Kristoffer Staal Rohrberg

2024

CEA-CD3 bispecific antibody cibisatamab with or without atezolizumab in patients with CEA-positive solid tumours: results of two multi-institutional Phase 1 trials

Segal, N. H., Melero, I., Moreno, V., Steeghs, N., Marabelle, A., Rohrberg, K., Rodriguez-Ruiz, M. E., Eder, J. P., Eng, C., Manji, G. A., Waterkamp, D., Leutgeb, B., Bouseida, S., Flinn, N., Das Thakur, M., Elze, M. C., Koeppen, H., Jamois, C., Martin-Facklam, M. & Lieu, C. H. & 4 others, Calvo, E., Paz-Ares, L., Tabernero, J. & Argilés, G., 15 May 2024, In: Nature Communications. 15, 1, p. 4091 4091.

Research output: Contribution to journal › Journal article › Research › peer-review

Comprehensive analysis of failure to carry out successful genomic profiling in a phase I setting

Belcaid, L., Iden, C., Jacobsen, I., Højgaard, M., Spanggaard, I., Tuxen, I. V., Mau-Sørensen, M., Lassen, U., Yde, C. W. & Rohrberg, K. S., 3 Jun 2024, In: ESMO Open. 9, 6, 103495.

Research output: Contribution to journal › Letter › peer-review

Cytokinfrigivelsessyndrom ved behandling af kræftsygdom med CAR-T og T-celleengagere

Translated title of the contribution: Cytokine release syndrome caused by antineoplastic treatment with CAR-T and T-cell engaging therapiesAgner, B. R., Riley, C. H., Petersen, S. L., Spanggaard, I., Hutchings, M., Rohrberg, K. S. & Højgaard, M., 26 Feb 2024, In: Ugeskrift for Laeger. 186, 9, V08230544.

Research output: Contribution to journal › Review › peer-review

High-throughput molecular assays for inclusion in personalised oncology trials - State-of-the-art and beyond

Edsjö, A., Russnes, H. G., Lehtiö, J., Tamborero, D., Hovig, E., Stenzinger, A., Rosenquist, R., PCM4EU consortium, Rohrberg, K. S. (Member of study group) & Lassen, U. (Member of study group), 2024, In: Journal of Internal Medicine. 295, 6, p. 785-803 19 p.

Research output: Contribution to journal › Review › peer-review

3 Citations (Scopus)

Improve: a feature model to predict neoepitope immunogenicity through broad-scale validation of T-cell recognition

Borch, A., Carri, I., Reynisson, B., Alvarez, H. M. G., Munk, K. K., Montemurro, A., Kristensen, N. P., Tvingsholm, S. A., Holm, J. S., Heeke, C., Moss, K. H., Hansen, U. K., Schaap-Johansen, A.-L., Bagger, F. O., de Lima, V. A. B., Rohrberg, K. S., Funt, S. A., Donia, M., Svane, I. M. & Lassen, U. & 3 others, Barra, C., Nielsen, M. & Hadrup, S. R., 2024, In: Frontiers in Immunology. 15, 1360281.

Research output: Contribution to journal › Journal article › Research › peer-review

Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors

Peters, S., Angevin, E., Alonso-Gordoa, T., Rohrberg, K., Melero, I., Mellado, B., Perez-Gracia, J. L., Tabernero, J., Adessi, C., Boetsch, C., Watson, C., Dal Porto, J., Dejardin, D., DelNagro, C., Nicolini, V., Evers, S., Klein, C., Leutgeb, B., Pisa, P. & Rossmann, E. & 5 others, Saro, J., Umana, P., Charo, J., Teichgräber, V. & Steeghs, N., 15 Apr 2024, In: Clinical Cancer Research. 30, 8, p. 1630-1641 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

PCM4EU and PRIME-ROSE: Collaboration for implementation of precision cancer medicine in Europe

