Research output per year
Research output per year
Personal profile
Curriculum
Senior Scientist, Associate Professor
Current position:
-Senior Scientist, Copenhagen Hepatitis C Program (CO-HEP) at Copenhagen University Hospital, Hvidovre
-Associate Professor in Experimental Control of Hepatitis C Virus, Faculty of Health and Medical Sciences at University of Copenhagen
Scientific focus areas:
In vitro studies of hepatitis C virus sensitivity and resistance to antivirals.
Hepatitis C virus vaccine development.
Development of hepatitis C virus cell culture systems.
Education:
2001 Doctoral degree (Dr. med.) at Ruprecht-Karls-University Heidelberg
1994-2001 Studies of Medicine, MD, Ruprecht-Karls-University Heidelberg Fellowship of the German National Academic Foundation
Practical Professional Education:
09/2005 - present Senior scientist, CO-HEP, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark.
11/2004 - 08/2005 Research and Clinical Associate, Department of Internal Medicin, University Hospital Bonn, Germany.
02/2003 - 08/2004 Clinical Associate, Department of Internal Medicine, Spital Limmattal Zurich, Switzerland.
01/2002 - 01/2003 Research Associate, Department of Neuropathology, University Hospital Zurich, Switzerland. .
09/1997- 10/1998 Research fellowship at the Department of Pathology, Case Western Reserve University, Cleveland, USA.
Contact: [email protected]
Expertises
HCV virology; HCV cell culture development; Study of antiviral compounds; HCV vaccine development; Cell culture; Molecular biology; Medicine
Main research areas
Main research areas are studies of resistance of HCV to antivirals and HCV vaccine development with focus on whole virus inactivated and virus like particle vaccine candidates.
Current research
We are characterizing the efficacy of antivirals and combinations of antivirals against different HCV variants. We further study HCV resistance to antivirals including identification of resistance associated substitutions and mechanisms of resistance development.
We investigate development of HCV vaccine candidates. We are establishing a bioprocess for development of whole viral particle inactivated vaccine candidates. We are testing such vaccine candidates and vaccine candidates based on virus like particles.
Potential conflicts of interest
none
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Collaborations and top research areas from the last five years
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An inactivated SARS-CoV-2 vaccine based on a Vero cell culture-adapted high-titer virus confers cross-protection in small animals
Offersgaard, A., Duarte Hernandez, C. R., Zhou, Y., Duan, Z., Gammeltoft, K. A., Hartmann, K. T., Fahnøe, U., Marichal-Gallardo, P., Alzua, G. P., Underwood, A. P., Sølund, C., Weis, N., Bonde, J. H., Christensen, J. P., Pedersen, G. K., Jensen, H. E., Holmbeck, K., Bukh, J. & Gottwein, J. M., 24 Jul 2024, In: Scientific Reports. 14, 1, p. 17039 17039.Research output: Contribution to journal › Journal article › Research › peer-review
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JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in the evaluation of virus neutralization
Collignon, L., Holmbeck, K., Just, A., Verhoye, L., Velázquez-Moctezuma, R., Fahnøe, U., Carlsen, T. H. R., Law, M., Prentoe, J., Scheel, T. K. H., Gottwein, J. M., Meuleman, P. & Bukh, J., 23 Apr 2024, (E-pub ahead of print) In: Hepatology (Baltimore, Md.).Research output: Contribution to journal › Journal article › Research › peer-review
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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Karim, M., Mishra, M., Lo, C.-W., Saul, S., Cagirici, H. B., Tran, D. H. N., Agrawal, A., Ghita, L., Ojha, A., East, M. P., Gammeltoft, K. A., Sahoo, M. K., Johnson, G. L., Das, S., Jochmans, D., Cohen, C. A., Gottwein, J., Dye, J., Neff, N. & Pinsky, B. A. & 7 others, , 17 Apr 2024, In: bioRxiv.Research output: Contribution to journal › Journal article › Research › peer-review
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An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals
Offersgaard, A., Duarte Hernandez, C. R., Feng, S., Marichal-Gallardo, P., Holmbeck, K., Pihl, A. F., Fernandez-Antunez, C., Alzua, G. P., Hartmann, K. T., Pham, L. V., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Schneider, U. V., Pedersen, G. K., Jensen, H. E., Christensen, J. P., Ramirez, S., Bukh, J. & Gottwein, J. M., 17 Feb 2023, In: iScience. 26, 2, p. 105949 105949.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system
Fernandez-Antunez, C., Wang, K., Fahnøe, U., Mikkelsen, L. S., Gottwein, J. M., Bukh, J. & Ramirez, S., Aug 2023, In: Hepatology (Baltimore, Md.). 78, 2, p. 621-636 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
5 Citations (Scopus)