Research output per year
Research output per year
Personal profile
Expertises
- Acute myeloid leukemia. (AML).
- Hematology
Main research areas
- Mapping of clonal hierarchies in patients with acute myeloid leukemia (AML).
- Identification and therapeutic targeting of oncogenic signaling pathways in AML.
- Application of "omics" technologies to improve prediction of therapy response in patients with AML.
Current research
The major focus of the laboratory´s translational research program is to compare cancer cells to their closest normal cellular counterpart using a variety of “omics” technologies in order to improve prognostication as well as identify novel targets such as for treatment of patients with acute myeloid leukemia (AML).
Potential conflicts of interest
None.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, H., Dufva, O., Vähä-Koskela, M., Leppä, A-M., Huuhtanen, J., Vänttinen, I. M., Nygren, P. J., Klievink, J., Bouhlal, J. O. V., Pölönen, P., Zhang, Q., Adnan Awad, S., Mancebo-Pérez, C., Saad, J., Miettinen, J. J., Javarappa, K. K., Aakko, S., Ruokoranta, T., Eldfors, S., Heinäniemi, M., & 9 others, 30 Mar 2023, In: Blood. 141, 13, p. 1610-1625 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus) -
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes
Trempenau, M. L., Schuster, M. B., Pundhir, S., Pereira, M. A., Kalvisa, A., Tapia, M., Su, J., Ge, Y., de Boer, B., Balhuizen, A., Bagger, F. O., Shliaha, P., Sroczynska, P., Walfridsson, J., Grønbæk, K., Theilgaard-Mönch, K., Jensen, O. N., Helin, K. & Porse, B. T., Mar 2023, In: Leukemia. 37, 3, p. 593-605 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Trends in survival and cure after allogeneic haematopoietic cell transplantation for acute myeloid leukaemia from 2000 to 2020: A Danish population-based cohort study
Gjaerde, L. K., Jakobsen, L. H., Juhl-Christensen, C., Olesen, G., Petruskevicius, I., Severinsen, M. T., Marcher, C. W., Theilgaard-Mönch, K., Andersen, N. S., Friis, L. S., Kornblit, B., Petersen, S. L., Schjødt, I. & Sengeløv, H., Feb 2023, In: British Journal of Haematology. 200, 4, p. e40-e43Research output: Contribution to journal › Comment/debate › Research › peer-review
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Effects of chemotherapy dose reductions in overweight patients with acute myeloid leukaemia: A Danish nationwide cohort study
Kristensen, D. T., Nielsen, L. B., Jakobsen, L. H. K., Kristensen, T-C. C., Jepsen, L. Ø., Schöllkopf, C., Theilgaard-Mönch, K., El-Galaly, T. C., Roug, A. S. & Severinsen, M. T., Nov 2022, In: British Journal of Haematology. 199, 4, p. 539-548 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML
Centio, A., Estruch, M., Reckzeh, K., Sanjiv, K., Vittori, C., Engelhard, S., Warpman Berglund, U., Helleday, T. & Theilgaard-Mönch, K., 4 May 2022, In: Molecular Cancer Therapeutics. 21, 5, p. 703-714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review