Taskén, K., F Haj Mohammad, S., Fagereng, G. L., Sørum Falk, R., Helland, Å., Barjesteh van Waalwijk van Doorn-Khosrovani, S., Steen Carlsson, K., Ryll, B., Jalkanen, K., Edsjö, A., Russnes, H. G., Lassen, U., Hallersjö Hult, E., Lugowska, I., Blay, J.-Y., Verlingue, L., Abel, E., Lowery, M. A., Krebs, M. G. & Staal Rohrberg, K. & 6 others, Ojamaa, K., Oliveira, J., Verheul, H. M. W., Voest, E. E., Gelderblom, H. & PRIME-ROSE Consortium and the PCM4EU Consortium, 23 May 2024, In: Acta Oncologica. 63, p. 385-391 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity from a Phase I Study of Simlukafusp Alfa (FAP-IL2v) in Advanced/Metastatic Solid Tumors

Steeghs, N., Gomez-Roca, C., Rohrberg, K. S., Mau-Sørensen, M., Robbrecht, D., Tabernero, J., Ahmed, S., Rodriguez-Ruiz, M. E., Ardeshir, C., Schmid, D., Sleiman, N., Watson, C., Piper-Lepoutre, H., Dejardin, D., Evers, S., Boetsch, C., Charo, J., Teichgräber, V. & Melero, I., 1 Jul 2024, In: Clinical Cancer Research. 30, 13, p. 2693-2701 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Similar genetic profile in early and late stage urothelial tract cancer

Stormoen, D. R., Rohrberg, K. S., Mouw, K. W., Ørum, K., Szallasi, Z., Rossing, M., Bagger, F. O. & Pappot, H., 8 Jul 2024, In: Journal of Cancer Research and Clinical Oncology. 150, 7, p. 339 339.

Research output: Contribution to journal › Journal article › Research › peer-review

2023

A first-in-human study of the fibroblast activation protein-targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors

Melero, I., Tanos, T., Bustamante, M., Sanmamed, M. F., Calvo, E., Moreno, I., Moreno, V., Hernandez, T., Martinez Garcia, M., Rodriguez-Vida, A., Tabernero, J., Azaro, A., Ponz-Sarvisé, M., Spanggaard, I., Rohrberg, K., Guarin, E., Nüesch, E., Davydov, I. I., Ooi, C. & Duarte, J. & 5 others, Chesne, E., McIntyre, C., Ceppi, M., Cañamero, M. & Krieter, O., 10 May 2023, In: Science translational medicine. 15, 695, abp9229.

Research output: Contribution to journal › Journal article › Research › peer-review

Avelumab Plus Talazoparib in Patients With Advanced Solid Tumors: The JAVELIN PARP Medley Nonrandomized Controlled Trial

Yap, T. A., Bardia, A., Dvorkin, M., Galsky, M. D., Beck, J. T., Wise, D. R., Karyakin, O., Rubovszky, G., Kislov, N., Rohrberg, K., Joy, A. A., Telli, M. L., Schram, A. M., Conte, U., Chappey, C., Stewart, R., Stypinski, D., Michelon, E., Cesari, R. & Konstantinopoulos, P. A., 1 Jan 2023, In: JAMA Oncology. 9, 1, p. 40-50 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Clinical implication of genetic intratumor heterogeneity for targeted therapy in head and neck cancer

Gram, S. B., Alosi, D., Bagger, F. O., Østrup, O., von Buchwald, C., Friborg, J., Wessel, I., Vogelius, I. R., Rohrberg, K. & Rasmussen, J. H., Dec 2023, In: Acta Oncologica. 62, 12, p. 1831-1839 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

New pathogenic germline variants identified in mesothelioma

Belcaid, L., Bertelsen, B., Wadt, K., Tuxen, I., Spanggaard, I., Højgaard, M., Benn Sørensen, J., Ravn, J., Lassen, U., Cilius Nielsen, F., Rohrberg, K. & Westmose Yde, C., 2023, In: Lung Cancer. 179, p. 1-8 8 p., 107172.

