Research output per year
Research output per year
Personal profile
Expertises
I'm a MD doing clinical and experimental research primarily within the field of non alcoholic fatty liver disease (NAFLD) and obesity.
Main research areas
NAFLD; NASH; Liver fibrosis; Liver cirrhosis; Obesity; low grade systemic inflammation; metabolism; gut microbiota; Adipose tissue inflammation; transcriptomics
Current research
I investigate the association between gut microbiota composition and severity of biopsyproven NAFLD in 70 severely obese individuals undergoing bariatric surgery at Hvidovre Hospital. Follow-up liver biopsies are performed 1 year postoperatively in those with NASH and/or liver fibrosis. Furthermore I investigate other potential patophysiological drivers for development of the progressive NAFLD subtypes; non alcoholic steatohepatitis (NASH) and NASH fibrosis.
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Collaborations and top research areas from the last five years
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Biomarkers reflecting pericellular fibrosis improve together with liver histology after bariatric surgery in early non-alcoholic fatty liver disease
Lønsmann, I., Steen Pedersen, J., Krag, A., Hansen, T., Karsdal, M., Julie Leeming, D., Juul Nielsen, M. & Bendtsen, F., Mar 2023, In: Clinical Biochemistry. 113, p. 29-35 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration
Pedersen, J. S., Rygg, M. O., Chrøis, K., Sustarsic, E. G., Gerhart-Hines, Z., Wever Albrechtsen, N. J., Serizawa, R. R., Kristiansen, V. B., Basse, A. L., Boilesen, A. E. B., Olsen, B. H., Hansen, T., Gluud, L. L., Madsbad, S., Larsen, S., Bendtsen, F. & Dela, F., 25 May 2022, In: Nature Communications. 13, 1, p. 1-15 15 p., 2931.Research output: Contribution to journal › Journal article › Research › peer-review
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Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitis
Fred, R. G., Steen Pedersen, J., Thompson, J. J., Lee, J., Timshel, P. N., Stender, S., Opseth Rygg, M., Gluud, L. L., Bjerregaard Kristiansen, V., Bendtsen, F., Hansen, T. & Pers, T. H., 5 Aug 2022, In: Scientific Reports. 12, 1, p. 1-13 13 p., 13484.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Non-Alcoholic Fatty Liver Disease: A 12-Month Follow-Up Study with Paired Liver Biopsies
Pedersen, J. S., Rygg, M. O., Serizawa, R. R., Kristiansen, V. B., Albrechtsen, N. J. W., Gluud, L. L., Madsbad, S. & Bendtsen, F., Aug 2021, In: Journal of Clinical Medicine. 10, 17, p. 1-12 12 p., 3783.Research output: Contribution to journal › Journal article › Research › peer-review
19 Citations (Scopus) -
Impact of non-alcoholic fatty liver disease (NAFLD) on metabolism in liver disease and adipose tissue: Focus on mitochondrial function, inflammation and the liver-alpha cells axis
Pedersen, J. S., 8 Oct 2021Research output: Book/Report › Ph.D. thesis