complementary roles of intracellular and pericellular collagen degradation pathways in vivo

    Wagenaar-Miller, R. A., Engelholm, L. H., Gavard, J., Yamada, S. S., Gutkind, J. S., Behrendt, N., Bugge, T. H. & Holmbeck, K., Sep 2007, In : Molecular and Cellular Biology. 27, 18, p. 6309-22 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer

    Sulek, J., Wagenaar-Miller, R. A., Shireman, J., Molinolo, A., Madsen, D. H., Engelholm, L. H., Behrendt, N. & Bugge, T. H., Apr 2007, In : The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 55, 4, p. 347-53 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2005
  58. Published

    Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

    Curino, A. C., Engelholm, L. H., Yamada, S. S., Holmbeck, K., Lund, L. R., Molinolo, A. A., Behrendt, N., Nielsen, B. S. & Bugge, T. H., 20 Jun 2005, In : Journal of Cell Biology. 169, 6, p. 977-85 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 2004
  60. Published

    uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV

    Kjøller, L., Engelholm, L. H., Høyer-Hansen, M., Danø, K., Bugge, T. H. & Behrendt, N., 1 Feb 2004, In : Experimental Cell Research. 293, 1, p. 106-16 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. 2003
  62. Published

    uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion

    Engelholm, L. H., List, K., Netzel-Arnett, S., Cukierman, E., Mitola, D. J., Aaronson, H., Kjøller, L., Larsen, J. K., Yamada, K. M., Strickland, D. K., Holmbeck, K., Danø, K., Birkedal-Hansen, H., Behrendt, N. & Bugge, T. H., 31 Mar 2003, In : Journal of Cell Biology. 160, 7, p. 1009-15 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. 2002
  64. Published

    Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

    List, K., Haudenschild, C. C., Szabo, R., Chen, W., Wahl, S. M., Swaim, W., Engelholm, L. H., Behrendt, N. & Bugge, T. H., 23 May 2002, In : Oncogene. 21, 23, p. 3765-79 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells

    Schnack Nielsen, B., Rank, F., Engelholm, L. H., Holm, A., Danø, K. & Behrendt, N., 10 Apr 2002, In : International Journal of Cancer. 98, 5, p. 656-64 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. 2001
  67. Published

    The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis

    Engelholm, L. H., Nielsen, B. S., Netzel-Arnett, S., Solberg, H., Chen, X. D., Lopez Garcia, J. M., Lopez-Otin, C., Young, M. F., Birkedal-Hansen, H., Danø, K., Lund, L. R., Behrendt, N. & Bugge, T. H., Oct 2001, In : Laboratory investigation; a journal of technical methods and pathology. 81, 10, p. 1403-14 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published
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