Research output: Contribution to journal › Review › peer-review

ProTarget: a Danish Nationwide Clinical Trial on Targeted Cancer Treatment based on genomic profiling - a national, phase 2, prospective, multi-drug, non-randomized, open-label basket trial

Kringelbach, T., Højgaard, M., Rohrberg, K., Spanggaard, I., Laursen, B. E., Ladekarl, M., Haslund, C. A., Harsløf, L., Belcaid, L., Gehl, J., Søndergaard, L., Eefsen, R. L., Hansen, K. H., Kodahl, A. R., Jensen, L. H., Holt, M. I., Oellegaard, T. H., Yde, C. W., Ahlborn, L. B. & Lassen, U., 22 Feb 2023, In: BMC Cancer. 23, 1, 182.

Research output: Contribution to journal › Journal article › Research › peer-review

Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade

Nazerai, L., Willis, S. C., Yankilevich, P., Di Leo, L., Bosisio, F. M., Frias, A., Bertolotto, C., Nersting, J., Thastrup, M., Buus, S., Thomsen, A. R., Nielsen, M., Rohrberg, K. S., Schmiegelow, K. & De Zio, D., 2023, In: OncoImmunology. 12, 1, 2158610.

Research output: Contribution to journal › Journal article › Research › peer-review

2022

A phase II study of daily encorafenib in combination with biweekly cetuximab in patients with BRAF V600E mutated metastatic colorectal cancer: the NEW BEACON study

Eriksen, M., Pfeiffer, P., Rohrberg, K. S., Yde, C. W., Petersen, L. N., Poulsen, L. Ø. & Qvortrup, C., 16 Dec 2022, In: BMC Cancer. 22, 1, p. 1-6 6 p., 1321.

Research output: Contribution to journal › Journal article › Research › peer-review

Differences in gene expression despite identical histomorphology in sinonasal intestinal type adenocarcinoma and metastases from colorectal adenocarcinoma

Sjöstedt, S., Vieira, F. G., Karnov, K., Agander, T. K., Willemoe, G. L., Rohrberg, K. S., Nielsen, F. C. & von Buchwald, C., Sept 2022, In: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 9, p. 551-559 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Extensive genomic analysis in patients with KRAS-mutated solid tumors shows high frequencies of concurrent alterations and potential targets but has limited clinical impact

Jacobsen, I. C., Spanggaard, I., Højgaard, M., Belcaid, L., Qvortrup, C., Yde, C. W., Schmidt, A. Y., Nielsen, F. C., Willemoe, G. L., Dam, M. S., Lassen, U. & Staal Rohrberg, K., Dec 2022, In: Acta Oncologica. 61, 12, p. 1499-1506 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Modeling Metastatic Colonization in a Decellularized Organ Scaffold-Based Perfusion Bioreactor

Rafaeva, M., Horton, E. R., Jensen, A. R. D., Madsen, C. D., Reuten, R., Willacy, O., Brøchner, C. B., Jensen, T. H., Zornhagen, K. W., Crespo, M., Grønseth, D. S., Nielsen, S. R., Idorn, M., Straten, P. T., Rohrberg, K., Spanggaard, I., Højgaard, M., Lassen, U., Erler, J. T. & Mayorca-Guiliani, A. E., 5 Jan 2022, In: Advanced healthcare materials. 11, 1, 2100684.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Patients in phase 1 cancer trials: psychological distress and understanding of trial information

Gad, K. T., Lassen, U., Duun-Henriksen, A. K., Dalton, S. O., Mau-Sørensen, M., Bidstrup, P. E., Høeg, B. L., Rohrberg, K. S., Spanggaard, I., von Heymann, A. & Johansen, C., 2022, In: Acta Oncologica. 61, 3, p. 341-348 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Personalized circulating tumor DNA in patients with hepatocellular carcinoma: a pilot study

Pommergaard, H. C., Yde, C. W., Ahlborn, L. B., Andersen, C. L., Henriksen, T. V., Hasselby, J. P., Rostved, A. A., Sørensen, C. L., Rohrberg, K. S., Nielsen, F. C. & Rasmussen, A., Feb 2022, In: Molecular Biology Reports. 49, 2, p. 1609-1616 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Precision patients: Selection practices and moral pathfinding in experimental oncology

Dam, M. S., Green, S., Bogicevic, I., Hillersdal, L., Spanggaard, I., Rohrberg, K. S. & Svendsen, M. N., Feb 2022, In: Sociology of health & illness. 44, 2, p. 345-359 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2021

Detecting and Targeting NTRK Fusions in Cancer in the Era of Tumor Agnostic Oncology

Rohrberg, K. S. & Lassen, U., Mar 2021, In: Drugs. 81, 4, p. 445-452 8 p.

Research output: Contribution to journal › Review › peer-review

Immune Cell Profiling of Peripheral Blood as Signature for Response During Checkpoint Inhibition Across Cancer Types

Araujo B de Lima, V., Hansen, M., Spanggaard, I., Rohrberg, K., Reker Hadrup, S., Lassen, U. & Svane, I. M., 25 Mar 2021, In: Frontiers in Oncology. 11, p. 558248 558248.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors

Wick, A., Bähr, O., Schuler, M., Rohrberg, K., Chawla, S. P., Janku, F., Schiff, D., Heinemann, V., Narita, Y., Lenz, H.-J., Ikeda, M., Ando, Y., Wick, W., Steinbach, J. P., Burger, M. C., Wenger, K., Lassen, U., Sankhala, K. K., Roggia, C. & Genvresse, I. & 11 others, Munhoz, C., Rentzsch, C., Reschke, S., Langer, S., Wagner, M., Kaulfuss, S., Cai, C., Lagkadinou, E., Jeffers, M., Peña, C. & Tabatabai, G., 15 May 2021, In: Clinical Cancer Research. 27, 10, p. 2723-2733 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The somatic mode: doing good in targeted cancer therapy.

Rohrberg, K. S., Bogicevic, I., Høgdall, E. V. S. & Svendsen, M. N., Jul 2021, In: New Genetics and Society. 40, 2, p. 178-198 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2020

Common phenotypic dynamics of tumor-infiltrating lymphocytes across different histologies upon checkpoint inhibition: impact on clinical outcome

Araujo B de Lima, V., Borch, A., Hansen, M., Draghi, A., Spanggaard, I., Rohrberg, K., Reker Hadrup, S., Lassen, U. & Svane, I. M., Apr 2020, In: Cytotherapy. 22, 4, p. 204-213 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2019

Application of cell-free DNA for genomic tumor profiling: a feasibility study

Ahlborn, L. B., Rohrberg, K. S., Gabrielaite, M., Tuxen, I. V., Yde, C. W., Spanggaard, I., Santoni-Rugiu, E., Nielsen, F. C., Lassen, U., Mau-Sorensen, M. & Østrup, O., 15 Feb 2019, In: Oncotarget. 10, 14, p. 1388-1398 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Copenhagen Prospective Personalized Oncology (CoPPO) - Clinical utility of using molecular profiling to select patients to phase 1 trials

Tuxen, I. V., Rohrberg, K. S., Østrup, O., Ahlborn, L. B., Schmidt, A. Y., Spanggaard, I., Hasselby, J. P., Santoni-Rugiu, E., Yde, C. W., Mau-Soerensen, M., Nielsen, F. C. & Lassen, U., 2019, In: Clinical Cancer Research. 25, 4, p. 1239-1247 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer

Bertelsen, B., Tuxen, I. V., Yde, C. W., Gabrielaite, M., Torp, M. H., Kinalis, S., Oestrup, O., Rohrberg, K., Spangaard, I., Santoni-Rugiu, E., Wadt, K., Mau-Sorensen, M., Lassen, U. & Nielsen, F. C., 2019, In: Genome Medicine. 4, 1, p. 13 13.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Nivolumab Alone and With Ipilimumab in Previously Treated Metastatic Urothelial Carcinoma: CheckMate 032 Nivolumab 1 mg/kg Plus Ipilimumab 3 mg/kg Expansion Cohort Results

Sharma, P., Siefker-Radtke, A., de Braud, F., Basso, U., Calvo, E., Bono, P., Morse, M. A., Ascierto, P. A., Lopez-Martin, J., Brossart, P., Rohrberg, K., Mellado, B., Fischer, B. S., Meadows-Shropshire, S., Abdel Saci, Callahan, M. K. & Rosenberg, J., 1 Jul 2019, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 19, p. 1608-1616 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

192 Citations (Scopus)

Plasma total cell-free DNA is a prognostic biomarker of overall survival in metastatic solid tumour patients

Viller Tuxen, I., Barlebo Ahlborn, L., Mau-Soerensen, M., Staal Rohrberg, K., Cilius Nielsen, F., Oestrup, O., Westmose Yde, C., Richter Vogelius, I. & Lassen, U., Jul 2019, In: British Journal of Cancer. 121, 2, p. 125-130 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Trends in oncological phase I trials

Rohrberg, K. S., Qvortrup, C., Højgaard, M. & Spanggaard, I., 14 Oct 2019, In: Ugeskrift for Laeger. 181, 20A

Research output: Contribution to journal › Journal article › Research › peer-review

2018

Circulating tumor DNA as a marker of treatment response in BRAF V600E mutated non-melanoma solid tumors

Ahlborn, L. B., Tuxen, I. V., Mouliere, F., Kinalis, S., Schmidt, A. Y., Rohrberg, K. S., Santoni-Rugiu, E., Nielsen, F. C., Lassen, U., Yde, C. W., Oestrup, O. & Mau-Sorensen, M., 24 Aug 2018, In: Oncotarget. 9, 66, p. 32570-32579 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

2012

Phase II trial of erlotinib and bevacizumab in patients with advanced upper gastrointestinal cancers

Rohrberg, K. S., Olesen, R. K., Pfeiffer, P., Ladekarl, M., Pappot, H., Christensen, I. J., Høyer-Hansen, G., Sørensen, M., Skov, B. G., Buysschaert, I., Carmeliet, P. & Lassen, U., 2012, In: Acta Oncologica. 51, 2, p. 234-42 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

2011

A Phase I-II dose escalation study of fixed-dose rate gemcitabine, oxaliplatin and capecitabine every two weeks in advanced cholangiocarcinomas

Lassen, U., Jensen, L. H., Mau-Sørensen, P. M., Rohrberg, K. S., Ujmajuridze, Z. & Jakobsen, A., 1 Apr 2011, In: Acta oncologica . 50, 3, p. 448-54 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Biomarkers in tissue from patients with upper gastrointestinal cancers treated with erlotinib and bevacizumab

Rohrberg, K. S., Pappot, H., Lassen, U., Westman, M., Olesen, R. K., Pfeiffer, P., Ladekarl, M., Mau-Sørensen, P. M., Christensen, I. J. & Skov, B. G., Apr 2011, In: Cancer Biology & Therapy. 11, 8, p. 732-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

2010

Markers of angiogenesis and epidermal growth factor receptor signalling in patients with pancreatic and gastroesophageal junction cancer

Rohrberg, K. S., Skov, B. G., Lassen, U., Christensen, I. J., Høyer-Hansen, G., Buysschaert, I. & Pappot, H., 1 Jan 2010, In: Cancer biomarkers : section A of Disease markers. 7, 3, p. 141-51 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Kristoffer Staal Rohrberg

Research output

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